Valproate and pregnancyAbout pregnancy and epilepsy
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In their article “IQ at 6 years after in utero exposure to antiepileptic drugs: A controlled cohort study,” Dr. Baker and colleagues1 studied the long-term cognitive effects in children whose mothers took antiseizure medications while pregnant. They studied 243 pregnant women with epilepsy and 287 pregnant women without epilepsy (also known as “controls”) for comparison. They performed IQ testing on both groups of children at age 6. They chose this age because it is a good predictor of thinking and learning later in life. Children of women with epilepsy were grouped based on which antiepileptic medications they were exposed to in utero.
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