Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
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Article Information
- Received June 24, 2014
- Accepted in final form November 12, 2014
- First Published February 4, 2015.
Article Versions
- Previous version (February 4, 2015 - 13:01).
- You are viewing the most recent version of this article.
Author Disclosures
- Kristiina Rannikmäe, MD,
- Gail Davies, PhD,
- Pippa A. Thomson, PhD,
- Steve Bevan, BSc, PhD,
- William J. Devan, BSc,
- Guido J. Falcone, MD, ScD, MPH,
- Matthew Traylor, MSc,
- Christopher D. Anderson, MD, MMSc,
- Thomas W.K. Battey, BS,
- Farid Radmanesh, MD, MPH,
- Ranjan Deka, PhD,
- Jessica G. Woo, PhD,
- Lisa J. Martin, MD,
- Jordi Jimenez-Conde, MD, PhD,
- Magdy Selim, MD, PhD,
- Devin L. Brown, MD, MS,
- Scott L. Silliman, MD,
- Chelsea S. Kidwell, MD,
- Joan Montaner, MD, PhD,
- Carl D. Langefeld, PhD,
- Agnieszka Slowik, MD,
- Björn M. Hansen, MD,
- Arne G. Lindgren, MD, PhD,
- James F. Meschia, MD,
- Myriam Fornage, PhD,
- Joshua C. Bis, PhD,
- Stéphanie Debette, MD, PhD,
- Mohammad A. Ikram, MD,
- Will T. Longstreth, MD,
- Reinhold Schmidt, MD,
- Cathy R. Zhang, MA,
- Qiong Yang, PhD,
- Pankaj Sharma, MD, PhD, FRCP,
- Steven J. Kittner, MD,
- Braxton D. Mitchell, PhD,
- Elizabeth G. Holliday, PhD,
- Christopher R. Levi, MD,
- John Attia, MD,
- Peter M. Rothwell, FMedSci,
- Deborah L. Poole, BSc,
- Giorgio B. Boncoraglio, MD,
- Bruce M. Psaty, MD, PhD,
- Rainer Malik, PhD,
- Natalia Rost, MD,
- Bradford B. Worrall, MD, MSc,
- Martin Dichgans, MD,
- Tom Van Agtmael, PhD,
- Daniel Woo, MD,
- Hugh S. Markus, DM,
- Sudha Seshadri, MD,
- Jonathan Rosand, MD and
- Cathie L.M. Sudlow, MD, PhD
- On behalf of the METASTROKE Consortium, the CHARGE WMH Group, the ISGC ICH GWAS Study Collaboration, the WMH in Ischemic Stroke GWAS Study Collaboration, and the International Stroke Genetics Consortium
- Kristiina Rannikmäe, MD,
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Edinburgh and Lothians Health Foundation REMIND Fund and Stroke Research and Amenities Endowments Fund
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- Gail Davies, PhD,
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- Pippa A. Thomson, PhD,
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(1) The National Institute of Mental Health (NIMH) USA,1R01MH102068-01, Co-investigator, October 2013- September 2016.
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- Steve Bevan, BSc, PhD,
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- William J. Devan, BSc,
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- Guido J. Falcone, MD, ScD, MPH,
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NINDS, Grant number P50NS061343, research fellow, 2013.
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- Matthew Traylor, MSc,
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- Christopher D. Anderson, MD, MMSc,
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(1) Fellowship in Therapeutic Development, Biogen Idec, Inc.
