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January 07, 2014; 82 (1) Article

Effect of head impacts on diffusivity measures in a cohort of collegiate contact sport athletes

Thomas W. McAllister, James C. Ford, Laura A. Flashman, Arthur Maerlender, Richard M. Greenwald, Jonathan G. Beckwith, Richard P. Bolander, Tor D. Tosteson, John H. Turco, Rema Raman, Sonia Jain
First published December 11, 2013, DOI: https://doi.org/10.1212/01.wnl.0000438220.16190.42
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Article Information

vol. 82 no. 1 63-69
DOI: 
https://doi.org/10.1212/01.wnl.0000438220.16190.42
PubMed: 
24336143
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 8, 2013
  • Accepted in final form September 18, 2013
  • First Published December 11, 2013.

Article Versions

Copyright & Usage: 
© 2013 American Academy of Neurology

Author Disclosures

    1. Thomas W. McAllister, MD,
    2. James C. Ford, PhD,
    3. Laura A. Flashman, PhD,
    4. Arthur Maerlender, PhD,
    5. Richard M. Greenwald, PhD,
    6. Jonathan G. Beckwith, MS,
    7. Richard P. Bolander, PhD,
    8. Tor D. Tosteson, ScD,
    9. John H. Turco, MD,
    10. Rema Raman, PhD and
    11. Sonia Jain, PhD
  1. Thomas W. McAllister, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH R01HD048638 (2) NIH RO1NS055020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. James C. Ford, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. National Operating Committee on Standards for Athletic Equipment (NOCSAE)

    Research Support, Government Entities:

    1. (1) Department of Defense (subcontract through University of California, San Diego, site PI: McAllister),

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Laura A. Flashman, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Robin Hill Farm, Peterborough, NH (2) Independent Services Network, Inc., Manchester, NH

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH/DIDCD/NINDS R01, Investigator, Neuropsychologist, July 2006 � June 2011; (2) NIH/NIA; Dartmouth Site PI, July 2007 � July 2012; (3) NIH/ NINDS, Investigator, Neuropsychologist, Aug 2007-June 2012; (4) Centers for Disease Control, Investigator, Neuropsychologist, Sept 2007-August 2010; (5) DoD USAMRAA, Investigator, Neuropsychologist, Sept 2008 � Sept 2013

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Arthur Maerlender, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Wechsler Intelligence test for Children, 4th Ed. Integrated, Pearson, 2005 Test, Administration Manual and Technical Manual

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Richard M. Greenwald, PhD,
    6. Scientific Advisory Boards:

    1. (1) National Operating Committee for Standards in Athletic Equipment; (2) National Advisory Council for Child Health and Human Development (NIH)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Simbex, President

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) National Operating Committee for Standards in Athletic Equipment, June 2011 - May 2013; (2) National Institutes of Health, R44HD0868054 FastTrack SBIR, April 2011-December 2013; (3) NIH R24HD065703 - Part of the NCMRR/NICHD rehabilitation infrastructure network, September 2010-May 2015; (4) NIH R44HD061224 � Phase II SBIR � April 2010 � March 2012.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NOCSAE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. (1) Hillerich and Bradsby - Expert witness for defense, 2010, 2011 - paid to Simbex

  6. Jonathan G. Beckwith, MS,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Simbex, Director of Research, 9

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Simbex, Lebanon NH

    Research Support, Government Entities:

    1. (1) NIH R01HD048638, Engineer, 5; (2) NIH RO1NS05502, Engineer, 5; (3) NIH/CDC R01CE001254, Engineer, 4

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Richard P. Bolander, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Simbex LLC, Biomechanics Researcher, 8/15/2011 to Present

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Simbex LLC

    Research Support, Government Entities:

    1. NIH/NIHCD, R01HD048638 Greenwald (PI), Researcher/Analyst, 1.5 Years

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1)National Operating Committee for Sports Athletic Equipment, SAC-01

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Tor D. Tosteson, ScD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Spine Journal, Associate Board,

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH,#RO1NS055020, Co-Investigator, 2007-2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. John H. Turco, MD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Rema Raman, PhD and
    11. Scientific Advisory Boards:

    1. DSMB Member, Lipoic acid and omega-3 fatty acids in Alzheimer�s disease DSMB Member, The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial DSMB Member: Development of NIC5-15 in the Treatment of Alzheimer�s Disease DSMB Member: PROGrESS (PROlonGed ExpoSure Sertraline) Trial

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Funded as the co-investigator by NIH grants # 2P50NS044148 Biostatistician (2008-present), # U01AG010483 Biostatistician (2007-present), # 1R01HD053074-01A1 Biostatistician (2007-present), W81XWH08-2-0159 Biostatistician (2008-2013) and # U01AG024904 Biostatistician (2011-present), and research support from Baxter IgIV Protocol #160701 Biostatistician (2008-present)and Eli Lilly and Company � DAPC LY450139 Biostatistician (2012 - present).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Sonia Jain, PhD
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Psychiatry (T.W.M., J.C.F., L.A.F., A.M.), Community and Family Medicine (T.D.T.), and Medicine (J.H.T.), Geisel School of Medicine at Dartmouth College, Hanover, NH; Simbex, LLC (R.M.G., J.G.B., R.P.B.), Lebanon, NH; Thayer School of Engineering (R.M.G.), Dartmouth College, Hanover, NH; and Biostatistics Research Center (R.R., S.J.), Department of Family and Preventive Medicine, University of California, San Diego.
  1. Correspondence to Dr. McAllister: twmcalli{at}iupui.edu
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