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April 15, 2014; 82 (15) Article

Cardiorespiratory fitness and cognitive function in middle age

The CARDIA Study

Na Zhu, David R. Jacobs, Pamela J. Schreiner, Kristine Yaffe, Nick Bryan, Lenore J. Launer, Rachel A. Whitmer, Stephen Sidney, Ellen Demerath, William Thomas, Claude Bouchard, Ka He, Jared Reis, Barbara Sternfeld
First published April 2, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000310
Na Zhu
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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David R. Jacobs Jr
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Pamela J. Schreiner
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Kristine Yaffe
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Nick Bryan
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Lenore J. Launer
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Rachel A. Whitmer
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Stephen Sidney
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Ellen Demerath
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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William Thomas
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Claude Bouchard
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Ka He
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Jared Reis
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Barbara Sternfeld
From the Divisions of Epidemiology (N.Z., D.R.J., P.J.S., E.D.) and Biostatistics (W.T.), School of Public Health, University of Minnesota, Minneapolis; Department of Nutrition (D.R.J.), University of Oslo, Norway; Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Department of Radiology (N.B.), University of Pennsylvania Health System, Philadelphia; Laboratory of Epidemiology, Demography, and Biometry (L.J.L.), National Institute on Aging, Bethesda, MD; Division of Research (R.A.W., S.S., B.S.), Kaiser Permanente Medical Care Program, Oakland, CA; Human Genomics Laboratory (C.B.), Pennington Biomedical Research Center, Baton Rouge, LA; Epidemiology and Biostatistics Department (K.H.), Indiana University, Bloomington, IN; and Division of Cardiovascular Sciences (J.R.), National Heart, Lung, and Blood Institute, Bethesda, MD.
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Full PDF
Citation
Cardiorespiratory fitness and cognitive function in middle age
The CARDIA Study
Na Zhu, David R. Jacobs, Pamela J. Schreiner, Kristine Yaffe, Nick Bryan, Lenore J. Launer, Rachel A. Whitmer, Stephen Sidney, Ellen Demerath, William Thomas, Claude Bouchard, Ka He, Jared Reis, Barbara Sternfeld
Neurology Apr 2014, 82 (15) 1339-1346; DOI: 10.1212/WNL.0000000000000310

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