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November 11, 2014; 83 (20) Article

Plasma lipids and cerebral small vessel disease

Sabrina Schilling, Christophe Tzourio, Carole Dufouil, Yicheng Zhu, Claudine Berr, Annick Alpérovitch, Fabrice Crivello, Bernard Mazoyer, Stéphanie Debette
First published October 15, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000980
Sabrina Schilling
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Christophe Tzourio
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Carole Dufouil
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Yicheng Zhu
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Claudine Berr
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Annick Alpérovitch
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Fabrice Crivello
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Bernard Mazoyer
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Stéphanie Debette
From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
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Full PDF
Citation
Plasma lipids and cerebral small vessel disease
Sabrina Schilling, Christophe Tzourio, Carole Dufouil, Yicheng Zhu, Claudine Berr, Annick Alpérovitch, Fabrice Crivello, Bernard Mazoyer, Stéphanie Debette
Neurology Nov 2014, 83 (20) 1844-1852; DOI: 10.1212/WNL.0000000000000980

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Article Information

vol. 83 no. 20 1844-1852
DOI: 
https://doi.org/10.1212/WNL.0000000000000980
PubMed: 
25320101

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 27, 2014
  • Accepted in final form August 13, 2014
  • First Published October 15, 2014.

Article Versions

  • Previous version (October 15, 2014 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2014 American Academy of Neurology

Author Disclosures

    1. Sabrina Schilling, MSc,
    2. Christophe Tzourio, MD, PhD,
    3. Carole Dufouil, PhD,
    4. Yicheng Zhu, MD, PhD,
    5. Claudine Berr, MD, PhD,
    6. Annick Alpérovitch, MD, MSc,
    7. Fabrice Crivello, PhD,
    8. Bernard Mazoyer, MD, PhD and
    9. Stéphanie Debette, MD, PhD
  1. Sabrina Schilling, MSc,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Christophe Tzourio, MD, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Member editorial board of Neuroepidemiology (2005-) Member editorial board of J Hypertension(2010-) Associate editor Journal of Universal Rejection (2011-)

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. Agence Nationale de la Recherche

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Fondation Plan Alzheimer

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Carole Dufouil, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. Honoraria from the American Academy of Neurology for educational lectures

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Yicheng Zhu, MD, PhD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. receiving research support from National Key Technology R&D Program in the 12th Five year Plan of China. Grant number: 2011BAI08B03

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Claudine Berr, MD, PhD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Menber of editorial advisory board Revue Epid�miologie et Sant� publique Associate editor British Journal of Nutrition

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. Agence Nationale de la Recherche, France Fondation Plan Alzheimer, France

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Annick Alpérovitch, MD, MSc,
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Commercial entity: LA-SER, Paris

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Fabrice Crivello, PhD,
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  15. Bernard Mazoyer, MD, PhD and
  16. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  17. Stéphanie Debette, MD, PhD
  18. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. editorial board of stroke

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. Agence Nationale de la Recherche (French National Research Agency): chaire d'excellence junior 2010-2014; VASCOGENE project 2015-2020

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Leducq Foundation

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the University of Bordeaux Ségalen (S.S., C.T., C.D., Y.Z., A.A., S.D.), INSERM U897 Neuroepidemiology, Bordeaux, France; Pekin Union Medical College Hospital (Y.Z.), China; Inserm U1061(C.B.), Montpellier; University Montpellier I (C.B.); University Pierre et Marie Curie–Paris 6 (A.A.); CNRS-CEA UMR5296 (F.C., B.M.), Université Bordeaux Segalen, Bordeaux; University of Versailles Saint-Quentin-en-Yvelines (S.D.); Department of Neurology (S.D.), Lariboisière Hospital, Paris; INSERM UMR S-1161 (S.D.), Paris 7 University, France; Department of Neurology (S.D.), Bordeaux University Hospital, Bordeaux; and Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
  1. Correspondence to Dr. Debette: Stephanie.Debette{at}isped.u-bordeaux2.fr or Dr. Tzourio: christophe.tzourio{at}u-bordeaux2.fr
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