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May 06, 2014; 82 (18) ArticleOpen Access

Autoimmune thyroiditis as a risk factor for stroke

A historical cohort study

André Karch, Sara L. Thomas
First published April 9, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000377
André Karch
From the Department of Epidemiology (A.K.), Helmholtz Centre for Infection Research, Braunschweig, Germany; Faculty of Epidemiology & Population Health (A.K., S.L.T.), London School of Hygiene and Tropical Medicine, UK; and Department of Neurology (A.K.), University Medical Center Göttingen, Germany.
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Sara L. Thomas
From the Department of Epidemiology (A.K.), Helmholtz Centre for Infection Research, Braunschweig, Germany; Faculty of Epidemiology & Population Health (A.K., S.L.T.), London School of Hygiene and Tropical Medicine, UK; and Department of Neurology (A.K.), University Medical Center Göttingen, Germany.
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Autoimmune thyroiditis as a risk factor for stroke
A historical cohort study
André Karch, Sara L. Thomas
Neurology May 2014, 82 (18) 1643-1652; DOI: 10.1212/WNL.0000000000000377

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    Figure 1 Flowchart of the selection process for patients with AIT

    AID = autoimmune disease; AIT = autoimmune thyroiditis.

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    Figure 2 Hypothesized interrelationships among AIT, stroke, and other variables

    (A) Conceptual framework for association between AIT and stroke. (B) Differentiation between confounding and mediating effects of factors hypothesized to be on the causal pathway. Presence of factors at the index date was assumed to be attributable to confounding in the primary analysis. AIT = autoimmune thyroiditis; BMI = body mass index; CHD = coronary heart disease; CHF = congestive heart failure.

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    Figure 3 Effect of autoimmune thyroiditis on stroke stratified by time since diagnosis (first thyroxine script)

    *Adjusted for current age, sex, alcohol, smoking, hypertension, atrial fibrillation, hyperlipidemia, and body mass index (all at baseline) and allowing for clustering in practice. **Using a likelihood ratio test to compare a model with against a model without an interaction term for time since diagnosis. CI = confidence interval; RR = rate ratio.

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    Neurology® data supplements are not copyedited before publication. Published editorials and translations have been copyedited.
    © 2014 American Academy of Neurology.

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    Neurology® data supplements are not copyedited before publication. Published editorials and translations have been copyedited.
    © 2015 American Academy of Neurology.

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