The association between the street drug spice (K-2 or herbal incense), a synthetic marijuana, and intracranial hemorrhage (ICH) has not yet been described, but it has with acute ischemic stroke (AIS),1 seizure, and myocardial infarction.2 Two young patients (31 and 25 years old) independently presented to our hospital with subarachnoid hemorrhage (SAH) after spice inhalation. The first also had 2 large intraparenchymal hemorrhages (IPH); the other also had AIS. Both were previously healthy without hypertension, coagulopathy, bleeding diathesis, thrombocytopenia, intracranial aneurysm, arteriovenous malformation, connective tissue disease, or anticoagulant/antiplatelet medication use.
Footnotes
Author contributions: David Z. Rose: drafting/revising the manuscript for content. Waldo R. Guerrero: drafting/revising the manuscript for content. Maxim V. Mokin: drafting/revising the manuscript for content. Clifton L. Gooch: drafting/revising the manuscript for content. Andrea C. Bozeman, ARNP: drafting/revising the manuscript for content. Julia M. Pearson: drafting/revising the manuscript for content. W. Scott Burgin: drafting/revising the manuscript for content.
Study funding: No targeted funding reported.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received February 9, 2015.
- Accepted in final form May 11, 2015.
- © 2015 American Academy of Neurology
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