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June 16, 2015; 84 (24) Clinical/Scientific Notes

Immunotherapy of oneiric stupor in Morvan syndrome: Efficacy documented by actigraphy

Simone Baiardi, Federica Provini, Patrizia Avoni, Marco Pasquinelli, Rocco Liguori
First published May 15, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001694
Simone Baiardi
From the University of Bologna (S.B., F.P., P.A., R.L.); IRCCS (F.P., P.A., R.L.), Institute of Neurological Sciences of Bologna; and Infermi Hospital (M.P.), Rimini, Italy.
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Federica Provini
From the University of Bologna (S.B., F.P., P.A., R.L.); IRCCS (F.P., P.A., R.L.), Institute of Neurological Sciences of Bologna; and Infermi Hospital (M.P.), Rimini, Italy.
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Patrizia Avoni
From the University of Bologna (S.B., F.P., P.A., R.L.); IRCCS (F.P., P.A., R.L.), Institute of Neurological Sciences of Bologna; and Infermi Hospital (M.P.), Rimini, Italy.
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Marco Pasquinelli
From the University of Bologna (S.B., F.P., P.A., R.L.); IRCCS (F.P., P.A., R.L.), Institute of Neurological Sciences of Bologna; and Infermi Hospital (M.P.), Rimini, Italy.
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Rocco Liguori
From the University of Bologna (S.B., F.P., P.A., R.L.); IRCCS (F.P., P.A., R.L.), Institute of Neurological Sciences of Bologna; and Infermi Hospital (M.P.), Rimini, Italy.
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Citation
Immunotherapy of oneiric stupor in Morvan syndrome: Efficacy documented by actigraphy
Simone Baiardi, Federica Provini, Patrizia Avoni, Marco Pasquinelli, Rocco Liguori
Neurology Jun 2015, 84 (24) 2457-2459; DOI: 10.1212/WNL.0000000000001694

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Morvan syndrome (MoS) is a rare acquired channelopathy associated with autoantibodies against potassium channel complex and clinically characterized by the heterogeneous combination of neuromyotonia, dysautonomia, and encephalopathy.1 Peculiar CNS symptoms are organic insomnia, which ranges from mild to malignant forms characterized by complete loss of sleep, and persistent motor/autonomic hyperactivation (agrypnia excitata2). We describe a patient with MoS who developed progressive agrypnia excitata, in which IV immunoglobulin (IVIg) treatment induced a progressive recovery of the physiologic sleep-wake cycle, documented by videopolysomnography (VPSG) and actigraphic monitoring.

Acknowledgments

Acknowledgment: The authors thank the patient, Francesco Mignani for help in preparing the figures, Elena Zoni for help in preparing the videos, and Cecilia Baroncini for English revision.

Footnotes

  • ↵* All authors contributed equally to this work.

  • Supplemental data at Neurology.org

  • Author contributions: Dr. Baiardi: data collection, interpretation of results, preparation of the manuscript. Dr. Provini: data collection, interpretation of results, preparation of the manuscript. Dr. Avoni: data collection, interpretation of results. Dr. Pasquinelli: data collection, interpretation of results. Prof. Liguori: data collection, interpretation of results, preparation of the manuscript.

  • Study funding: No targeted funding reported.

  • Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

  • Received December 17, 2014.
  • Accepted in final form March 6, 2015.
  • © 2015 American Academy of Neurology
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