Share

October 27, 2015; 85 (17) Article

Infection, vaccination, and childhood arterial ischemic stroke

Results of the VIPS study

Heather J. Fullerton, Nancy K. Hills, Mitchell S.V. Elkind, Michael M. Dowling, Max Wintermark, Carol A. Glaser, Marilyn Tan, Michael J. Rivkin, Luigi Titomanlio, A. James Barkovich, Gabrielle A. deVeber
First published September 30, 2015, DOI: https://doi.org/10.1212/WNL.0000000000002065
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
954

Share

Article Information

vol. 85 no. 17 1459-1466
DOI: 
https://doi.org/10.1212/WNL.0000000000002065
PubMed: 
26423434
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 26, 2015
  • Accepted in final form June 15, 2015
  • First Published September 30, 2015.

Article Versions

Copyright & Usage: 
© 2015 American Academy of Neurology

Author Disclosures

    1. Heather J. Fullerton, MD, MAS,
    2. Nancy K. Hills, PhD,
    3. Mitchell S.V. Elkind, MD, MS,
    4. Michael M. Dowling, MD, PhD,
    5. Max Wintermark, MD,
    6. Carol A. Glaser, DVM, MD,
    7. Marilyn Tan, MD,
    8. Michael J. Rivkin, MD,
    9. Luigi Titomanlio, MD, PhD,
    10. A. James Barkovich, MD and
    11. Gabrielle A. deVeber, MD, MSc
    12. On behalf of the VIPS Investigators
  1. Heather J. Fullerton, MD, MAS,
    2. Scientific Advisory Boards:

    1. I serve on a DSMB for the NIH for clinical trials related to sickle cell disease and stroke.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Stroke, member of editorial board, beginning 2015

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. R01 NS062820HJ (PI) NIH/NINDS Vascular Effects of Infection in Pediatric Stroke (VIPS) 08/05/2009 - 07/31/2015; NIH/NINDS - U54 - Stroke NETT - Principal Investigator - 08/01/2014 - 07/31/2018 NIH/NINDS - U01 - Stroke in the Young - Principal Investigator - 07/01/2014 - 07/31/2018 R01 NS062820-02S1(PI) NIH/NINDS Global Health Supplement to VIPS 08/01/2010 - 07/31/2011; K02 NS053883(PI) NIH/NINDS Independent Scientist Award The Role of Infection in Childhood Stroke 06/01/2006 - 08/31/2011 R01 HL096789-01RJ (Co-investigator) NIH/HSOD Prevention of Stroke after STOP (POST-STOP) 07/01/2009 - 06/30/2015

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Heart Association Established Investigator Award

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Nancy K. Hills, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Thrasher Research Foundation RAS-A116619 2/1/11-1/31/13 (no-cost extension until 1/31/14) Stimulants and Childhood Stroke (StaCS) This is a case-control study nested within the cohort of the 2.5 million children enrolled in KPMCP from 1993-2007 with the goal of determining whether ADHD medications increase the risk of childhood arterial ischemic stroke. Role: PI

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Mitchell S.V. Elkind, MD, MS,
    4. Scientific Advisory Boards:

    1. (1) Boehringer-Ingelheim, Inc., anticoagulants and stroke (2014-2015); (2) BMS-Pfizer Partnership,anticoagulants and stroke (2014-2015); (3) Daiichi-Sankyo, anticoagulants and stroke (2013-2014); (4) Janssen Pharmaceuticals, anticoagulants and stroke (2013-2014); (5)Biogen IDEC, natalizumab and stroke (2013); (6) Biotelemetry/Cardionet, monitoring for atrial fibrillation after stroke (2014)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Neurology, Resident and Fellow Section editor, published by American Academy of Neurology (2007-2015)

    Patents:

    1. NONE

    Publishing Royalties:

    1. UpToDate, 2015, chapters on cryptogenic stroke and hemicraniectomy for acute stroke

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) BMS-Pfizer Partnership, consultant regarding antithrombotics for stroke (2014)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. (1) American Heart Association National Board of Directors (2014-2016); (2) American Heart Association Founders Affiliate Board of Directors(2008-2013); (2) American Heart Association NY City Board of Directors (2011-2015)

