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March 17, 2015; 84 (11) Article

Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline

Rui Wang, Laura Fratiglioni, Erika J. Laukka, Martin Lövdén, Grégoria Kalpouzos, Lina Keller, Caroline Graff, Alireza Salami, Lars Bäckman, Chengxuan Qiu
First published February 11, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001379
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Article Information

vol. 84 no. 11 1128-1135
DOI: 
https://doi.org/10.1212/WNL.0000000000001379
PubMed: 
25672924
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 18, 2014
  • Accepted in final form November 24, 2014
  • First Published February 11, 2015.

Article Versions

Copyright & Usage: 
© 2015 American Academy of Neurology

Author Disclosures

    1. Rui Wang, MSc,
    2. Laura Fratiglioni, PhD,
    3. Erika J. Laukka, PhD,
    4. Martin Lövdén, PhD,
    5. Grégoria Kalpouzos, PhD,
    6. Lina Keller, PhD,
    7. Caroline Graff, PhD,
    8. Alireza Salami, PhD,
    9. Lars Bäckman, PhD and
    10. Chengxuan Qiu, PhD
  1. Rui Wang, MSc,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Laura Fratiglioni, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Erika J. Laukka, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) the Swedish Research Council, (2)Swedish Research Council for Health, Working Life and Welfare

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Martin Lövdén, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)FORTE, 2013-2277, PI, 2014-2018. (2) Swedish Research Council, 446-2013-7189, PI, 2014-2019,

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Grégoria Kalpouzos, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Lina Keller, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Caroline Graff, PhD,
    8. Scientific Advisory Boards:

    1. 1) (non-profit) Academic research Data Access Committee member for GENFI since 2014

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Invited speaker att Swedish BRain Foundation oktober and november 2014 Invited speaker Swedish Alzheimer foundation 2014

    Editorial Boards:

    1. NONE

    Patents:

    1. Co-inventor in three patents Number and (year): Nr: JP2005- 044776(2005); Nr: JP2010-48067 (2010); Nr EP14158408 (2014)

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Year Funding Agency 2011-2013 Swedish Research Council, no. 21738 research grant

    Research Support, Academic Entities:

    1. Year Funding Agency role 2011-2014 KID PhD-student funding, KI research grant 2006-2011 KID PhD-student funding, KI research grant

    Research Support, Foundations and Societies:

    1. 2015 SCILIFELAB PROJECT FUNDING FOR 100 WHOLE GENOMES OF FAMILIAL EARLY ONSET DEMENTIA CASES, 700K KR 2015-17 CO-APPLICANT IN JPND PREFRONTALS AND CURRENTLY NEGOTIATING FUNDING AMOUNT WITH VR (SWEDISH RESEARCH COUNCIL) (PI JAN VAN SWIETEN, AMSTERDAM) 2015-17 CO-APPLICANT IN JPND DAMNDPATHS AND MY FUNDING AMOUNT FROM VR IS 1379 K KR (PI EVA HEDLUND, STOCKHOLM) 2014 CO-APPLICANT IN JPND WORKING GROUP PRENI TOTAL 50K EUR (PI JONATHAN ROHRER, LONDON) 2006-16 ALF-PROJECT FUNDING (SLL) 5 000K KR 2014 SWEDISH BRAIN FOUNDATION 500K KR 2013-17 CO-APPLICANT IN JPND RHAPSODY AND RECEIVED VR-FUNDING 1 881K KR (PI ALEXANDER KURZ, MUNICH) 2013-16 CO-APPLICANT AGING AND HEALTH SWEDISH RESEARCH COUNCIL 12 144K KR (PI LAURA FRATIGLIONI KI) 2013-14 CO-APPLICANT MAYO CLINIC- KI COLLABORATION GRANT 30K USD (PIS C GRAFF AND KF BIENIEK & D DICKSON) 2010-14 ROCHE POSTDOC FELLOW FUNDING 464K CHF 2013-14 SWEDISH ALZHEIMER FOUNDATION 1 750K KR 2006-14 KI FUNDING FROM STRATNEURO 3075 K SEK & KI- DOCTORAL FUNDING 2 148K KR 2013-15 CORE FACILITY FUNDING FOR BRAIN BANK AT KI 1 500K KR 2012-15 MY SALARY AS MANAGER FOR THE BRAIN BANK AT KI FROM KI STRATNEURO 2012-13 GRANT FOR THE BRAIN BANK AT KI FROM KI STRATNEURO 1500K KR 2005-15 SWEDISH BRAIN POWER 3 556K KR 2011-13 SWEDISH RESEARCH COUNCIL, TOTAL 1 650K KR 2009- 11 MARIANNE AND MARKUS WALLENBERG FOUNDATION FOR CLINICAL RESEARCHERS. 75% SALARY FOR 3 YEARS AND 700K KR PER YEAR IN PROJECT FUNDING. 2010-14 KING GUSTAF V AND QUEEN VICTORIA?S FREE MASONS FOUNDATION: 1 100K KR

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Alireza Salami, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Lars Bäckman, PhD and
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Aging, Neuropsychology, and Cognition

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Swedish Research Council Swedish Council for Working Life and Social Research Swedish Brain Power Alexander von Humboldt Foundation af Jochnick Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Chengxuan Qiu, PhD
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer Disease, Associated Editor, 2010- 2013.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The Swedish Research Council, Project no. K2008-69X-20821-01-3, Years 2008-2012 and K2012-99X-21967-01-3, Years 2012-2015. (3) The Swedish Council for Working Life and Social Research, Grant No. 2007-1172, Years 2008-2012 and 2014-1382, Years 2015-2018.

    Research Support, Academic Entities:

    1. Karolinska Institutet, Stockholm, Sweden

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Aging Research Center (R.W., L.F., E.J.L., M.L., G.K., L.K., A.S., L.B., C.Q.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet–Stockholm University; Stockholm Gerontology Research Center (L.F., L.B.); and Division of Neurogeriatrics (C.G.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Center for Alzheimer Research at Karolinska Institutet, Sweden.
  1. Correspondence to Rui Wang: rui.wang{at}ki.se or Dr. Qiu: chengxuan.qiu{at}ki.se
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