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March 25, 2014; 82 (12) Article

Contribution of Alzheimer disease to mortality in the United States

Bryan D. James, Sue E. Leurgans, Liesi E. Hebert, Paul A. Scherr, Kristine Yaffe, David A. Bennett
First published March 5, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000240
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Article Information

vol. 82 no. 12 1045-1050
DOI: 
https://doi.org/10.1212/WNL.0000000000000240
PubMed: 
24598707
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 12, 2013
  • Accepted in final form December 11, 2013
  • First Published March 5, 2014.

Article Versions

Copyright & Usage: 
© 2014 American Academy of Neurology

Author Disclosures

    1. Bryan D. James, PhD,
    2. Sue E. Leurgans, PhD,
    3. Liesi E. Hebert, ScD,
    4. Paul A. Scherr, PhD, ScD,
    5. Kristine Yaffe, MD and
    6. David A. Bennett, MD
  1. Bryan D. James, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Alzheimer's Association (2) Partners Healthcare

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Sue E. Leurgans, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH: P30AG010161 (ADC), core Leader and statistician, 2007-ongoing (2) NIH: RC2AG036547, statistician (3) NIH: R01 AG017917, statistician, 2008-present (4) NIH: P01 AG014449, Core leader, 2001-present (5) NIH: P01 AG009466, Core Leader, 2000-present (6) NIH: R01NS028127, statistician, 2006-present (7) NIH: R01 AG024480, statistician, 2007-present (8) NIH: R01 AG033678, statistician, 2008-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Liesi E. Hebert, ScD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH R01NR010211 PI 2009-2012 NIH R01AG030544 biostatistician 2008-2011 NIH R01AG009966 biostatistician 2008-2010 NIH RO1AG011101 epidemiologist 2009-2011 NIH RC2AG036650 biostatistician 2009-2011

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. a contract with the Alzheimer's Association to cover some of the costs of calculating projections of numbers of people with AD in the US

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Paul A. Scherr, PhD, ScD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Rush Institute for Healthy Aging

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Employee of Centers for Disease Control and Prevention (CDC)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kristine Yaffe, MD and
    6. Scientific Advisory Boards:

    1. -Novartis, Inc. - Pfizer -DSMB for Takeda, Inc -DSMB for NIH trials - Beeson Advisory Scientific Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry -Associate Editor 2012-, Journal of Gerontology: Medical Sciences

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH, NIA, NIDDK, NIMH, Department of Defense, California Department of Public Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Bright Focus Foundation and Alzheimer Association's

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. David A. Bennett, MD
    7. Scientific Advisory Boards:

    1. 1) Vigorous Minds, Scientific Advisory Board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Nutricia, paid for travel to scientific meeting

    Editorial Boards:

    1. (1) Neurology, Editorial Board; (2) Current Alzheimer Research, Editorial Board; (3) Neuroepidemiology, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Nutricia, Inc., (2) Eli Lilly, Inc., (3) the Gerson Lehrman Group, (4) Enzymotec Ltd., (5) Double Helix, (6) Takeda Pharmaceuticals USA, Inc

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Nutricia Inc., PI

    Research Support, Government Entities:

    1. NIH: P30AG10161, PI; R01AG15819, PI; R01AG17917, PI; R01AG36042, PI; U01AG32984, Co-I; R01AG22018, Co-I; R01AG33678, Co-I; R01AG36836, Co-I; R01AG41797, Co-I; R01AG42210, Co-I; and Illinois Department Public Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Rush Alzheimer's Disease Center (B.D.J., S.E.L., D.A.B.), Chicago; Departments of Internal Medicine (B.D.J.) and Neurological Sciences (S.E.L., D.A.B.), and Rush Institute on Healthy Aging (L.E.H., P.A.S.), Rush University Medical Center, Chicago, IL; Departments of Psychiatry, Neurology, and Epidemiology (K.Y.), University of California, San Francisco; and San Francisco Veterans Affairs Medical Center (K.Y.), San Francisco, CA.
  1. Correspondence to Dr. James: Bryan_James{at}rush.edu
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Cited By...

Disputes & Debates: Rapid online correspondence

  • Response from authors
    • Bryan D. James, Assistant professor, Rush Alzheimer's Disease Center
    • Bryan James, Sue Leurgans, David Bennett; Chicago, IL
    Submitted March 24, 2014
  • Confusion over Alzheimer Deaths
    • Irene Campbell-Taylor, Clinical Neurologist, Private practice
    • New Waterford, NS
    Submitted March 12, 2014
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