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October 07, 2014; 83 (15) Article

Self-reported memory complaints

Implications from a longitudinal cohort with autopsies

Richard J. Kryscio, Erin L. Abner, Gregory E. Cooper, David W. Fardo, Gregory A. Jicha, Peter T. Nelson, Charles D. Smith, Linda J. Van Eldik, Lijie Wan, Frederick A. Schmitt
First published September 24, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000856
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Article Information

vol. 83 no. 15 1359-1365
DOI: 
https://doi.org/10.1212/WNL.0000000000000856
PubMed: 
25253756
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 19, 2013
  • Accepted in final form July 12, 2014
  • First Published September 24, 2014.

Article Versions

Copyright & Usage: 
© 2014 American Academy of Neurology

Author Disclosures

    1. Richard J. Kryscio, PhD,
    2. Erin L. Abner, PhD,
    3. Gregory E. Cooper, MD, PhD,
    4. David W. Fardo, PhD,
    5. Gregory A. Jicha, MD, PhD,
    6. Peter T. Nelson, MD, PhD,
    7. Charles D. Smith, MD,
    8. Linda J. Van Eldik, PhD,
    9. Lijie Wan and
    10. Frederick A. Schmitt, PhD
  1. Richard J. Kryscio, PhD,
    2. Scientific Advisory Boards:

    1. Scientific Advisory board, ALLTECH Inc.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor, Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Alzheimer Disease Center Core grant: AG028383, 7/11 - 6/16 Associate Director; Core Leader: Biostatistics and Data Management National Institute on Aging grants R01 AG0386561-01A1, 07/11-06/16, P.I. P01AG05119, 4/08 - 3/13, co-investigator R01AG019241, 9/01 -2/13, co-P.I. R03AG032099, 6/10 - 5/12, co-investigator R21AG036875, 6/10 - 5/12, co-investigator National Center for Research Resources P20RR020145, 9/04 - 7/14, Leader Biostatistcs and Bioinformatics Core U54 RR031263, 7/11 - 6/16, Leader, Biostatistcs, Epidemiology, and Research Design National Institute on Drug Abuse P50DA005312, 9/06 - 6/12, co-investigator National Institute of Neurological Diseases & Stroke P01NS058484, 5/09 - 4/12, co-investigator National Institute of child health & Human Development R01HD064993, 9/09-8/14, co-investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Erin L. Abner, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Alltech Life Sciences

    Research Support, Government Entities:

    1. (1) NIA P30 AG028383, Co-investigator, 2006-present (2) NIA R01 AG019241, Co-investigator, 2006-present (3) NIA R01 AG038651, Co-investigator, 2011-present (4) NIH R01 NR014189, Co-investigator, 2013-present (5) NIH R01 HD064993, Co-investigator, 2013-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Gregory E. Cooper, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Pfizer Speakers Bureau (2007-2009); Forest Pharmaceuticals Speakers Bureau (2007-2014)

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Grant funding from Eli Lilly (2008-present), Myriad Pharmaceuticals (2007-2009)

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Provided expert consultation regarding nursing home care of patients with dementia;

  4. David W. Fardo, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Pediatric Genetics, Statistical Editor, 2010-present (2) Frontiers in Applied Genetic Epidemiology, Review Editor, 2011-present (3) Journal of Biometrics and Biostatistics, Editorial Board, 2012-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Brigham Young University (2) Commonwealth Center for Governance Studies, Inc.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH/NIA, K25 AG043546, PI, 2013-present (2) NIH/NIA, P30 AG028383, Biostatistics and Data Management, 2012-2013 (3) NIH/NIA, R01 AG038651, Co-I, 2012-2013 (4) NIH/NIDCR, R03 DE021438, Co-I, 2012-2013 (5) NIH/NIGMS, P20 GM103436, Co-I, 2012-2013 (6) NIH/NIGMS, P20 GM103538, Co-I, 2012-2013 (7) NIH/NIA, R01 AG019241, Co-I, 2012-2013

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Gregory A. Jicha, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1)Journal of International Clinical and Experimental Medicine, Associate Editor, 2011-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Pfizer Jannsen Lilly Alltech Baxter Esai

    Research Support, Government Entities:

    1. P30AG028383, R01AG019241, R01HD064993, R01NR014189, R01AG038651, UL1TR000117, U01AG010483

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Peter T. Nelson, MD, PhD,
    7. Scientific Advisory Boards:

    1. Mayo Jacksonville Udall Ctr

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Acta Neuropathologica JNEN

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 5P30AG028383-08 (Van Eldik, PI) 7/01/2006 -06/30/2016 2.4 calendar NIH/NIA $854,767 Alzheimer�s Disease Center The major goal of this project is to build on the existing broad-based AD program to gain an understanding of pathogenic mechanisms in AD with the eventual goal of prevention and treatment of the disease. No overlap. 5R01AG0386561-02 (Kryscio & Schmitt, PIs) 9/01/11- 8/31/16 1.20 calendar NIH/NIA $502,948 Role of impaired cognitive states & risk factors in conversion to mixed dementias Combine data from six centers having longitudinal cohorts assessed for cognitive status annually and followed to dementia with autopsy upon death. Use of innovative Markov model to risk factors to the flow of elderly subjects through impaired cognitive states and correlate with neuropathological assessment of the brain upon autopsy. No overlap. 5R01NR014189-02 (G. Jicha, D. Moser) 09/01/2012 � 08/31/2017 0.60 calendar NIH/NINR $270,423 Early Detection and Prevention of Mild Cognitive Impairment due to cerebrovascular A multidisciplinary approach to studying MCI related to cerebral vascular disease. No overlap. R56NS061933-05A1 (Nelson) 09/28/2012- 08/31/2014 1.20 calendar NIH/NIA $250,000MIR-15/107 micrornas are important genetic regulators in Alzheimer disease This is a no-cost extension with a prior R01 that highlighted the impact of miR-15/107 miRNAs in AD according to biosamples from a brain bank, and from tissue culture experimental systems. No overlap. 1R01AG042419-01A1 (G. Jicha, P. Nelson) 07/15/2013 � 06/30/2016 1.20 calendar NIH/NIA $352,667 Modulation of microRNA pathways by gemfibrozil in predementia Alzheimer disease Basically a small-scale clinical trial for gemfibrozil, studying mechanisms of action and biodistribution. No overlap. 1R21NS085830-01 (Nelson) 09/01/2013 � 08/31/2015 0.48 calendar NINDS /NIH $150,000 Sexually dimorphic miR-497 regulates alpha-synuclein and alpha-synucleinopathy Study of a miRNA in connection with dementia with Lewy bodies. No overlap.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Charles D. Smith, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Neuronetrix, Inc., (2) AmGen, Inc.

    Research Support, Government Entities:

    1. (1) NIH/NIA P50 AG 5119 Satellite PI, (2) NIH/NIA T32 000242 Faculty, (3) NIH/NIA U01 AG024904 Site PI, (4) NIH/NIMH R01MH078228 Co-investigator, (5) NIH/NCRR (Shared Instrumentation) 1S10RR024553 PI, (6) NIH/NIMH R01MH063817-04 Co-investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Linda J. Van Eldik, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Journal of Neuroinflammation, editorial board member, 2003-present. (2) Journal of Neuroimmune Pharmacology, editorial board member, 2007-present. (3) American Journal of Neurodegenerative Disease, editorial board member, 2012-present.

    Patents:

    1. (1) Synthetic peptides and use in preparing calmodulin antisera. (2) Several patents for composition and use of pyridazine compounds.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH R01 NS064247, Principal investigator, 2010-2014 (2) NIH P30 AG028383, Principal investigator, 2010-2016 (3) Kentucky Spinal Cord & Brain Injury Research Trust 12-20A research grant, Principal investigator, 2013-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Thome Memorial Foundation research award, Principal investigator, 2010-2014

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Lijie Wan and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Frederick A. Schmitt, PhD
    11. Scientific Advisory Boards:

    1. Scientific Advisory board, ALLTECH Inc.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor, Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Alzheimer Disease Center Core grant: AG028383, 7/11 - 6/16 Associate Director; Core Leader: Biostatistics and Data Management National Institute on Aging grants R01 AG0386561-01A1, 07/11-06/16, P.I. P01AG05119, 4/08 - 3/13, co-investigator R01AG019241, 9/01 -2/13, co-P.I. R03AG032099, 6/10 - 5/12, co-investigator R21AG036875, 6/10 - 5/12, co-investigator National Center for Research Resources P20RR020145, 9/04 - 7/14, Leader Biostatistcs and Bioinformatics Core U54 RR031263, 7/11 - 6/16, Leader, Biostatistcs, Epidemiology, and Research Design National Institute on Drug Abuse P50DA005312, 9/06 - 6/12, co-investigator National Institute of Neurological Diseases & Stroke P01NS058484, 5/09 - 4/12, co-investigator National Institute of child health & Human Development R01HD064993, 9/09-8/14, co-investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Sanders-Brown Center on Aging (R.J.K., E.L.A., G.E.C., G.A.J., P.T.N., C.D.S., L.J.V.E., L.W., F.A.S.), Alzheimer's Disease Center (R.J.K., E.L.A., G.E.C., D.W.F., G.A.J., P.T.N., C.D.S., L.J.V.E., F.A.S.), Departments of Biostatistics (R.J.K., D.W.F.), Statistics (R.J.K., L.W.), Epidemiology (E.L.A.), and Pathology (P.T.N.), Department of Anatomy and Neurobiology, College of Medicine (L.J.V.E.), and Department of Neurology, College of Medicine (G.A.J., C.D.S., F.A.S.), University of Kentucky, Lexington; and Baptist Neurology Center (G.E.C.), Lexington, KY.
  1. Correspondence to Dr. Kryscio: kryscio{at}email.uky.edu
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