August 26, 2014; 83 (9) Views & Reviews
Recommendations of the Alzheimer's Disease–Related Dementias Conference
Thomas J. Montine, Walter J. Koroshetz, Debra Babcock, Dennis W. Dickson, Wendy R. Galpern, M. Maria Glymour, Steven M. Greenberg, Michael L. Hutton, David S. Knopman, Andrey N. Kuzmichev, Jennifer J. Manly, Karen S. Marder, Bruce L. Miller, Creighton H. Phelps, William W. Seeley, Beth-Anne Sieber, Nina B. Silverberg, Margaret Sutherland, Christine L. Torborg, Salina P. Waddy, Berislav V. Zlokovic, Roderick A. Corriveau, For the ADRD 2013 Conference Organizing Committee
First published July 30, 2014, DOI: https://doi.org/10.1212/WNL.0000000000000733
Thomas J. Montine
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Walter J. Koroshetz
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Debra Babcock
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Dennis W. Dickson
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Wendy R. Galpern
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
M. Maria Glymour
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Steven M. Greenberg
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Michael L. Hutton
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
David S. Knopman
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Andrey N. Kuzmichev
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Jennifer J. Manly
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Karen S. Marder
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Bruce L. Miller
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Creighton H. Phelps
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
William W. Seeley
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Beth-Anne Sieber
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Nina B. Silverberg
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Margaret Sutherland
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Christine L. Torborg
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Salina P. Waddy
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Berislav V. Zlokovic
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Roderick A. Corriveau
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.
Recommendations of the Alzheimer's Disease–Related Dementias Conference
Thomas J. Montine, Walter J. Koroshetz, Debra Babcock, Dennis W. Dickson, Wendy R. Galpern, M. Maria Glymour, Steven M. Greenberg, Michael L. Hutton, David S. Knopman, Andrey N. Kuzmichev, Jennifer J. Manly, Karen S. Marder, Bruce L. Miller, Creighton H. Phelps, William W. Seeley, Beth-Anne Sieber, Nina B. Silverberg, Margaret Sutherland, Christine L. Torborg, Salina P. Waddy, Berislav V. Zlokovic, Roderick A. Corriveau, For the ADRD 2013 Conference Organizing Committee
Neurology Aug 2014, 83 (9) 851-860; DOI: 10.1212/WNL.0000000000000733
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Abstract
The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. In the Plan, the term Alzheimer disease includes not only Alzheimer disease (AD) proper, but also several specified related dementias, namely, frontotemporal, Lewy body, vascular, and mixed dementia. In response to a specific action item in the 2012 National Plan, the National Institute of Neurological Disorders and Stroke, in collaboration with the National Institute on Aging, convened panels of experts and conducted a 2-day public conference to develop research priorities and timelines for addressing Alzheimer disease–related dementias (ADRD) in 5 topic areas: multiple etiology dementias, health disparities, Lewy body dementias including dementia with Lewy bodies and Parkinson disease dementia, frontotemporal dementia and related tauopathies, and vascular contributions to ADRD. By design, the product was up to 8 prioritized research recommendations in each topic area including estimated timelines from when work on a recommendation is started to completion or to full implementation of an ongoing activity, and recognition of shared research themes across recommendations. These included increased education and training of both researchers and health care professionals, addressing health disparities, fundamental neurobiology research, advanced diagnostics, collaborative biosample repositories, and a focus on developing effective interventions to prevent or treat ADRD by the year 2025 as targeted by the National Plan.
GLOSSARY
- AD=
- Alzheimer disease;
- ADRD=
- Alzheimer disease–related dementias;
- DLB=
- dementia with Lewy bodies;
- FTD=
- frontotemporal degeneration;
- LBD=
- Lewy body dementia;
- NAPA=
- National Alzheimer's Project Act;
- NIA=
- National Institute on Aging;
- NINDS=
- National Institute of Neurological Disorders and Stroke;
- PD=
- Parkinson disease;
- PDD=
- Parkinson disease dementia;
- VaD=
- vascular dementia;
- VCI=
- vascular cognitive impairment
Footnotes
ADRD 2013 Conference Organizing Committee coinvestigators are listed on the Neurology® Web site at Neurology.org.
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Supplemental data at Neurology.org
- Received December 18, 2013.
- Accepted in final form May 20, 2014.
- © 2014 American Academy of Neurology
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