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October 20, 2015; 85 (16) Article

Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes

Ilaria Maestrini, Daniel Strbian, Sophie Gautier, Elena Haapaniemi, Solène Moulin, Tiina Sairanen, Nelly Dequatre-Ponchelle, Gerli Sibolt, Charlotte Cordonnier, Susanna Melkas, Didier Leys, Turgut Tatlisumak, Régis Bordet
First published September 11, 2015, DOI: https://doi.org/10.1212/WNL.0000000000002029
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Article Information

vol. 85 no. 16 1408-1416
DOI: 
https://doi.org/10.1212/WNL.0000000000002029
PubMed: 
26362283
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 1, 2015
  • Accepted in final form May 11, 2015
  • First Published September 11, 2015.

Article Versions

Copyright & Usage: 
© 2015 American Academy of Neurology

Author Disclosures

    1. Ilaria Maestrini, MD,
    2. Daniel Strbian, MD, PhD, FESO,
    3. Sophie Gautier, PharmD, PhD,
    4. Elena Haapaniemi, MD, PhD,
    5. Solène Moulin, MD, MSc,
    6. Tiina Sairanen, MD, PhD,
    7. Nelly Dequatre-Ponchelle, MD, MSc,
    8. Gerli Sibolt, MD,
    9. Charlotte Cordonnier, MD, PhD,
    10. Susanna Melkas, MD, PhD,
    11. Didier Leys, MD, PhD, FESO,
    12. Turgut Tatlisumak, MD, PhD, FESO and
    13. Régis Bordet, MD, PhD
  1. Ilaria Maestrini, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) European Society of Neurology (2) La Revue Neurologique

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Daniel Strbian, MD, PhD, FESO,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) The Helsinki University Central Hospital (HUCH) governmental subsidiary (EVO) funds for clinical research, minor role, 2015-2016. (2) The Finnish Medical Foundation, funds for clinical research 2014-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Sophie Gautier, PharmD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Elena Haapaniemi, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Solène Moulin, MD, MSc,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Tiina Sairanen, MD, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. received consultancy fees from Boehringer Ingelheim; participation in scientific meetings as representative of Dept. neurology, HUCH funded by Bayer Inc.,Orion Pharma inc., Teva Inc .

    Editorial Boards:

    1. Member of the Editorial Board of Experimental & Translational Stroke Medicine

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Nelly Dequatre-Ponchelle, MD, MSc,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Gerli Sibolt, MD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Charlotte Cordonnier, MD, PhD,
    10. Scientific Advisory Boards:

    1. Scientific Board: Bayer - no personal funding, fees given to ADRINORD

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Pfizer, Astra-Zeneca: as a clinical investigator for clinical trials. No personal funding.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Susanna Melkas, MD, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Didier Leys, MD, PhD, FESO,
    12. Scientific Advisory Boards:

    1. 1) Scientific advisory boards for Pharmaceutical or device companies (No direct honoraria received by myself : were paid to the research institution): BMS, Boeringher- Ingelheim, Bayer, Astrazeneca, Nestl?, Daiichy-Sankyo, ChandlerChicco 2) Member of DSMBs for institutional trials (no honoraria): INCH (Germany) and TO-ACT (the Netherlands)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Travel to the American Neurological Association meeting with the French Society of neurology, sponsored by Teva (flight and accomodation).

    Editorial Boards:

    1. Cerebrovascular Diseases. Editorial Board.

    Patents:

    1. NONE

    Publishing Royalties:

    1. Edition of a teaching book for students published in French (pr?parer l'examen classant national: neurologie. Editions Ellipse. Leys D and Defebvre L. 2004, 2008, 2012).

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. Symposia organised by Boeringher Ingelheim Bayer BMS (honoraria paid to the research institution)

    Other activities:

    1. Drug trials with Sanofi Aventis, Astrazeneca, Boeringher- Ingelheim, Brainsgate, Photothera, Lundbeck, GSK, Pierre Fabre. (Honoraria paid to Adrinord or to the hospital)

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Honoraria paid to the research institution (Adrinord) - Boeringher ingelheim (advisory boards in France and Europe)

    Research Support, Government Entities:

    1. PHRC grant EU grant

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Fondation Coeur et art?re (2012)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. Turgut Tatlisumak, MD, PhD, FESO and
    13. Scientific Advisory Boards:

    1. Boehringer-Ingelheim Mitsubishi Pharma PhotoThera BrainsGate H. Lundbeck A/S Orion Pharma Bayer Pfizer

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Professio Finland (speaker honoraria) Genzyme Oy (Finland, speaker honoraria) Congress traveling and accommodation costs: European Stroke Conference European Federation of Neurological Societies European Stroke Organisation L?ANTEL telemedicine conference (France) University of Rostock (Germany) University of Bielefeld (Germany) SITS International Boehringer Ingelheim University of Donau (Austria) Catholic University of Leuven (Belgium) Austrian Stroke Society University of Oulu (Finland) Nordic Stroke Conference Australia-NZ Stroke Association Polish Neuroscience Socitey Internal Medicine Socitey of Greece World Stroke Conference Thrombolysis and Thrombectomy in Acute Stroke Treatment Conference University of Tarto University of Tuebingen German Psychological Society

    Editorial Boards:

    1. Stroke, 2000-2006, 2010- Current Vascular Pharmacology, 2002- The Open Pharmacology Journal 2007-2010 Clinics of Turkey 2007-2012 Clinics of Turkey / Neurology 2007-2012 The Open Cardiovascular Medicine Journal 2007 Recent Patents on Biotechnology 2008 Recent Patents on CNS Drug Discovery, 2008-2010 Experimental and Translational Stroke Medicine, 2008-2009 Stroke Research and Treatment, 2009- BMC Journal of Experimental and Translational Stroke Medicine, 2009- Frontiers in Stroke, 2010- Case Reports in Neurology (founding editor-in-chief)2009- 2012 Cerebrovascular Diseases, 2011-2014 No compensation was received for any of the above editorial duties

    Patents:

    1. 1. Stanniocalcin proteins and nucleic acids and methods based thereon. Application No/ Patent No: WO0130969, Publication date: 2001-05-03, requested patent: EP1233778, Inventors: Olsen HS, Zhang K, Lindsberg P, Tatlisumak T, Kaste M, Andersson LC. Human Genome Sciences Inc (US), Application number: WO2000US29432 200001026 2. New Therapeutic Uses (method to prevent brain edema and reperfusion injury), PCT/FI2004/000070. Inventors: Lindsberg PJ, Karjalainen-Lindsberg M-L, Tatlisumak T, Strbian D. Applicant: Licentia Oy. Application date: February 13, 2003. Publication 7/2003, Application number: 20030224. 3. Thrombolytic compositions (method to prevent postthrombolytic hemorrhage formation), PCT/FI2004/000071. Inventors: Lindsberg PJ, Karjalainen- Lindsberg M-L, Tatlisumak T, Strbian D, Kovanen P. Applicant: Licentia Oy. Application date: February 13, 2003. Publication: 3/2003. Application number: 20030225.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Boehringer Ingelheim, PhotoThera, BrainsGate, H. Lundbeck A/B, Orion, Bayer, Pfizer

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Helsinki University Central Hospital Research Funds, PI European Union, EU FP7 202213, 2008-2012, PI Biocentrum Finland, 2010-2012 Biocentrum Helsinki, 2011, 2012, 2013, PI Finnish Academy of Sciences, 2012-2014, PI National Institutes of Health University of Gothenburg Research Funds, PI Sahlgrenska University Hospital Reserach Funds, PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Sigrid Juselius Foundation, 2010,2014, and 2015 PI Maire Taponen Foundation, 2012 and 2014 Liv och H?lsa 2012

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  13. Régis Bordet, MD, PhD
    14. Scientific Advisory Boards:

    1. Pharnext, Lundbeck

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Lundbeck, Otsuka

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Neurology (I.M., S.G., S. Moulin, N.D.-P., C.C., D.L., R.B.) and Pharmacology (S. Moulin, N.D.-P., C.C., D.L.), INSERM U 1171, University of Lille, UDSL; CHU Lille (S.G., R.B.), France; “Sapienza” University of Rome (I.M.), Italy; and the Department of Neurology (D.S., E.H., T.S., G.S., S. Melkas, T.T.), Helsinki University Central Hospital, Finland.
  1. Correspondence to Dr. Leys: didier.leys{at}univ-lille2.fr
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