(1) NIH-NINDS K23 NS086873-01
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(1) American Brain Foundation Clinical Research Training Fellowship
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- Thomas W.K. Battey, BS,
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- Farid Radmanesh, MD, MPH,
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- Ranjan Deka, PhD,
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Supported by the following grants: T32 NIEHS 010957-11 (Principal Investigator) 07/01/2011 - 06/30/2015; Molecular Epidemiology in Children?s Environmental Health Training Program R01 NIH HL093093 (Sub Contract PI) 09/01/2009 12/31/2014; Genome-Wide Association Study of Adiposity in Samoans P30 NIH ES006096 (Co-Investigator) 04/01/2008 - 03/31/2015; Center for Environmental Genetics R01 NIH NS036695 (Co-Investigator) 09/12/1997 - 06/30/2014; Genetic and Environmental Risk Factors for Hemorrhagic Stroke
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- Jessica G. Woo, PhD,
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(1) International Pediatric Hypertension Association, travel expenses to present at American Society for Hypertension meeting, 2013
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(1) Mead Johnson Pediatric Nutrition Institute, Inc.
(1) NIH/NINDS R01 NS36695, Subcontract PI, 2008-2014.
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- Lisa J. Martin, MD,
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Frontiers in Applied Genetic Epidemiology, 2013 - present, Associate Editor
Adiponectin for Treatment of Various Disorders, Patent # 8,314,061
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(1) NIH/NINDS, R01 NS036695, Co-Investigator, 07/01/08 ? (2) NIH/ NIAID, U19 AI070235,PI, 09/15/06 ? 08/31/16 (3) NIH, U19 AI066738-07, Co-Investigator, 07/01/10 - 06/30/15 (4) NIH, R01 HL111459-01, Co-Investigator, 09/01/11 ? 08/31/16 (5) NIH/ NHLBI,R24 HL105333-01A1,Co-Investigator, 03/03/12-02/28/17 (6) NIH/NIAID, R21AI101375-01A1, Co-Investigator, 7/1/2012-6/30/2014 (7) NIH, R01 HL116906-01A1, Co-Investigator, 7/1/2013-6/30/2018
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- Jordi Jimenez-Conde, MD, PhD,
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IMIM-Hospital del Mar, Adjunct Neurologist
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(1) NINDS/NI, U01NS069208, Center PI,2011-14, (2) ISCIII/Spanish Government Grants, PI10/02064, PI, 2011-13
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La Marat? TV3,76/C/2011, PI, 2012-15 Recercaixa 2013, JJ086116, PI, 2014-2016
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- Magdy Selim, MD, PhD,
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Stroke - Co-editor; Controversies Section. 2010-present Translational Stroke Research - Editorial Board Member. 2011- present Interventional Neurology - Editorial Board Member. 2013- present
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The Stroke Book; Cambridge University Press Neurology Emergencies; Oxford University Press
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NIH/NINDS U01 NS074425 Principal Investigator
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- Devin L. Brown, MD, MS,
Steering Committee Member, Northern Manhattan Initiative for Minority involvement in Clinical Trials (NIMICT) (U24MD006961)
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Wayne State University, honorarium for talk.
(1) Neurology, editorial board member, 2008-present (2) Stroke, editorial board member, 2011-present
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CVR Global, Inc, 12/12/08 ? 06/30/10, research grant.
AHRQ, R18 HS017690, Co-I, 12/1/09 ? 11/30/13 NINDS, R01 NS062675, PI, 06/15/09 ? 05/31/14 NHLBI, R01 HL098065, PI, 06/01/10 ? 05/31/14 NINDS, R01 NS070941, PI, 05/01/11 - 04/30/16 NIH, R01 DC012760, Co-I, 08/1/13 - 07/31/18 NINDS, U10NS086526, PI, 09/01/13 - 07/01/18
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(1) Blue Cross Blue Shield of Michigan Foundation, (2) Michigan Department of Community Health
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- Scott L. Silliman, MD,
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Biogen Novartis Genzyme Schering Plough
NIH/NINDS -1 R01 NS 44876-01A2 2004-present
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- Chelsea S. Kidwell, MD,
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Editorial Board Member, Neurocritical Care Journal, 2003- present Editorial Board Member, Journal of Neuroimaging, 2004- present Editorial Board Member, Stroke Research and Treatment, 2009-present Editorial Board Member, Stroke, 2011-present
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Baxter, 2009-2012
NIH-NINDS, Co-Investigator P50 NS044378, 7/22/08-7/30/13 NIH-NINDS, PI U54 NS057405, 09/01/07-08/31/12 NIH-NINDS, Co-Investigator U01 NS069763, 7/1/10-6/30/15 NIH-NIMHD, Project PI, P60 MD006920 12/1/11-11/30/16
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- Joan Montaner, MD, PhD,
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- Carl D. Langefeld, PhD,
(2) Oklahoma Medical Research Foundation, Wake Forest Nonhuman Primate Center, Wake Forest Research Advisory Committee for IT
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(2)NIH; Alliance for Lupus Research Grant Reviewer Functional Genomics and Molecular Pathways; Scleroderma Foundation Grant Reviewer; Medical University of South Carolina, Rheumatology Research Conference; University of Tampa; Kings College, London; University of Alabama at Birmingham
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University of Alabama at Birmingham grant on African American GWAS for Arthritis;
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NIH R01 NS36695, Genetic and Environmental Risk Factors for Hemorrhagic Stroke (Langefeld, PI of subcontract, 5% effort); NIH R21 DK097524, Genetic Architecture of Obesity and Inflammation in Hispanic Americans (Langefeld, Co-PI, 8% effort); NIH U01 NS069763-01, Minorities with Ischemic Stroke Study (ERICH) (Langefeld, PI Data Coordinating Center, 5% effort); NIH P01 AR048929, Gene Expression in Pediatric Arthritis (Thompson, PI; Langefeld, PI Data Analysis Core, 5% effort); NIH 1R01HL114587-01A1, Genetic Risk for Granulomatous Interstitial Lung Disease (Langefeld, PI of subcontract, 4% effort); NIH R01 HL092301, Whole Genome Association Analysis of the Diabetes Heart Study (Langefeld, Co-I, 7.5% effort); NIH R01 DL066358, Genetics of African American Type 2 Diabetes (Langefeld, Co-I, 5% effort); NIH R01 DK085175-11A1, Genetic & Epidemiologic Predictors of Glucose Homeostasis measures in Hispanics (Langefeld, Co-I, 5% effort); NIH R01 DK535391, Mapping Genes for NIDDM Nephropathy in African Americans (Langefeld, Co-I, 4% effort); NIH R01 DK090111- 01, Mapping Diabetes Susceptibility by expression traits in African Americans (Langefeld, Co-I, 10% effort); NIH R01DK070941, An Integrative Genomic Approach to APOL1- Associated Nephropathy (Freedman, PI; Langefeld, Co-I, 2% effort); NIH R01 HG007112, Exome sequencing to identify CVD risk variants in Hispanics and African Americans (Langefeld, Co-PI, 10% effort); NIH R01 DK71891, Subclinical CVD in African American Type 2 Diabetes (Langefeld, Co-I, 4% effort); NIH 5R01CA166825-02, New and Integrated Perspectives on modification of Tamoxifen Effectiveness (Langefeld Co-I, 3% effort); NIH 5R01HL119962-02, The Role of Hepatocyte ABCA1 in Lipid Metabolism and Transport (Langefeld, Co-I, 1% effort); NIH 1UG1CA189824-01, Wake Forest NCORP Research Base (Role Langefeld Co-I, 1% effort) NIH funding completed in past two years: NIH/NIAMS, Genetics of Juvenile Idiopathic Arthritis and Subtypes (Langefeld, PI); NIH/NIAMSD, Program Project in the Genetics of SLE (Langefeld PI Data Analysis Core); NIAMS, Gene Mapping in Women with Systemic Lupus Erythematosus (Langefeld PI subcontract); NIH, Lupus Nephritis and Renal Failure: A National Consortium to Explore the Genotypic Basis for Immune-Mediated ESRD (Langefeld PI Biostatistics and Bioinformatics Core); NIH/NIDDK, Subclinical CVD in African American Type 2 Diabetes (Langefeld, Co-I); NINDS, Genetic Epidemiology of Cerebrovascular Disease and Cognition in Diabetes (Langefeld, Co-I); NIH, Integration of Functional and Molecular Genetics to Identify Diabetes Genes (Langefeld, Co-I); NIH, Natural History of MYH9-Associated Nephropathy (Langefeld, Co-I); NINDS Cerebrovascular Disease and Cognitive Performance in African Americans (Langefeld, Co-I); NIH, Genomics of Lupus (SLEGEN P01) (Langefeld, PI of Biostatistics and Bioinformatics Core); Medical College of South Carolina (Langefeld, PI of subcontract for analysis).
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Alliance for Lupus Research, ALS Association
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Finnegan, Henderson, Farabow, Garrett & Dunner, LLP (Expert witness for defendant)
- Agnieszka Slowik, MD,
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- Arne G. Lindgren, MD, PhD,
(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer
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(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer
(1) Neurologi i Sverige. 2011-2014. Editorial advisory board member.
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- James F. Meschia, MD,
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On the editorial boards of Mayo Clinic Proceedings and of Stroke.
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NINDS, grant R01 NS038384
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- Myriam Fornage, PhD,
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- Joshua C. Bis, PhD,
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- Stéphanie Debette, MD, PhD,
Scientific advisory board for the French National Recommendations on secondary stroke prevention (Haute Autorit? de Sant?, non-profit entity)
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editorial board of stroke
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Agence Nationale de la Recherche (French National Research Agency): chaire d'excellence junior 2010-2014; VASCOGENE project 2015-2020
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Leducq Foundation
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- Mohammad A. Ikram, MD,
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(1) Neuroepidemiology, Editorial board member, 2011-2014, (2) PLoS One, Academic Editor, 2013-2014
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(1) ZonMW, 916.13.054, PI, 2012-2016, (2) STW, #12723, PI, 2013-2017, (3) BBMRI, CP2013-67, PI, 2013-2014
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(1) Alzheimer Association, 2014-NIRG-305710, (2) Internationale Stichting Alzheimer Onderzoek, #12533, (3) Nederlandse Hartstichting, 2012T008 and 2009B102, (4) Stichting ParkinsonFonds, (5) Institute for scientific information on coffee, (6) Alzheimer Nederland Fellowship
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- Will T. Longstreth, MD,
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Dr. Longstreth is a co-investigator on several NIH-funded studies.
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- Reinhold Schmidt, MD,
Rivastigmin Patch, 2010, Novartis JSW Life Sciences 2010, Advisory Board for Dementia Trial Axon Neuroscience 2013 and 2014
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Received travel expenses and/or honoraria for lectures from Pfizer (2004-2010), Novartis (2003-2010), Merz Austria (2005-2010) and Lundbeck (2004-2009) and for educational activity from Takeda 2010
Editoral board member of Clinical Neurology and Neurosurgery 2004-currently
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Pfizer 2004-2010,lectures Novartis 2003-2010,2014 lectures Merz Austria 2005-2010, lectures Lundbeck 2004-2009, lectures Takeda, 2010, teaching course
QPS, Austria Axon Neuroscience
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Austrian Science Fund projects P20103 and I904
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- Cathy R. Zhang, MA,
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- Qiong Yang, PhD,
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NIH
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- Pankaj Sharma, MD, PhD, FRCP,
Bohringer 2009 & 2013 advisory board member 2013-14 Bayer advisory board member
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J Royal Soc Medicine Cardiovascular Disease Editor in Chief
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- Steven J. Kittner, MD,
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Editorial Board, Neuroepidemiology, 2000- present
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NINDS: 1U01NS069208, Co-PI, 2010-2013 NINDS: R01NS069763-01, Site PI
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- Braxton D. Mitchell, PhD,
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Diabetes, Associate Editor, 2009 - Diabetes/Metabolism Research and Reviews (Co-Editor, 2002-present) Diabetes Management (Editorial Advisory board, 2011-present)
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P60DK079637-02 (Wondisford) 03/05/13 ? 01/31/18 0.60 calendar NIH $250,000 (Johns Hopkins subcontract) Diabetes Research and Training Center In collaboration with Johns Hopkins University, the University of Maryland will develop a Baltimore Diabetes Research and Treatment Center to provide rational interventions for the effective treatment and prevention of diabetes and related diseases. P30 DK072488-06 (Shuldiner) 09/15/05 - 08/31/15 0.90 calendar NIH $807,956 Mid-Atlantic Nutrition Obesity Research Center The NORC will focus on the influence of nutrition and exercise on risk for age-related chronic diseases, including obesity, type 2 diabetes, hypertension, cardiovascular disease (CVD), sleep disordered breathing, and osteoporosis. U01HL105198-06 (Shuldiner) 04/10/10 ? 03/31/15 1.80 calendar NIH $1,941,032 Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study The major goal of this randomized clinical trial is to provide evidence base for translation of genotype-directed anti-platelet therapy into clinical practice. U01NS069208 (Kittner) 07/01/10 - 06/30/14 2.40 calendar NIH $449,701 The NINDS Ischemic Stroke Genetics Consortium The major goal of this project is to establish a consortium to perform a large sample size genome-wide association study for ischemic stroke using both previously genotyped and samples that need genotyping and to replicate and extend findings from discovery sample through international collaboration with other genome-wide association studies. R01MH085646-01 (Hong) 07/01/10 ? 05/31/201 0.60 calendar NIH $377,779 Neural Oscillatory Biomarkers for Genetics and Animal Model Schizophrenia This application proposes to critically examine the relevance of neural oscillatory response in the genetics of schizophrenia and test the overall hypothesis that neural oscillatory signals may serve as key biomarkers for the genetics and translational studies for schizophrenia R01DK088231-01 (Gerhard) 12/01/10 ? 11/30/15 0.50 calendar NIH $120,586 (sub with Geisinger Clinic) Genetic Determinants of Weight Loss and Resolution of Co-Morbidities The goal of this project is to identify common and rare gene variants that are associated with weight loss and improvement in metabolic traits following bariatric surgery. R01 AR052873-07 (Abramson) 07/01/12-06/30/17 0.60 calendar NIH $40,565 (UMD subcontract) Leukocyte Gene Expression and Genetic Biomarkers of OA Incidence and Progression This project seeks to identify inflammation-related genetic, proteomic, and lipidomic biomarkers that predict progression of osteoarthritis in symptomatic patients. MITCHELL, Braxton D. (active continued) R01 EB015611-01 (Kochunov) 08/01/12 ? 07/31/15 0.60 calendar NIH $859,322 SOLAR-Eclipse Computational Tools for Imaging Genetics The goal of this study is to develop tools and computational methods for integrating and analyzing multidimensional imaging data in genetic studies. P30 NR014129-01 (Dorsey) 09/27/12 ? 08/31/17 0.60 calendar NIH $45,284 (Genomics Core only) Center for Genomics of Pain This center provides support for investigators at the University of Maryland seeking to use genomic approaches to understand the etiology and treatment of pain. R01 NS073346 (Shuldiner) 03/15/11 ? 02/28/14 0.90 calendar NIH $94,309 (UMD subcontract) Secondary Prevention of Subcortical Stroke Prevention Genetic Substudy Timing The goal of this project is to identify genetic determinants of recurrent stroke, including those mediated by response to clopidogrel and other antiplatelet agents. No number (Puett, Mitchell, Co-PIs) 08/01/13-07/31/14 0 calendar Univ Maryland Research and Innovation Seed Program $70,660 Ambient Air pollution and Metabolic Syndrome in the Lancaster County Amish This project will develop preliminary data on the relationship of air pollution exposures, using state of the art spatio-temporal statistical models, and their relationship to metabolic and cardiovascular health in this unique population of Old Order Amish. R01 HL121007-01 (Mitchell) 01/15/14-11/30/17 1.56 calendar NIH $276,108 Identification and Functional Characterization of a Gene Influencing LDL-C on 5q
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- Elizabeth G. Holliday, PhD,
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Australian National Health and Medical Research Council (NHMRC), APPID 631096, Chief Investigator, 2010-2014
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- Christopher R. Levi, MD,
Apixaban Scientific Advisory Board - Pfizer National Stroke Foundation (Australia) Research Advisory Committee
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Received travel expenses and/or honoraira for lectures or educational activities not funded by industry
Advisory Board - Medicine Today, Since 2009 Associate Editor - BMC Neurology, Since 2011
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Expert External Reviewer - Stroke and Neurology Service, The Alfred Hospital, Melbourne. 2012
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NHMRC Practitioner Fellowship 2013-17 NHMRC Project and Partnership Grants 2000-2017 Australian Brain Foundation Project Grants
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National Stroke Foundation, Australia
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- John Attia, MD,
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- Peter M. Rothwell, FMedSci,
Exec Committee of the ARRIVE trial - payment for time.
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Unpaid editorial board roles for Trials, Lancet Neurology, BMJ and International Journal of Stroke.
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Too many to list - but all are non-commercial and none have any relationship to this study.
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Too many to list - but all are non-commercial and none have any relationship to this study.
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- Deborah L. Poole, BSc,
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- Giorgio B. Boncoraglio, MD,
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- Bruce M. Psaty, MD, PhD,
Psaty serves on the DSMB of a clinical trial for a device funded by the manufacturer (Zoll LifeCor) and on the Steering Committee for the Yale Open Data Access project funded by Johnson & Johnson.
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Contributing writer for JAMA.
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Listed in the acknowledgement
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- Rainer Malik, PhD,
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- Natalia Rost, MD,
(1) Genzyme Co. (2) Daiichi Sankyo
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Daiichi Sankyo, travel/speaker honoraria
Stroke, Assistant Editor, 2010
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NIH/NINDS K23NS064052 (PI), 2009-2014 NIH/NINDS R01NS082285 (PI), 2013 -current
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(1) National Stroke Association (2) American Stroke Association-Bugher Foundation
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- Bradford B. Worrall, MD, MSc,
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Neurology: Associate Editor 1 July 2009 - present Seminars in Neurology Editorial Board 2006-2014
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Chapter Author for Merritt's Neurology editions 10, 11, and 12.
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NINDS/NIH U-01 (RFA-NS-09-002) The NINDS International Stroke Genetics Consortium Study; Co-Principal Investigator, co-Chair of Phenotyping core; 3/31/10- 8/31/15 NHGRI/NIH U-01 HG005160 Pharmocogenomic studies in VISP: results and implications for clinical trial design - Part of the Genomics and Randomized Trials Network (GARNET); Co-Principal Investigator, Co-chair phenotype harmonization subcommittee, Chair incidental findings subcommittee, Member of Steering and Publications committees; 9/09-1/31/14 NINDS/NIH U01 NS NS069763 The Ethic/ Racial varieation in IntraCerebral Hemorrhage (ERICH) study - Daniel Woo PI. Site Investigator NHLBI (contract no grant #) Cardiovascular Substudy to Age-Related Eye Disease Study 2 (AREDS2); Principal Investigator, cerebrovascular outcomes adjudicator; 01/01/09- 12/31/12 NINDS - R25 NS065733 NINDS Research Education program for Residents and Fellows at the University of VA; Mentor; March 2009- February 2014 NINDS/NIH- R01 NS42147 Discovery for Warfarin-Related Intracerebral Hemorrhage (GOCHA); Site PI; 12/04-8/14 NINDS/NIH- R01 NS039512 Familial Intracranial Aneurysm Study (FIA) ; Executive committee member, site co-investigator; 2/1/99-8/31/13
University of Virginia - CENETERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Prinicpal Investigator 10/13-9/15
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- Martin Dichgans, MD,
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(1) Bayer Vital, travel expenses and honoraria for lectures, (2) Boehringer Ingelheim Pharma, travel expenses and honoraria for lectures, (3) Heel, travel expenses and honoraria for lectures, (4) Bristol-Meyer Squibb, travel expenses and honoraria for lectures, (5) Lundeck, travel expenses and honoraria for lectures, (6) Sanofi- Aventis, travel expenses and honoraria for lectures, (7) Shire, travel expenses and honoraria for lectures, (8) German Research Foundation (DFG), research support, (9) Vascular Dementia Research Foundation, research support, (10) Corona Foundation, research support, (11) Jackst?dt Foundation, research support.
(1) Stroke the International Journal of Stroke, editor, (2) Cerebrovascular diseases, editorial board member, (3) Journal of Neurochemistry, editor
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(1) Bayer Vital, (2) Boehringer Ingelheim, (3) Bristol- Meyer Squibb, (4) Heel
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(1) Wellcometrust, 03/08 following, (2) European Union (EU FP 7), investigator, 10/13-09/16, (3) German Federal Ministry of Education and Research (BMBF), investigator, 12/13-11/16, (4) European Union (EU FP 6), investigator, 03/12-02/15
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(1) Vascular Dementia Research Foundation, (2) Corona Foundation, (3) Jackst?dt Foundation
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- Tom Van Agtmael, PhD,
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(1) Kidney Research UK Grant number (RP19/2012)
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- Daniel Woo, MD,
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(1) Stroke Research and Treatment, Associate Editor, 2010-2014.
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NIH Funding: NS36695 (PI: 1998-Current); NS30678 (CoI: 1998-Current). NS69763 (PI: 2010-Current).
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- Hugh S. Markus, DM,
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Section editor International Journal of stroke editorial board Clin Neurology and Neurosurgery
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Stroke Medicine OUP. 2010
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NINDS for SIGN genetics grant
Stroke Association, EU, Wellcome Trust, The British Heart Foundation, Alzheimer Research for peer reviewed research grants
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- Sudha Seshadri, MD,
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Journal of Alzheimer's Disease, Associate Editor since 2005. Stroke: Editorial Board since 2010. Neurology: Editorial Board since 2011.
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NIH/NIA: Grant number: R01 AG08122 (PI: Seshadri, Wolf); role: PI (Multiple PI grant) 08/01/10-07/31/16; NIH/NINDS: Grant number R01 NS017950 (Wolf); role: investigator; 07/01/09-6/31/14; NIH/NIA: 1 R01 AG033040-01 (PI: Wolf); role: investigator; 01/15/09-12/31/13; NIH/NIA: Grant number: R01 AG033193(PI: Seshadri); 02/01/09-01/31/17 NIH/NIA: Grant Number: U01 AG49505 (PI: Seshadri) 08/01/14-08/01/18
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- Jonathan Rosand, MD and
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Lancet Neurology, editorial board member Stroke, editorial board member
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Boehringer Ingelheim
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NINDS, R01NS059727 NINDS, R01NS073344 NINDS, U01NS069208 NINDS, U01NS069763
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Boehringer Ingelheim, consultant
- Cathie L.M. Sudlow, MD, PhD
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(1) Scottish Executive Health Department 01/04/2008-2013 Chief Scientist Office Project Grant (co-applicant) (principal investigator Dr Brian McKinstry, University of Edinburgh) ?Telemetric supported self-monitoring of long-term conditions.'
(1) British Heart Foundation 2012-2017 RESTART trial of antiplatelet treatment in ICH ( co- applicant) (2) UKBiobank 01/05/2012-ongoing Stroke Outcomes Pilot (principal applicant) (3) UK Biobank 01/09/2012-ongoing chief scientist support (principal applicant) (4) NIH via University of Maryland Stroke GWAS sub award for stroke phenotyping 01/06/2011-31/12/2013
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- Correspondence to Dr. Sudlow: cathie.sudlow{at}e.ac.uk
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