Share

June 03, 2014; 82 (22) Article

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

Marco Duering, Benno Gesierich, Stephan Seiler, Lukas Pirpamer, Mariya Gonik, Edith Hofer, Eric Jouvent, Edouard Duchesnay, Hugues Chabriat, Stefan Ropele, Reinhold Schmidt, Martin Dichgans
First published May 2, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000475
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
755

Share

Article Information

vol. 82 no. 22 1946-1950
DOI: 
https://doi.org/10.1212/WNL.0000000000000475
PubMed: 
24793184
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 30, 2013
  • Accepted in final form January 21, 2014
  • First Published May 2, 2014.

Article Versions

Copyright & Usage: 
© 2014 American Academy of Neurology

Author Disclosures

    1. Marco Duering, MD*,
    2. Benno Gesierich, PhD*,
    3. Stephan Seiler, MD,
    4. Lukas Pirpamer,
    5. Mariya Gonik, PhD,
    6. Edith Hofer, PhD,
    7. Eric Jouvent, MD, PhD,
    8. Edouard Duchesnay, PhD,
    9. Hugues Chabriat, MD, PhD,
    10. Stefan Ropele, PhD,
    11. Reinhold Schmidt, MD and
    12. Martin Dichgans, MD
  1. Marco Duering, MD*,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. travel expenses for lectures from the United Leukodystrophy Foundation, the European Stroke Conference and Kenes International

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Vascular Dementia Research Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Benno Gesierich, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Stephan Seiler, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Lundbeck, travel funding

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Rotary Club Innsbruck

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Lukas Pirpamer,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. as reported in the manuscript: This work was supported by the Vascular Dementia Research Foundation, the German Center for Neurodegenerative iseases (DZNE), an FP6 ERA-NET NEURON grant (01 EW1207),3 Fondation Leducq (Transatlantic Network of Excellence on he Pathogenesis of Small Vessel Disease of the Brain) and by the Austrian Science Fund projects P20103 and I904.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Mariya Gonik, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Edith Hofer, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Eric Jouvent, MD, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Edouard Duchesnay, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Hugues Chabriat, MD, PhD,
    10. Scientific Advisory Boards:

    1. Lundbeck, Janssen

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Cerebrovascular disease (member of the editorial board)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Stefan Ropele, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Reinhold Schmidt, MD and
    12. Scientific Advisory Boards:

    1. Rivastigmin Patch, 2010, Novartis JSW Life Sciences 2010, Advisory Board for Dementia Trial Axon Neuroscience 2013

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Received travel expenses and/or honoraria for lectures from Pfizer (2004-2010), Novartis (2003-2010), Merz Austria (2005-2010) and Lundbeck (2004-2009) and for educational activity from Takeda 2010

    Editorial Boards:

    1. Editoral board member of Clinical Neurology and Neurosurgery 2004-currently

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Pfizer 2004-2010,lectures Novartis 2003-2010, lectures Merz Austria 2005-2010, lectures Lundbeck 2004-2009, lectures Takeda, 2010, teaching course

    Consultancies:

    1. QPS, Austria Axon Neuroscience

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Austrian Science Fund projects P20103 and I904

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Martin Dichgans, MD
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Bayer Vital, travel expenses and honoraria for lectures, (2) Boehringer Ingelheim Pharma, travel expenses and honoraria for lectures, (3) Heel, travel expenses and honoraria for lectures, (4) Bristol-Meyer Squibb, travel expenses and honoraria for lectures, (5) Lundeck, travel expenses and honoraria for lectures, (6) Sanofi-Aventis, travel expenses and honoraria for lectures, (7) Shire, travel expenses and honoraria for lectures, (8) German Research Foundation (DFG), research support, (9) Vascular Dementia Research Foundation, research support, (10) Corona Foundation, research support, (11) Jackst�dt Foundation, research support.

    Editorial Boards:

    1. (1) Stroke the International Journal of Stroke, editor, (2) Cerebrovascular diseases, editorial board member, (3) Journal of Neurochemistry, editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Bayer Vital, (2) Boehringer Ingelheim, (3) Bristol-Meyer Squibb, (4) Heel

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Wellcometrust, 03/08 following, (2) European Union (EU FP 7), investigator, 10/13-09/16, (3) German Federal Ministry of Education and Research (BMBF), investigator, 12/13-11/16, (4) European Union (EU FP 6), investigator, 03/12-02/15

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Vascular Dementia Research Foundation, (2) Corona Foundation, (3) Jackst�dt Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Institute for Stroke and Dementia Research (M. Duering, B.G., M.G., M. Dichgans), Klinikum der Universität München, Munich, Germany; the Department of Neurology (S.S., L.P., E.H., S.R., R.S.), Medical University of Graz; the Institute for Medical Informatics, Statistics and Documentation (E.H.), Graz, Austria; the Department of Neurology (E.J., H.C.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris; Neurospin (E.D.), CEA Saclay, Gif sur Yvette, France; the German Center for Neurodegenerative Diseases (DZNE, Munich) (M. Dichgans); and Munich Cluster for Systems Neurology (SyNergy) (M. Dichgans), Munich, Germany.
  1. Correspondence to Dr. Dichgans: martin.dichgans{at}med.uni-muenchen.de
View Full Text

Article usage

Article usage: May 2014 to December 2021

AbstractFullPdfSource
May 2014510149Highwire
Jun 2014197158113Highwire
Jul 20142871134Highwire
Aug 2014871421Highwire
Sep 2014711812Highwire
Oct 2014701015Highwire
Nov 201480013Highwire
Dec 20142523Highwire
Jan 20157843Highwire
Jan 201502720pmc
Feb 20153145Highwire
Feb 201501714pmc
Mar 20158012Highwire
Mar 201501714pmc
Apr 20152334Highwire
Apr 201501614pmc
May 20152922Highwire
May 201502113pmc
Jun 20153065Highwire
Jun 20150168pmc
Jul 20153811Highwire
Jul 2015095pmc
Aug 20153733Highwire
Aug 20150129pmc
Sep 20154500Highwire
Sep 20150159pmc
Oct 20154622Highwire
Oct 201502415pmc
Nov 20152913Highwire
Nov 20150119pmc
Dec 20152500Highwire
Dec 2015098pmc
Jan 20163822Highwire
Jan 201602113pmc
Feb 20162003Highwire
Feb 201601410pmc
Mar 20163123Highwire
Mar 20160118pmc
Apr 20162133Highwire
Apr 2016086pmc
May 20164312Highwire
May 20160105pmc
Jun 20161732Highwire
Jun 20160116pmc
Jul 20163500Highwire
Jul 2016084pmc
Aug 20162800Highwire
Aug 2016077pmc
Sep 20162411Highwire
Sep 2016064pmc
Oct 20162400Highwire
Oct 201601410pmc
Nov 20162522Highwire
Nov 2016084pmc
Dec 20163101Highwire
Dec 20160127pmc
Jan 20172000Highwire
Jan 20170128pmc
Feb 20171501Highwire
Feb 2017054pmc
Mar 20172823Highwire
Mar 20170135pmc
Apr 20173200Highwire
Apr 201741212pmc
May 20173510Highwire
May 2017386pmc
Jun 20173221Highwire
Jun 201791313pmc
Jul 20171900Highwire
Jul 2017466pmc
Aug 20172311Highwire
Aug 201771213pmc
Sep 2017700Highwire
Sep 2017499pmc
Oct 20171213Highwire
Oct 201781418pmc
Nov 20171311Highwire
Nov 2017577pmc
Dec 20174213Highwire
Jan 20183841Highwire
Feb 20183100Highwire
Mar 20182511Highwire
Apr 20183400Highwire
Apr 201841315pmc
May 20182070Highwire
Jun 20184353Highwire
Jun 201811515pmc
Jul 20181812Highwire
Aug 20181900Highwire
Aug 201841213pmc
Sep 20182010Highwire
Oct 20183352Highwire
Nov 20182700Highwire
Dec 20183110Highwire
Jan 20191733Highwire
Feb 20192733Highwire
Mar 20191633Highwire
Apr 20191123Highwire
May 20192112Highwire
Jun 20195521Highwire
Jul 20192411Highwire
Aug 20191222Highwire
Sep 2019610Highwire
Oct 20194920Highwire
Nov 20192203Highwire
Dec 20192103Highwire
Jan 20202164Highwire
Feb 20203000Highwire
Mar 20202700Highwire
Apr 20202152Highwire
May 20201843Highwire
Jun 20201600Highwire
Jul 20201521Highwire
Aug 20201830Highwire
Sep 20202200Highwire
Oct 20204632Highwire
Nov 20205012Highwire
Dec 20203301Highwire
Jan 20215021Highwire
Feb 20213075Highwire
Mar 20213731Highwire
Apr 20214421Highwire
May 20215254Highwire
Jun 20214221Highwire
Jul 20216042Highwire
Aug 20215520Highwire
Sep 20213011Highwire
Oct 20215020Highwire
Nov 20213242Highwire
Dec 20213721Highwire

Cited By...

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Related Articles

Topics Discussed

Alert Me