Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

January 27, 2015; 84 (4) Article

Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population

Alberto R. Ramos, Wassim Tarraf, Tatjana Rundek, Susan Redline, William K. Wohlgemuth, Jose S. Loredo, Ralph L. Sacco, David J. Lee, Raanan Arens, Patricia Lazalde, James P. Choca, Thomas Mosley, Hector M. González
First published December 24, 2014, DOI: https://doi.org/10.1212/WNL.0000000000001181
Alberto R. Ramos
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wassim Tarraf
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatjana Rundek
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan Redline
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William K. Wohlgemuth
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jose S. Loredo
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph L. Sacco
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David J. Lee
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raanan Arens
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patricia Lazalde
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James P. Choca
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Mosley Jr
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hector M. González
From the Departments of Neurology (A.R.R., T.R., R.L.S.) and Epidemiology and Public Health (T.R., R.L.S., D.J.L.), University of Miami, Miller School of Medicine, FL; Institute of Gerontology (W.T.), Wayne State University, Detroit, MI; Brigham and Women's Hospital and Beth Israel Deaconess Medical Center (S.R.), Harvard Medical School, Boston, MA; Bruce W. Carter Department of Veterans Affairs Medical Center (W.K.W.), Miami, FL; Department of Medicine (J.S.L.), University of California San Diego; The Children's Hospital at Montefiore (R.A.), Albert Einstein College of Medicine, Bronx, NY; HCHS/SOL Field Center (P.L.), San Diego State University, CA; Department of Psychology (J.P.C.), Roosevelt University, Chicago, IL; Department of Neurology (T.M.), University of Mississippi, Jackson; and Department of Epidemiology and Biostatistics (H.M.G.), Michigan State University, East Lansing.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Obstructive sleep apnea and neurocognitive function in a Hispanic/Latino population
Alberto R. Ramos, Wassim Tarraf, Tatjana Rundek, Susan Redline, William K. Wohlgemuth, Jose S. Loredo, Ralph L. Sacco, David J. Lee, Raanan Arens, Patricia Lazalde, James P. Choca, Thomas Mosley, Hector M. González
Neurology Jan 2015, 84 (4) 391-398; DOI: 10.1212/WNL.0000000000001181

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
413

Share

  • Article
  • Figures & Data
  • Info & Disclosures
  • CME Course
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: We evaluated the association between obstructive sleep apnea (OSA) and neurocognitive function among community-dwelling Hispanic/Latino individuals in the United States.

Methods: Cross-sectional analysis of the Hispanic Community Health Study/Study of Latinos middle-aged and older adults, aged 45 to 74 years, with neurocognitive test scores at baseline measurements from 2008 to 2011. Neurocognitive scores were measured using the Word Fluency (WF) Test, the Brief–Spanish English Verbal Learning Test (SEVLT), and the Digit Symbol Substitution (DSS) Test. OSA was defined by the apnea-hypopnea index (AHI). Multivariable linear regression models were fit to evaluate relations between OSA and neurocognitive scores.

Results: The analysis consisted of 8,059 participants, mean age of 56 years, 55% women, and 41% with less than high school education. The mean AHI was 9.0 (range 0–142; normal AHI <5/h). There was an association between the AHI and all 4 neurocognitive test scores: Brief-SEVLT–sum (β = −0.022) and –recall (β = −0.010), WF (β = −0.023), and DSS (β = −0.050) at p < 0.01 that was fully attenuated by age. In the fully adjusted regression model, female sex was a moderating factor between the AHI and WF (β = −0.027, p < 0.10), SVELT-sum (β = −0.37), SVELT-recall (β = −0.010), and DSS (β = −0.061) at p < 0.01.

Conclusion: OSA was associated with worse neurocognitive function in a representative sample of Hispanic/Latino women in the United States.

GLOSSARY

AHI=
apnea-hypopnea index;
ARES=
Apnea Risk Evaluation System;
BMI=
body mass index;
CI=
confidence interval;
DSS=
Digit Symbol Substitution;
DTI=
diffusion tensor imaging;
HCHS/SOL=
Hispanic Community Health Study/Study of Latinos;
OSA=
obstructive sleep apnea;
SEVLT=
Spanish English Verbal Learning Test;
WF=
Word Fluency

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received April 25, 2014.
  • Accepted in final form September 29, 2014.
  • © 2014 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
  • CME Course

More Online

CME Course

Topics Discussed

  • All Cognitive Disorders/Dementia
  • Cohort studies
  • Sleep apnea
  • Risk factors in epidemiology

Alert Me

  • Alert me when eletters are published
Neurology: 98 (24)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise