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September 30, 2014; 83 (14) Article

ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort

Kristine S. Alexander, Neil A. Zakai, Sarah Gillett, Leslie A. McClure, Virginia Wadley, Fred Unverzagt, Mary Cushman
First published September 10, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000844
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Article Information

vol. 83 no. 14 1271-1276
DOI: 
https://doi.org/10.1212/WNL.0000000000000844
PubMed: 
25209581
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received April 17, 2014
  • Accepted in final form July 3, 2014
  • First Published September 10, 2014.

Article Versions

Copyright & Usage: 
© 2014 American Academy of Neurology

Author Disclosures

    1. Kristine S. Alexander, PhD, MCR,
    2. Neil A. Zakai, MD, MSc,
    3. Sarah Gillett, PhD,
    4. Leslie A. McClure, PhD,
    5. Virginia Wadley, PhD,
    6. Fred Unverzagt, PhD and
    7. Mary Cushman, MD, MSc
  1. Kristine S. Alexander, PhD, MCR,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1)NIH Thrombosis and Hemostasis Training Grant, 5T32HL007594, postdoctoral trainee, 2012-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Neil A. Zakai, MD, MSc,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1. Circulation 2011- Guest Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH / NHLBI (K08HL096841)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Sarah Gillett, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Leslie A. McClure, PhD,
    5. Scientific Advisory Boards:

    1. (1) NIH/NINDS

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH U01 NS41588, co-I

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Virginia Wadley, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Alzheimer's Association travel expenses for Patient- related Outcomes speaking engagement

    Editorial Boards:

    1. Current Gerontology and Geriatrics Research, editoral board, 2010-present, no compensation Journal of Aging Science, editorial board, 2013-present, no compensation

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Genzyme, a Sanofi Corporation, investigator-initiated grant, PI

    Research Support, Government Entities:

    1. (1)NIH, NO1 HC48047, Co-I, 1989-2013 (2)NIH, U01 NS51488, Co-I, 2007-2017 (3)NIH, R01 NS061846,Co-I, 2008-2013 (4)NIH, P30 AG022838,Co-I,2009-2014 (5)NIH, HHSN268200900047C, Co-I, 2009�2018 (6)NIH, R01 AG021958, Co-I, 2009�2014 (7)NIH, R01 AG039588, Co-I, 2011-2016 (8)NIH, R01 NS080850, Co-I, 2012-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Fred Unverzagt, PhD and
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1) Neuropsychology, Editorial Board, 2007-present 2) Journal of the International Neuropsychological Society, Editorial Board, 20014-present 3) Current Alzheimer Research, Editorial Board, 2013- present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) UCB Pharma 2) Piramal Life Science

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Research support from Posit Science, Inc., in the form of site licenses for cognitive training programs for investigator-initiated research projects.

    Research Support, Government Entities:

    1. R01 AG045157 R01 AG019181 U01 NS041588 P30 AG10133 UL 1RR025761

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Eli Lilly, Inc.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Consultant and expert witness testimony in medicolegal tort cases.

  7. Mary Cushman, MD, MSc
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. I am an Associate Editor for Journal of Thrombosis and Haemostasis since 2007. I am Senior Geust Editor for Circulation since 2011.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I have received reesarch support from Amgen for this study, but not this paper, more than two years ago. I receive research support from diaDexus

    Research Support, Government Entities:

    1. I have recevied numerous NIH grants for the study of vascular disease epidemiology, including the grant that funded the REGARDS parent study (from NINDS)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Medicine (K.S.A., N.A.Z., S.G., M.C.) and Pathology (N.A.Z., M.C.), University of Vermont, Burlington; School of Public Health (L.A.M.) and Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine (V.W.), University of Alabama at Birmingham; and Department of Psychiatry (F.U.), Indiana University School of Medicine, Indianapolis.
  1. Correspondence to Dr. Cushman: mary.cushman{at}uvm.edu
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