Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

April 06, 2015; 84 (14 Supplement) April 22, 2015

Intraarterial Thrombolysis And Endovascular Treatment is Safe and Effective In Patients With Ischemic Stroke Due To Dissection (P5.159)

Judd Jensen, Jeffrey Wagner, Kristin Salottolo, David Loy, David Bar-Or
First published April 8, 2015,
Judd Jensen
2Carepoint, P.C. Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey Wagner
1Blue Sky Neurosciences Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristin Salottolo
4Trauma Research Dept Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Loy
3Neurology Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Bar-Or
4Trauma Research Dept Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Intraarterial Thrombolysis And Endovascular Treatment is Safe and Effective In Patients With Ischemic Stroke Due To Dissection (P5.159)
Judd Jensen, Jeffrey Wagner, Kristin Salottolo, David Loy, David Bar-Or
Neurology Apr 2015, 84 (14 Supplement) P5.159;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

OBJECTIVE: To examine the safety and efficacy of intraarterial and endovascular treatment for acute ischemic stroke (AIS) due to dissection. BACKGROUND: Carotid and vertebral artery dissection should not be considered a contraindication for intravenous tPA treatment. Few studies report safety and efficacy of intraarterial thrombolysis or endovascular treatment for dissection. DESIGN/METHODS: We studied consecutive admissions with AIS to our Comprehensive Stroke Center from 2012-2013 who received intraarterial thrombolysis or an endovascular procedure (“aggressive therapy”). We examined differences in adverse events, defined as in-hospital death and symptomatic ICH (sICH), and favorable outcome, defined as Modified Rankin Score (mRS) ≤2 at discharge and 3 months, for AIS patients who presented with mechanism of dissection vs. other cause. RESULTS: Of 1,320 patients with AIS, 173 patients received aggressive therapy and comprise our study population: 15 with dissection (8.7[percnt]: 11 carotid, 4 vertebral) and 158 without dissection (91.3[percnt]). Stroke severity was similar with vs. without dissection (mean NIHSS: 15.4 vs. 17.2, p=0.29). There were no differences in adverse event rates for patients presenting with vs. without dissection (sICH: 0[percnt] vs. 8.2[percnt], p=0.61; mortality: 20.0[percnt] vs. 18.3[percnt], p=1.0). Notably, no AIS patients with dissection receiving aggressive therapy developed a sICH. There were also no differences in favorable outcome for patients presenting with vs. without dissection (discharge mRS ≤2: 26.7[percnt] vs. 20.4[percnt], p=0.52; 3 month mRS ≤2: 58.3[percnt] vs. 45.1[percnt], p=0.38). There were 3 deaths in patients with dissection: one death resulted from occlusion of a stent placed to treat stenosis caused by dissection. CONCLUSIONS: Aggressive therapy, including intraarterial thrombolysis and endovascular treatment, appears to be as safe and effective when used in patients with ischemic stroke due to dissection as in AIS patients with other causes. It would be difficult to create an ethical randomized trial to evaluate aggressive therapy in this patient population.

Disclosure: Dr. Jensen has nothing to disclose. Dr. Wagner has received personal compensation for activities with Genentech, Inc. Dr. Salottolo has nothing to disclose. Dr. Loy has nothing to disclose. Dr. Bar-Or has nothing to disclose.

Wednesday, April 22 2015, 2:00 pm-6:30 pm

  • Copyright © 2015 by AAN Enterprises, Inc.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

Dr. Nicole Sur and Dr. Mausaminben Hathidara

► Watch

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 100 (22)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise