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May 26, 2015; 84 (21) Article

Shared genetic basis for migraine and ischemic stroke

A genome-wide analysis of common variants

Rainer Malik, Tobias Freilinger, Bendik S. Winsvold, Verneri Anttila, Jason Vander Heiden, Matthew Traylor, Boukje de Vries, Elizabeth G. Holliday, Gisela M. Terwindt, Jonathan Sturm, Joshua C. Bis, Jemma C. Hopewell, Michel D. Ferrari, Kristiina Rannikmae, Maija Wessman, Mikko Kallela, Christian Kubisch, Myriam Fornage, James F. Meschia, Terho Lehtimäki, Cathie Sudlow, Robert Clarke, Daniel I. Chasman, Braxton D. Mitchell, Jane Maguire, Jaakko Kaprio, Martin Farrall, Olli T. Raitakari, Tobias Kurth, M. Arfan Ikram, Alex P. Reiner, W.T. Longstreth, Peter M. Rothwell, David P. Strachan, Pankaj Sharma, Sudha Seshadri, Lydia Quaye, Lynn Cherkas, Markus Schürks, Jonathan Rosand, Lannie Ligthart, Giorgio B. Boncoraglio, George Davey Smith, Cornelia M. van Duijn, Kari Stefansson, Bradford B. Worrall, Dale R. Nyholt, Hugh S. Markus, Arn M.J.M. van den Maagdenberg, Chris Cotsapas, John A. Zwart, Aarno Palotie, For the International Headache Genetics Consortium, Martin Dichgans, For the METASTROKE Collaboration of the International Stroke Genetics Consortium
First published May 1, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001606
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Article Information

vol. 84 no. 21 2132-2145
DOI: 
https://doi.org/10.1212/WNL.0000000000001606
PubMed: 
25934857
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 5, 2014
  • Accepted in final form January 21, 2015
  • First Published May 1, 2015.

Article Versions

Copyright & Usage: 
© 2015 American Academy of Neurology

Author Disclosures

    1. Rainer Malik, PhD,
    2. Tobias Freilinger, MD,
    3. Bendik S. Winsvold, PhD,
    4. Verneri Anttila, PhD,
    5. Jason Vander Heiden, MSc,
    6. Matthew Traylor, PhD,
    7. Boukje de Vries, PhD,
    8. Elizabeth G. Holliday, PhD,
    9. Gisela M. Terwindt, MD, PhD,
    10. Jonathan Sturm, PhD,
    11. Joshua C. Bis, PhD,
    12. Jemma C. Hopewell, PhD,
    13. Michel D. Ferrari, MD, PhD,
    14. Kristiina Rannikmae, MD,
    15. Maija Wessman, PhD,
    16. Mikko Kallela, MD, PhD,
    17. Christian Kubisch, MD,
    18. Myriam Fornage, PhD,
    19. James F. Meschia, MD,
    20. Terho Lehtimäki, MD,
    21. Cathie Sudlow, FRCP,
    22. Robert Clarke, FRCP,
    23. Daniel I. Chasman, PhD,
    24. Braxton D. Mitchell, PhD,
    25. Jane Maguire, PhD,
    26. Jaakko Kaprio, MD, PhD,
    27. Martin Farrall, FRCPath,
    28. Olli T. Raitakari, MD, PhD,
    29. Tobias Kurth, MD, ScD,
    30. M. Arfan Ikram, MD,
    31. Alex P. Reiner, PhD,
    32. W.T. Longstreth Jr., MD,
    33. Peter M. Rothwell, FMedSci,
    34. David P. Strachan, MD,
    35. Pankaj Sharma, PhD,
    36. Sudha Seshadri, MD,
    37. Lydia Quaye, PhD,
    38. Lynn Cherkas, PhD,
    39. Markus Schürks, MD, MSc,
    40. Jonathan Rosand, MD,
    41. Lannie Ligthart, PhD,
    42. Giorgio B. Boncoraglio, MD,
    43. George Davey Smith, DSc,
    44. Cornelia M. van Duijn, PhD,
    45. Kari Stefansson, MD, PhD,
    46. Bradford B. Worrall, MD, MSc,
    47. Dale R. Nyholt, PhD,
    48. Hugh S. Markus, FRCP,
    49. Arn M.J.M. van den Maagdenberg, PhD,
    50. Chris Cotsapas, PhD,
    51. John A. Zwart, MD, PhD,
    52. Aarno Palotie, MD;
    53. For the International Headache Genetics Consortium,
    54. Martin Dichgans, MD;
    55. For the METASTROKE Collaboration of the International Stroke Genetics Consortium
  1. Rainer Malik, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Tobias Freilinger, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Speaker honoraria from Boehringer Ingelheim (2) Speaker honoraria from Allergan

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Deutsche Forschungsgemeinschaft (DFG), grant number FR3324/2-1, PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Bendik S. Winsvold, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) The Research Council of Norway, grant no. 231187/F20, (2) the South-Eastern Norway Regional Health Authority (grant number 2010075 and 2011083.

    Research Support, Academic Entities:

    1. Forsbergs og Aulies legat.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Verneri Anttila, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Orion Farmos Research Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Jason Vander Heiden, MSc,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Travel funding from New England Biolabs to speak regarding immunoglobulin repertoire sequencing at the 2014 American Society of Human Genetics annual meeting.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Library of Medicine, T15 LM07056, 2012-2015.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Matthew Traylor, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Boukje de Vries, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Elizabeth G. Holliday, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Australian National Health and Medical Research Council (NHMRC), APPID 631096, Chief Investigator, 2010-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Gisela M. Terwindt, MD, PhD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Menarini: Funding for conference visit

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Supported by grants of the Netherlands Organisation for Scientific Research (NWO) (GMT Vidi 917-11-319), and FP7-EUROHEADPAIN-no.602633

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Jonathan Sturm, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NHMRC. Project grant no. 569257, investigator, 2009

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Australian Brain Foundation Research Grant, investigator, 2008 National Stroke Foundation Research Grant, investigator 2008

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Joshua C. Bis, PhD,
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Jemma C. Hopewell, PhD,
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Research grants paid to my institution from pharmaceutical companies (Merck, Abbott (Solvay), AstraZeneca, Bayer Germany, Bayer US, GlaxoSmithKline, Merck & Schering) for studies conducted, analysed and reported independently of all funding sources. The CTSU has a policy of not accepting honoraria or other payments, except for reimbursement of costs to participate in scientific meetings.

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) British Heart Foundation (FS/14/55/30806) (2) British Heart Foundation, Centre for Research Excellence, Oxford

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  13. Michel D. Ferrari, MD, PhD,
    14. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Cephalalgia, associate editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Medtronic

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Netherlands Organization for Scientific Research (NWO) (2) European Community (3) ZonMW

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Dutch Heart Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  14. Kristiina Rannikmae, MD,
    15. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Edinburgh and Lothians Health Foundation REMIND Fund and Stroke Research and Amenities Endowments Fund

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  15. Maija Wessman, PhD,
    16. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Folkh?lsan Research Foundation, Academy of Finland (grant no 139795), Medicinska Underst?dsf?reningen Liv och H?lsa

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  16. Mikko Kallela, MD, PhD,
    17. Scientific Advisory Boards:

    1. Advisory Board for MSD (terminated in 2011), Advisory Board for Allergan (terminated in 2013)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. MSD, a scientific meeting, 2009, 2010, 2011 Allergan, a scientific meeting 2011

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. MSD speaker 2008, 2009, 2010, 2011, 2014 Pfizer speaker 2008, 2009, 2010, 2011 Menarini speaker 2008, 2009, 2010, 2011 Boehringer-Ingelheim speaker 2008, 2009 Bayer speaker 2010 Allergan speaker 2013 Novartis speaker 2013, 2014 Teva speaker 2013, Genzyme speaker 2014 AGA speaker 2012

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Helsinki University Central Hospital, funded for research, 2008, 2009, 2010, 2011, 2012, 2013, 2014

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Helsinki Headache Center, hold stock, 2008, 2009, 2010, 2011, 2012, 2013, 2014

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  17. Christian Kubisch, MD,
    18. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) German Research Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  18. Myriam Fornage, PhD,
    19. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  19. James F. Meschia, MD,
    20. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. On the editorial boards of Mayo Clinic Proceedings, Stroke, and the European Journal of Neurology.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  20. Terho Lehtimäki, MD,
    21. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  21. Cathie Sudlow, FRCP,
    22. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) UK MRC, UK Biobank programme renewal, ?35 million, 2010-2017 (co-applicant) (2) UK MRC, Dementias Platform UK programme grant, ?12 million, 2014-2019 (co-applicant)

    Research Support, Academic Entities:

    1. (1) British Heart Foundation 2012-2017 RESTART trial of antiplatelet treatment in ICH ( co- applicant) (2) UKBiobank 01/05/2012-ongoing Stroke Outcomes Pilot (principal applicant) (3) UK Biobank 01/09/2012-ongoing chief scientist support (principal applicant) (4) NIH via University of Maryland Stroke GWAS sub award for stroke phenotyping 01/06/2011-31/12/2013

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  22. Robert Clarke, FRCP,
    23. Scientific Advisory Boards:

    1. It is CTSU policy to decline personal compensation from any source. While I am a member of several Scientific Advisory Boards (CARDIOGRAMplusC4D, METASTROKE, BEST-D), I have not received any payments for these roles.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. PlosONE (no payment)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. 1)BHF (2012-2014) Vitamin D supplementation and markers of inflammation, immunity and arterial stiffness R Clarke, J Armitage, J Knight, J Tomson ?112K 2) BHF (2009-2017) Research Excellence Award R Collins, H Watkins*, Z Chen, R Clarke, SC Darby?8.4M shared; 3) BHF (2008-2013)Direct support for trials and epidemiological studies.R Collins, R Clarke, L Bowman, M Landray ?2.6M; 4) BHF (2012-2014);Effect of vitamin D on cardiac contractile function R Clarke, J Tomson, J Armitage ?40k MRC (2008-2013) Direct support for large epidemiological studies and collaborative overviews R Collins, R Peto, C Baigent, J Armitage, Z Chen, R Clarke ?13.8M; 5) MRC (2013-2016) Genomic and metabolomic analysis of haemorrhagic stroke in the China Kadoorie Biobank Z Chen, M Ala-Korpela*, R Clarke, Rory Collins, P Donnelly*, M Hill, L Li*, I Millwood, R Peto, C Sudlow*, R Walters ?1.3M.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  23. Daniel I. Chasman, PhD,
    24. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate editor for Arteriosclerosis, Thrombosis, and Vascular Biology 2009-. No compensation.

    Patents:

    1. NONE

    Publishing Royalties:

    1. Protein Stucture: Determination, Analysis, and Applications for Drug Discovery. (2003) Chasman ed. Marcel Dekker. New York.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  24. Braxton D. Mitchell, PhD,
    25. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Diabetes, Associate Editor, 2009 - Diabetes/Metabolism Research and Reviews (Co-Editor, 2002-2014) Diabetes Management (Editorial Advisory board, 2011-2014)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. P60DK079637-02 (Wondisford) 03/05/13 ? 01/31/18 0.60 calendar NIH $250,000 (Johns Hopkins subcontract) Diabetes Research and Training Center In collaboration with Johns Hopkins University, the University of Maryland will develop a Baltimore Diabetes Research and Treatment Center to provide rational interventions for the effective treatment and prevention of diabetes and related diseases. P30 DK072488-06 (Shuldiner) 09/15/05 - 08/31/15 0.90 calendar NIH $807,956 Mid-Atlantic Nutrition Obesity Research Center The NORC will focus on the influence of nutrition and exercise on risk for age-related chronic diseases, including obesity, type 2 diabetes, hypertension, cardiovascular disease (CVD), sleep disordered breathing, and osteoporosis. U01HL105198-06 (Shuldiner) 04/10/10 ? 03/31/15 1.80 calendar NIH $1,941,032 Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study The major goal of this randomized clinical trial is to provide evidence base for translation of genotype-directed anti-platelet therapy into clinical practice. U01NS069208 (Kittner) 07/01/10 - 06/30/14 2.40 calendar NIH $449,701 The NINDS Ischemic Stroke Genetics Consortium The major goal of this project is to establish a consortium to perform a large sample size genome-wide association study for ischemic stroke using both previously genotyped and samples that need genotyping and to replicate and extend findings from discovery sample through international collaboration with other genome-wide association studies. R01MH085646-01 (Hong) 07/01/10 ? 05/31/201 0.60 calendar NIH $377,779 Neural Oscillatory Biomarkers for Genetics and Animal Model Schizophrenia This application proposes to critically examine the relevance of neural oscillatory response in the genetics of schizophrenia and test the overall hypothesis that neural oscillatory signals may serve as key biomarkers for the genetics and translational studies for schizophrenia R01DK088231-01 (Gerhard) 12/01/10 ? 11/30/15 0.50 calendar NIH $120,586 (sub with Geisinger Clinic) Genetic Determinants of Weight Loss and Resolution of Co-Morbidities The goal of this project is to identify common and rare gene variants that are associated with weight loss and improvement in metabolic traits following bariatric surgery. R01 AR052873-07 (Abramson) 07/01/12-06/30/17 0.60 calendar NIH $40,565 (UMD subcontract) Leukocyte Gene Expression and Genetic Biomarkers of OA Incidence and Progression This project seeks to identify inflammation-related genetic, proteomic, and lipidomic biomarkers that predict progression of osteoarthritis in symptomatic patients. MITCHELL, Braxton D. (active continued) R01 EB015611-01 (Kochunov) 08/01/12 ? 07/31/15 0.60 calendar NIH $859,322 SOLAR-Eclipse Computational Tools for Imaging Genetics The goal of this study is to develop tools and computational methods for integrating and analyzing multidimensional imaging data in genetic studies. P30 NR014129-01 (Dorsey) 09/27/12 ? 08/31/17 0.60 calendar NIH $45,284 (Genomics Core only) Center for Genomics of Pain This center provides support for investigators at the University of Maryland seeking to use genomic approaches to understand the etiology and treatment of pain. R01 NS073346 (Shuldiner) 03/15/11 ? 02/28/14 0.90 calendar NIH $94,309 (UMD subcontract) Secondary Prevention of Subcortical Stroke Prevention Genetic Substudy Timing The goal of this project is to identify genetic determinants of recurrent stroke, including those mediated by response to clopidogrel and other antiplatelet agents. No number (Puett, Mitchell, Co-PIs) 08/01/13-07/31/14 0 calendar Univ Maryland Research and Innovation Seed Program $70,660 Ambient Air pollution and Metabolic Syndrome in the Lancaster County Amish This project will develop preliminary data on the relationship of air pollution exposures, using state of the art spatio-temporal statistical models, and their relationship to metabolic and cardiovascular health in this unique population of Old Order Amish. R01 HL121007-01 (Mitchell) 01/15/14-11/30/17 1.56 calendar NIH $276,108 Identification and Functional Characterization of a Gene Influencing LDL-C on 5q

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  25. Jane Maguire, PhD,
    26. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  26. Jaakko Kaprio, MD, PhD,
    27. Scientific Advisory Boards:

    1. D-tect project, PI professor Berit Heitmann, Copenhagen University, non-profit

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1) Pfizer Ltd, speaker honorarium 2012

    Editorial Boards:

    1. Addiction, associate editor, 2008 - > Nicotine and Tobacco Research, associate editor, 2010 - > Twin Research and Human Genetics, editorial board member, 2003 -> Finnish Journal of Social Medicine 2000-> Psychiatric Genetics, editorial board member 2000->

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Pfizer Ltd, Pharmacogenetics of smoking cessation, 2011-2014

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1.  Addiction program (#118555, PI) 2007-2010 Academy of Finland, Centre of Excellence in Complex Disease Genetics, J.Kaprio group 2006-2011 Academy of Finland Finnish Distinguished Professor programme, co-host for Professor Joe Terwilliger (Columbia University) 2006-2010 Academy of Finland Finnish Distinguished Professor programme, host for Professor Juni Palmgren (Karolinska Institute) 2011-2015 Academy of Finland. Genes and environmental predictors of tobacco addiction in adolescents and young adults (PI). Consortium partner Olli Raitakari, University of Turku. Co-funded with CIHR (PI Rachel Tyndale, University of Toronto) . Funded through the SKIDI-Kids Research program. 2011-2014 European Union funding EC FP6. DiOGenes. Diet, Obesity and Genes. FP6-513946. J.Kaprio PI for University of Helsinki, http://www.diogenes-eu.org/ 2005-2009 EC FP7. TORNADO. Molecular Targets Open for Regulation by the gut flora ? New Avenues for improved Diet to Optimize European health. KBBE-2007-2-2-07/222720-2 (JK PI for University of Helsinki partner, WP leader) Integrating project http://www.fp7tornado.eu/ 2009-2013 EC FP7. ENGAGE Consortium European Network for Genetic and Genomic Epidemiology. (HEALTH-F4-2007-201413). (JK PI University of Helsinki, University of Helsinki coordinator partner, JK WP leader). http://www.euengage.org/ Integrating project 2008-2012 EC FP7. GENODISC (Disc-degeneration linked pathologies: novel biomarkers and diagnostics for targeting treatment and repair). HEALTH-F2-2008-201626. 1.3.08-28.2.13. J.Kaprio PI for Helsinki partner and WP leader. (http://www.physiol.ox.ac.uk/genodisc/index.html) 2008-2013 EC FP7 I.Family. Determinants of eating behaviour in European children, adolescents and their parents-KBBE-2010-4. 2012-2017. J. Kaprio PI for University of Helsinki partner. 2012-2017 US NIH funding U.S. -P.H.S. (# DA-12584, yrs 6-10). Nicotine addiction genetics. Co-PI J.Kaprio. Finnish subcontract 2008-2012 U.S. -P.H.S. (# AA-12502) FinnTwin12 studies of alcohol use. Co-PI J.Kaprio. Finnish subcontract 2005-2010 U.S. -P.H.S. (# AA-15416, PI DM Dick) Gene-environment interactions in adolescent alcohol use. J.Kaprio Co-Investigator, 2005-2010 U.S.-P.H.S. (#AA-15416, PI DM Dick, Virginia Commonwealth University), supplemental award for genotyping 2009-2011 U.S.-P-H.S (# HL104125, Xiaoling Wang, Medical College of Georgia. A genome-wide methylation study on essential hypertension. (local PI J Kaprio) 2011-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  27. Martin Farrall, FRCPath,
    28. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) HEFCE, UK (block grant to University)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Wellcome Trust (2) British Heart Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  28. Olli T. Raitakari, MD, PhD,
    29. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  29. Tobias Kurth, MD, ScD,
    30. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) BMJ, consulting clinical epidemiology editor, since 2010. (2) Cephalalgia, associate editor, since 2010.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I have received within the last 2 years investigator- initiated research funding from the French National Research Agency and the US National Institutes of Health.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  30. M. Arfan Ikram, MD,
    31. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Kaizo ltd, speaker honorarium

    Editorial Boards:

    1. (1) Neuroepidemiology, Editorial Board Member, 2011-2015, (2) PLoS One, Academic Editor, 2013-2015, (3) Journal of Alzheimer Disease, Academic Editor, 2015

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Janssen Prevention Center

    Research Support, Government Entities:

    1. (1) Netherlands Organization for Health Research and Development (ZonMW: 916.13.054)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) the Netherlands Heart Foundation (2009B102 and 2012T008), (2) Internationaal Parkinson Fonds, (3) Internationale Stichting Alzheimer Onderzoek (#12533), (4) Alzheimer Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  31. Alex P. Reiner, PhD,
    32. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  32. W.T. Longstreth Jr., MD,
    33. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Dr. Longstreth is a co-investigator on several NIH-funded studies.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  33. Peter M. Rothwell, FMedSci,
    34. Scientific Advisory Boards:

    1. Bayer - Executive Committee of ARRIVE Trial - 2006 onwards Servier - Executive Committee of PERFORM trial - 2005 -2010 Pfizer - IDMC if Rocket-AF Trial - 2006 - 2009 Biotronic - Executive Committee of device trial - 2005 - 2011

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. I don't keep a record. Certainly had travel expenses paid by Sanofi-Aventis, Servier, Astra-Zeneca and Bayer in past. However, nothing relevant to this manuscript.

    Editorial Boards:

    1. Editorial Board - Lancet Neurology, Stroke, Cerebrovascular Diseases Assistant editor - International Journal of Stroke

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  34. David P. Strachan, MD,
    35. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) UK government (HEFCE core grant to St George's, University of London, which pays my salary) 1990-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  35. Pankaj Sharma, PhD,
    36. Scientific Advisory Boards:

    1. Bohringer 2009 & 2013 advisory board member 2013-14 Bayer advisory board member

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. J Royal Soc Medicine Cardiovascular Disease Editor in Chief

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  36. Sudha Seshadri, MD,
    37. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer's Disease, Associate Editor since 2005. Stroke: Editorial Board since 2010. Neurology: Editorial Board since 2011.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NIA: Grant number: R01 AG08122 (PI: Seshadri, Wolf); role: PI (Multiple PI grant) 08/01/10-07/31/16; NIH/NINDS: Grant number R01 NS017950 (Wolf); role: investigator; 07/01/09-6/31/14; NIH/NIA: 1 R01 AG033040-01 (PI: Wolf); role: investigator; 01/15/09-12/31/13; NIH/NIA: Grant number: R01 AG033193(PI: Seshadri); 02/01/09-01/31/17 NIH/NIA: Grant Number: U01 AG49505 (PI: Seshadri) 08/01/14-08/01/18

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  37. Lydia Quaye, PhD,
    38. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  38. Lynn Cherkas, PhD,
    39. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  39. Markus Schürks, MD, MSc,
    40. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) The Journal of Headache and Pain, Advisory Board member, since 2010, (2) BMC Neurology, Associate Editor, since 2011.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Bayer HealthCare Pharmaceuticals, full-time employee, since 2011.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. (1) Bayer, 2014

    Legal Proceedings:

    1. NONE

  40. Jonathan Rosand, MD,
    41. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Lancet Neurology, editorial board member Stroke, editorial board member

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Boehringer Ingelheim

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS, R01NS059727 NINDS, R01NS073344 NINDS, U01NS069208 NINDS, U01NS069763

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Boehringer Ingelheim, consultant

  41. Lannie Ligthart, PhD,
    42. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. EFIC-Gr?nenthal Grant

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  42. Giorgio B. Boncoraglio, MD,
    43. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  43. George Davey Smith, DSc,
    44. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  44. Cornelia M. van Duijn, PhD,
    45. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  45. Kari Stefansson, MD, PhD,
    46. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I am an employee of deCODE genetics

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. The study was funded in part by deCODE genetics

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  46. Bradford B. Worrall, MD, MSc,
    47. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology: Associate Editor 1 July 2009 - present Seminars in Neurology Editorial Board 2006-2014

    Patents:

    1. NONE

    Publishing Royalties:

    1. Chapter Author for Merritt's Neurology editions 10, 11, and 12.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS/NIH U-01 (RFA-NS-09-002) The NINDS International Stroke Genetics Consortium Study; Co-Principal Investigator, co-Chair of Phenotyping core; 3/31/10- 8/31/15 NHGRI/NIH U-01 HG005160 Pharmocogenomic studies in VISP: results and implications for clinical trial design - Part of the Genomics and Randomized Trials Network (GARNET); Co-Principal Investigator, Co-chair phenotype harmonization subcommittee, Chair incidental findings subcommittee, Member of Steering and Publications committees; 9/09-1/31/14 NINDS/NIH U01 NS NS069763 The Ethic/ Racial varieation in IntraCerebral Hemorrhage (ERICH) study - Daniel Woo PI. Site Investigator NHLBI (contract no grant #) Cardiovascular Substudy to Age-Related Eye Disease Study 2 (AREDS2); Principal Investigator, cerebrovascular outcomes adjudicator; 01/01/09- 12/31/12 NINDS - R25 NS065733 NINDS Research Education program for Residents and Fellows at the University of VA; Mentor; March 2009- February 2014 NINDS/NIH- R01 NS42147 Discovery for Warfarin-Related Intracerebral Hemorrhage (GOCHA); Site PI; 12/04-8/14 NINDS/NIH- R01 NS039512 Familial Intracranial Aneurysm Study (FIA) ; Executive committee member, site co-investigator; 2/1/99-8/31/13

    Research Support, Academic Entities:

    1. University of Virginia - CENETERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Prinicpal Investigator 10/13-9/15

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  47. Dale R. Nyholt, PhD,
    48. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  48. Hugh S. Markus, FRCP,
    49. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Section editor International Journal of stroke editorial board Clin Neurology and Neurosurgery and BMC Medcine

    Patents:

    1. NONE

    Publishing Royalties:

    1. Stroke Medicine OUP. 2010

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Wellcome trsut fro WTCCC2

    Research Support, Academic Entities:

    1. Stroke Association, EU, Wellcome Trust, The British Heart Foundation, Alzheimer Research for peer reviewed research grants

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  49. Arn M.J.M. van den Maagdenberg, PhD,
    50. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  50. Chris Cotsapas, PhD,
    51. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. PLoS Genetics, associate editor, 2012-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Biogen-Idec

    Research Support, Government Entities:

    1. NINDS, R01 NS049477, analyst, 2011-2015 NIAID, U01 AI089859, site PI, 2012-2014 NIAID, U19 AI056363, site PI, 2011-2013

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. RE Children's Consortium

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  51. John A. Zwart, MD, PhD,
    52. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  52. Aarno Palotie, MD;
    53. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Received travel expenses and/or honoraria for lectures or educational activities not funded by industry

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Finnish Academy, European Union NIH, NINDS,

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Juselius Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  53. For the International Headache Genetics Consortium,
  54. Martin Dichgans, MD;
    55. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Bayer Vital, travel expenses and honoraria for lectures, (2) Boehringer Ingelheim Pharma, travel expenses and honoraria for lectures, (3) Heel, travel expenses and honoraria for lectures, (4) Bristol-Meyer Squibb, travel expenses and honoraria for lectures, (5) Lundeck, travel expenses and honoraria for lectures, (6) Sanofi- Aventis, travel expenses and honoraria for lectures, (7) Shire, travel expenses and honoraria for lectures, (8) German Research Foundation (DFG), research support, (9) Vascular Dementia Research Foundation, research support, (10) Corona Foundation, research support, (11) Jackst?dt Foundation, research support.

    Editorial Boards:

    1. (1) Stroke the International Journal of Stroke, editor, (2) Cerebrovascular diseases, editorial board member, (3) Journal of Neurochemistry, editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Bayer Vital, (2) Boehringer Ingelheim, (3) Bristol- Meyer Squibb, (4) Heel

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Wellcometrust, 03/08 following, (2) European Union (EU FP 7), investigator, 10/13-09/16, (3) German Federal Ministry of Education and Research (BMBF), investigator, 12/13-11/16, (4) European Union (EU FP 6), investigator, 03/12-02/15

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Vascular Dementia Research Foundation, (2) Corona Foundation, (3) Jackst?dt Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  55. For the METASTROKE Collaboration of the International Stroke Genetics Consortium
  1. Author affiliations are provided at the end of the article.
  1. Correspondence to Dr. Dichgans: martin.dichgans{at}med.uni-muenchen.de
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