Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

September 23, 2014; 83 (13) Views & Reviews

Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders

Sharmilee Gnanapavan, Harald Hegen, Michael Khalil, Bernhard Hemmer, Diego Franciotta, Steve Hughes, Rogier Hintzen, Andreas Jeromin, Eva Havrdova, Hayrettin Tumani, Antonio Bertolotto, Manuel Comabella, Jette Frederiksen, José C. Álvarez-Cermeño, Luisa Villar, Daniela Galimberti, Kjell-Morten Myhr, Irena Dujmovic, Franz Fazekas, Carolina Ionete, Til Menge, Jens Kuhle, Geoffrey Keir, Florian Deisenhammer, Charlotte Teunissen, Gavin Giovannoni
First published August 22, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000809
Sharmilee Gnanapavan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harald Hegen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Khalil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernhard Hemmer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diego Franciotta
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Steve Hughes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rogier Hintzen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Jeromin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eva Havrdova
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hayrettin Tumani
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonio Bertolotto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manuel Comabella
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jette Frederiksen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
José C. Álvarez-Cermeño
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luisa Villar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniela Galimberti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kjell-Morten Myhr
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irena Dujmovic
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Franz Fazekas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolina Ionete
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Til Menge
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jens Kuhle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Geoffrey Keir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Florian Deisenhammer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charlotte Teunissen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gavin Giovannoni
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders
Sharmilee Gnanapavan, Harald Hegen, Michael Khalil, Bernhard Hemmer, Diego Franciotta, Steve Hughes, Rogier Hintzen, Andreas Jeromin, Eva Havrdova, Hayrettin Tumani, Antonio Bertolotto, Manuel Comabella, Jette Frederiksen, José C. Álvarez-Cermeño, Luisa Villar, Daniela Galimberti, Kjell-Morten Myhr, Irena Dujmovic, Franz Fazekas, Carolina Ionete, Til Menge, Jens Kuhle, Geoffrey Keir, Florian Deisenhammer, Charlotte Teunissen, Gavin Giovannoni
Neurology Sep 2014, 83 (13) 1210-1216; DOI: 10.1212/WNL.0000000000000809

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
391

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: The aim of these guidelines is to make the process of reporting body fluid biomarker studies in neurologic disorders more uniform and transparent, in line with existing standards for reporting research in other biomedical areas. Although biomarkers have been around for decades, there are concerns over the high attrition rate of promising candidate biomarkers at later phases of development.

Methods: BioMS-eu consortium, a collaborative network working toward improving the quality of biomarker research in neurologic disorders, discussed the merits of standardizing the reporting of body fluid biomarker research. A checklist of items integrating the results of other published guidances, literature, conferences, regulatory opinion, and personal expertise was created to ultimately form a structured summary guidance incorporating the key features.

Results: The summary guidance is comprised of a 10-point uniform reporting format ranging from introduction, materials and methods, through to results and discussion. Each item is discussed in detail in the guidance report.

Conclusions: To enhance the future development of body fluid biomarkers, it will be important to standardize the reporting of studies. This guideline by the BioMS-eu consortium is aimed at setting a standard for the reporting of future body fluid biomarker research studies in neurologic disorders. We anticipate that following these guidelines will help to accelerate the selection of biomarkers for clinical development.

GLOSSARY

MS=
multiple sclerosis

Footnotes

  • Authors' affiliations are listed at the end of the article.

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial, page 1130

  • Supplemental data at Neurology.org

  • Received September 2, 2013.
  • Accepted in final form June 27, 2014.
  • © 2014 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR AFFILIATIONS
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Related Articles

  • Biomarkers for neurologyGuides and lines

Alert Me

  • Alert me when eletters are published
Neurology: 98 (21)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise