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August 05, 2014; 83 (6) Editorial

How predictive of dementia are inflammatory biomarkers in late midlife?

Mario Di Napoli, Jeremy M. Silverman
First published July 2, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000662
Mario Di Napoli
From the Neurological Service (M.D.N.), San Camillo de' Lellis General Hospital, Rieti, Italy; and the Department of Psychiatry (J.M.S.), Icahn School of Medicine at Mount Sinai, New York, NY.
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Jeremy M. Silverman
From the Neurological Service (M.D.N.), San Camillo de' Lellis General Hospital, Rieti, Italy; and the Department of Psychiatry (J.M.S.), Icahn School of Medicine at Mount Sinai, New York, NY.
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How predictive of dementia are inflammatory biomarkers in late midlife?
Mario Di Napoli, Jeremy M. Silverman
Neurology Aug 2014, 83 (6) 478-479; DOI: 10.1212/WNL.0000000000000662

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Few topics in neurology have generated as much recent debate as the use of biomarkers in prediction of cognitive decline and dementia in cognitively normal individuals. Since substantial brain damage has already occurred by the time a clinical diagnosis of dementia is made, this may be too late for any effective intervention. Inflammatory markers have been identified as potentially useful biomarkers in predicting and monitoring progression of cognitive decline until dementia.1

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  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • Editorial, page 480

  • See page 486

  • © 2014 American Academy of Neurology
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