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April 06, 2015; 84 (14 Supplement) April 21, 2015

Preliminary Results of the NINDS/NIBIB Consensus Meeting to Evaluate Pathological Criteria for the Diagnosis of CTE (P2.178)

Ann McKee, Victor Alvarez, Kevin Bieniek, Nigel Cairns, John Crary, Kristen Dams-O'Connor, Rebecca Folkerth, C. Dirk Keene, Irene Litvan, Thomas Montine, Philip Montenigro, Daniel Perl, Thor Stein, William Stewart, Yorghos Tripodis, Jean Paul Vonsattel, Wayne Gordon, Dennis Dickson
First published April 8, 2015,
Ann McKee
6Boston University School of Medicine Boston MA United States
7Boston University School of Medicine Boston MA United States
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Victor Alvarez
8Neurology Boston University School of Medicine Boston MA United States
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Kevin Bieniek
12Department of Pathology Mayo Clinic Jacksonville Jacksonville FL United States
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Nigel Cairns
5Saint Louis MO United States
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John Crary
9Department of Pathology & Cell Biology Columbia University Medical Center New York NY United States
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Kristen Dams-O'Connor
13Mount Sinai School of Medicine New York NY United States
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Rebecca Folkerth
2Boston MA United States
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C. Dirk Keene
10Harborview Medical Center Seattle WA United States
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Irene Litvan
3La Jolla CA United States
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Thomas Montine
1Bellevue WA United States
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Philip Montenigro
2Boston MA United States
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Daniel Perl
15Uniformed Services University of the Health Sciences Bethesda MD United States
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Thor Stein
16Department of Pathology VA Boston Boston MA United States
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William Stewart
14NHS Greater Glasgow and Clyde Glasgow United Kingdom
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Yorghos Tripodis
6Boston University School of Medicine Boston MA United States
7Boston University School of Medicine Boston MA United States
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Jean Paul Vonsattel
4New York NY United States
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Wayne Gordon
13Mount Sinai School of Medicine New York NY United States
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Dennis Dickson
11Mayo Clinic Jacksonville FL United States
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Citation
Preliminary Results of the NINDS/NIBIB Consensus Meeting to Evaluate Pathological Criteria for the Diagnosis of CTE (P2.178)
Ann McKee, Victor Alvarez, Kevin Bieniek, Nigel Cairns, John Crary, Kristen Dams-O'Connor, Rebecca Folkerth, C. Dirk Keene, Irene Litvan, Thomas Montine, Philip Montenigro, Daniel Perl, Thor Stein, William Stewart, Yorghos Tripodis, Jean Paul Vonsattel, Wayne Gordon, Dennis Dickson
Neurology Apr 2015, 84 (14 Supplement) P2.178;

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Abstract

OBJECTIVE: To establish neuropathological consensus criteria for the diagnosis of chronic traumatic encephalopathy (CTE). BACKGROUND: CTE is a neurodegeneration that is associated with repetitive, mild traumatic brain injury. CTE can only be diagnosed with certainty by neuropathological examination of brain tissue. DESIGN/METHODS: Pathological criteria have been proposed for the neuropathological diagnosis of CTE (McKee et al., Brain 2013): 1. Perivascular foci of hyperphosphorylated (p-tau) immunoreactive neurofibrillary tangles (NFTs) and astrocytic tangles (ATs) in the neocortex. 2. Irregular clusters of p-tau immunoreactive NFTs and ATs found preferentially at the sulcal depths. 3. NFTs in the cerebral cortex located primarily in the superficial layers. Supportive, but non-diagnostic, features are 4. Clusters of subpial ATs in the cerebral cortex, most pronounced at the sulcal depths. A group of expert neuropathologists will independently analyze slides from cases of CTE and other tauopathies using the provisional criteria. The neuropathologists will evaluate the cases independently, - first, blinded to the clinical history and gross neuropathological features, and second, after being supplied the additional information. The cases to be evaluated will include, but are not restricted to, CTE, Alzheimer’s disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy and parkinsonism dementia complex of Guam. A single laboratory will process all slides to assure conformity. The reliability of the criteria for the diagnosis of CTE will be determined by measuring group agreement among the neuropathologists using kappa and intra-cluster correlation (ICC) statistics. Sensitivity, specificity and positive predictive values will also be estimated for each rater. RESULTS and CONCLUSIONS: The findings will be discussed at a consensus conference to be held in late February 2015 and the preliminary results of this conference will be presented. Study Supported by: NINDS and NIBIB Cooperative agreement, 1U01NS086659-01 and 1U01NS086625-01.

Disclosure: Dr. McKee has nothing to disclose. Dr. Alvarez has nothing to disclose. Dr. Bieniek has nothing to disclose. Dr. Cairns has nothing to disclose. Dr. Crary has nothing to disclose. Dr. Dams-O'Connor has nothing to disclose. Dr. Folkerth has nothing to disclose. Dr. Keene has nothing to disclose. Dr. Litvan has received personal compensation for activities with Acadia Pharmaceuticals, Pfizer Inc., Teva Neuroscience, Biotie Therapies, and the Michael J. Fox Foundation. Dr. Litvan has received research support from Teva Neuroscience. Dr. Montine has nothing to disclose. Dr. Montenigro has nothing to disclose. Dr. Perl has nothing to disclose. Dr. Stein has nothing to disclose. Dr. Stewart has nothing to disclose. Dr. Tripodis has nothing to disclose. Dr. Vonsattel has nothing to disclose. Dr. Gordon has nothing to disclose. Dr. Dickson has nothing to disclose.

Tuesday, April 21 2015, 7:30 am-12:00 pm

  • Copyright © 2015 by AAN Enterprises, Inc.

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