Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

October 07, 2014; 83 (15) Article

Influence of BDNF Val66Met on the relationship between physical activity and brain volume

Belinda M. Brown, Pierrick Bourgeat, Jeremiah J. Peiffer, Samantha Burnham, Simon M. Laws, Stephanie R. Rainey-Smith, David Bartrés-Faz, Victor L. Villemagne, Kevin Taddei, Alan Rembach, Ashley Bush, Kathryn A. Ellis, S. Lance Macaulay, Christopher C. Rowe, David Ames, Colin L. Masters, Paul Maruff, Ralph N. Martins, For the AIBL Research Group
First published September 3, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000867
Belinda M. Brown
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pierrick Bourgeat
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeremiah J. Peiffer
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samantha Burnham
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon M. Laws
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephanie R. Rainey-Smith
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Bartrés-Faz
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor L. Villemagne
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kevin Taddei
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Rembach
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ashley Bush
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathryn A. Ellis
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Lance Macaulay
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher C. Rowe
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Ames
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Colin L. Masters
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Maruff
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph N. Martins
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre—BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia; Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain; The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia.
Full PDF
Citation
Influence of BDNF Val66Met on the relationship between physical activity and brain volume
Belinda M. Brown, Pierrick Bourgeat, Jeremiah J. Peiffer, Samantha Burnham, Simon M. Laws, Stephanie R. Rainey-Smith, David Bartrés-Faz, Victor L. Villemagne, Kevin Taddei, Alan Rembach, Ashley Bush, Kathryn A. Ellis, S. Lance Macaulay, Christopher C. Rowe, David Ames, Colin L. Masters, Paul Maruff, Ralph N. Martins, For the AIBL Research Group
Neurology Oct 2014, 83 (15) 1345-1352; DOI: 10.1212/WNL.0000000000000867

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
246

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.

Methods: This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.

Results: The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = −0.22, p = 0.02) and temporal lobe (β = −0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.

Conclusion: The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.

GLOSSARY

AD=
Alzheimer disease;
AIBL=
Australian Imaging, Biomarkers and Lifestyle;
BDNF=
brain-derived neurotrophic factor;
ICV=
intracranial volume;
IPAQ=
International Physical Activity Questionnaire;
Met=
methionine;
MET=
metabolic equivalent;
ROI=
region of interest;
T1W=
T1-weighted;
Val=
valine

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • AIBL Research Group coinvestigators are listed on the Neurology® Web site at Neurology.org.

  • Supplemental data at Neurology.org

  • Received March 30, 2014.
  • Accepted in final form July 3, 2014.
  • © 2014 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Brain Metabolism Related to Mild Cognitive Impairment and Phenoconversion in Patients With Isolated REM Sleep Behavior Disorder

Dr. David E. Vaillancourt and Dr. Shannon Y. Chiu

► Watch

Topics Discussed

  • All Genetics
  • Alzheimer's disease
  • Volumetric MRI

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Clinical Implications of Neuroscience Research
    Brain-derived neurotrophic factor
    Regulation, effects, and potential clinical relevance
    Eduardo E. Benarroch et al.
    Neurology, March 27, 2015
  • Article
    BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention
    Elizabeth A. Boots, Stephanie A. Schultz, Lindsay R. Clark et al.
    Neurology, May 03, 2017
  • Article
    Physical activity and hippocampal volume in middle-aged patients with type 1 diabetes
    Karen A. Nunley, Regina L. Leckie, Trevor J. Orchard et al.
    Neurology, March 10, 2017
  • Articles
    Physical activity and the risk of Parkinson disease
    H. Chen, S. M. Zhang, M. A. Schwarzschild et al.
    Neurology, February 22, 2005
Neurology: 100 (21)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise