Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

March 17, 2015; 84 (11) ArticleOpen Access

Sleep duration and risk of fatal and nonfatal stroke

A prospective study and meta-analysis

Yue Leng, Francesco P. Cappuccio, Nick W.J. Wainwright, Paul G. Surtees, Robert Luben, Carol Brayne, Kay-Tee Khaw
First published February 25, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001371
Yue Leng
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francesco P. Cappuccio
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nick W.J. Wainwright
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul G. Surtees
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Luben
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carol Brayne
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kay-Tee Khaw
From the Department of Public Health and Primary Care (Y.L., N.W.J.W., P.G.S., R.L., C.B., K.-T.K.), University of Cambridge; and the Division of Mental Health & Wellbeing (F.P.C.), University of Warwick, Coventry, UK.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Sleep duration and risk of fatal and nonfatal stroke
A prospective study and meta-analysis
Yue Leng, Francesco P. Cappuccio, Nick W.J. Wainwright, Paul G. Surtees, Robert Luben, Carol Brayne, Kay-Tee Khaw
Neurology Mar 2015, 84 (11) 1072-1079; DOI: 10.1212/WNL.0000000000001371

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
18195

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Abstract

Objective: To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis.

Methods: The prospective study included 9,692 stroke-free participants aged 42–81 years from the European Prospective Investigation into Cancer–Norfolk cohort. Participants reported sleep duration in 1998–2000 and 2002–2004, and all stroke cases were recorded until March 31, 2009. For the meta-analysis, we searched Ovid Medline, EMBASE, and the Cochrane Library for prospective studies published until May 2014, and pooled effect estimates using a weighted random-effect model.

Results: After 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep was significantly associated with an increased risk of stroke (hazard ratio [HR] = 1.46 [95% confidence interval (CI) 1.08, 1.98]) after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep was smaller (and not statistically significant) (HR = 1.18 [95% CI 0.91, 1.53]). There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep. These were compatible with the pooled HRs from an updated meta-analysis, which were 1.15 (1.07, 1.24) and 1.45 (1.30, 1.62) for short and long sleep duration, respectively.

Conclusions: This prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population.

GLOSSARY

BMI=
body mass index;
CI=
confidence interval;
CVD=
cardiovascular disease;
DBP=
diastolic blood pressure;
HR=
hazard ratio;
ICD-9=
International Classification of Diseases–9;
ICD-10=
International Classification of Diseases–10;
MDD=
major depressive disorder;
MI=
myocardial infarction;
SBP=
systolic blood pressure

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was paid by CRUK and RCUK.

  • Editorial, page 1066

  • Supplemental data at Neurology.org

  • Received July 25, 2014.
  • Accepted in final form October 27, 2014.
  • © 2015 American Academy of Neurology

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

View Full Text

Disputes & Debates: Rapid online correspondence

  • Napping and sleep extension: possible effects over stroke risk in long sleepers
    • Camila Hirotsu, Universidade Federal de Sao Paulomilahirotsu@gmail.com
    • Lenise Jihe Kim, Fernando Morgadinho Coelho, Monica Levy Andersen, Sergio Tufik, Sao Paulo, Brazil
    Submitted March 18, 2015
  • Cause and Effect? REVISED
    • Prasanna N. de Silva, Doctor, Monkwearmouth Hospital, Sunderlandprasanna@mentalhealthsolutions.co.uk
    Submitted March 10, 2015
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Related Articles

  • Is sleep duration a risk factor for stroke?

Topics Discussed

  • All Sleep Disorders
  • All epidemiology
  • All Cerebrovascular disease/Stroke
  • Cohort studies
  • Incidence studies

Alert Me

  • Alert me when eletters are published
Neurology: 99 (6)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise