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September 02, 2014; 83 (10) NeuroImages

Intraventricular tumor presenting as progressive supranuclear palsy–like phenotype

Maurizio Morelli, Francesco Fera, Francesco Bono, Alessandra Fratto, Gennarina Arabia, Aldo Quattrone
First published September 1, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000748
Maurizio Morelli
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Francesco Fera
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Francesco Bono
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Alessandra Fratto
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Gennarina Arabia
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Aldo Quattrone
From the Institute of Neurology (M.M., F.B., A.F., G.A., A.Q.), University Magna Graecia, Catanzaro, Italy; and the Neuroimaging Research Unit (F.F., A.Q.), National Research Council, Catanzaro, Italy.
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Intraventricular tumor presenting as progressive supranuclear palsy–like phenotype
Maurizio Morelli, Francesco Fera, Francesco Bono, Alessandra Fratto, Gennarina Arabia, Aldo Quattrone
Neurology Sep 2014, 83 (10) 948; DOI: 10.1212/WNL.0000000000000748

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A 70-year-old woman presented with a 2-year history of progressive difficulty in walking with frequent falls. Neurologic examination showed postural instability with backward falls, vertical supranuclear gaze palsy with normal vestibular-ocular reflex, rigidity, and pyramidal signs in the right limbs. There was no clinical response to levodopa. Laboratory serologic tests had normal results. MRI displayed midbrain compression and dislocation caused by a large tumor in the left lateral ventricle (figure). Dopamine transporter SPECT showed normal striatal binding. The patient died before neurosurgery could be performed; there was no autopsy. Brain tumors should be considered in the diagnostic workup1 of progressive supranuclear palsy–like phenotypes.

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Figure 3 Tesla brain MRI findings

Sagittal T1-weighted images (A, B): midbrain compression caused by a globular tumor. Axial fluid-attenuated inversion recovery (FLAIR) image (C): left lateral ventricle enlargement; vascular pedicle connecting the tumor to the choroidal plexus (arrow). Axial-GE-T2* image (D): tumor hypointensity by mineral accumulation. Coronal FLAIR image (E): left cerebral peduncle dislocation and transependymal CSF diffusion.

Footnotes

  • Author contributions: Dr. Morelli: drafting the manuscript, acquisition of data, analysis and interpretation of data, accepts responsibility for conduct of research and final approval. Dr. Fera: acquisition of data, analysis and interpretation of data, accepts responsibility for conduct of research and final approval. Francesco Bono: acquisition of data, accepts responsibility for conduct of research and final approval. Dr. Fratto: acquisition of data, accepts responsibility for conduct of research and final approval. Dr. Arabia: acquisition of data, accepts responsibility for conduct of research and final approval. Dr. Quattrone: corresponding author; study concept and design, drafting/revising the manuscript, study supervision, accepts responsibility for conduct of research and final approval.

  • Study funding: No targeted funding reported.

  • Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

  • © 2014 American Academy of Neurology

References

  1. 1.↵
    1. Lewerenz J,
    2. Zurowski B,
    3. Jenicke L,
    4. Bäumer T,
    5. Lees AJ,
    6. Münchau A
    . Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy. Mov Disord 2005;20:1071–1075.
    OpenUrlPubMed
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