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) diaDexus, Inc: funding for biomarker research; (2) BMS-Sanofi Pharmaceutical Partnership: funding for biomarker research

    Research Support, Government Entities:

    1. (1) NIH/NINDS R37 29993, PI, 2007-2020, (2) NIH/NINDS P50 NS049060, Project 1, PI, NeuSTART, 2004-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. (1) Organon/Merck, NuvaRing and stroke litigation, 2009-2015

  4. Michael M. Dowling, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board Member for the Journal of Child Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. I received honoraria for speaking at a board review course

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. I am a Pediatric Neurologist and I see children with stroke.

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. First Americal Real Estate Information Services, INC Children's Clinical Research Advisory Group (Research Support)

    Research Support, Foundations and Societies:

    1. Doris Duke Charitable Foundation (Grant)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Max Wintermark, MD,
    6. Scientific Advisory Boards:

    1. (1) Commercial entity: GE-NFL board

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. American Journal of Neuroradiology, editorial board since 2010 American Journal of Roentgenology, editorial board since 2010

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Carol A. Glaser, DVM, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Marilyn Tan, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Michael J. Rivkin, MD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Luigi Titomanlio, MD, PhD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Italian Journal of PEdiatrics, Associate Editor, 2014- present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. A. James Barkovich, MD and
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. European Course on Pediatric Neuroradiology

    Editorial Boards:

    1. American Journal of Neuroradiology Neuropediatrics

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Pediatric Neuroimaging, 4th Edition, Lippincott Williams & Wilkins, published 2005. 5th Edition published 2012. (2) Diagnostic Imaging: Brain, 2nd Edition, Amersys 2010

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NINDS R01 NS 046432 PI, 2009-2015 NIH/NIBIB R01 HD072074 CoI, 2013-2017 NIH/NINDS P01 NS082330 PI Project 1, CoI Core B NIH/NINDS R01 NS35129 PI of Subcontract

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Gabrielle A. deVeber, MD, MSc
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Auxilium Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

    1. From the Departments of Neurology (H.J.F., N.K.H., A.J.B.), Pediatrics (H.J.F., C.A.G., A.J.B.), Biostatistics and Epidemiology (N.K.H.), and Radiology (A.J.B.), University of California San Francisco; the Departments of Neurology and Epidemiology (M.S.V.E.), Columbia University College of Physicians and Surgeons and Mailman School of Public Health, New York, NY; the Departments of Pediatrics and Neurology and Neurotherapeutics (M.M.D.), UT Southwestern Medical Center, Dallas, TX; the Department of Radiology (M.W.), Stanford University, Palo Alto, CA; the Division of Communicable Disease Control (C.A.G.), Center for Infectious Diseases, California Department of Public Health, Richmond; the Departments of Pediatrics and Neurosciences (M.T.), University of the Philippines–Philippine General Hospital, Manila, Philippines; the Departments of Neurology, Psychiatry, and Radiology (M.J.R.), Boston Children's Hospital, MA; the Pediatric Emergency Department (L.T.), Robert Debré Hospital, Paris Diderot University, Paris, France; and the Department of Neurology (G.A.d.), Hospital for Sick Children, Toronto, Canada.
    1. Correspondence to Dr. Fullerton: Heather.Fullerton{at}ucsf.edu
    View Full Text

    Article usage

    Article usage: September 2015 to May 2022

    AbstractFullPdfSource
    Sep 20155201Highwire
    Oct 2015417516164Highwire
    Nov 201512995362Highwire
    Dec 20155534666Highwire
    Jan 20163001319Highwire
    Feb 20161301014Highwire
    Mar 20169345Highwire
    Apr 201693109Highwire
    May 20168347Highwire
    Jun 20169255Highwire
    Jul 20165916Highwire
    Aug 201656107Highwire
    Sep 201653910Highwire
    Oct 20166277Highwire
    Oct 2016031pmc
    Nov 20165253Highwire
    Nov 201603525pmc
    Dec 20164633Highwire
    Dec 201603314pmc
    Jan 20174722Highwire
    Jan 201701812pmc
    Feb 20174854Highwire
    Feb 201701214pmc
    Mar 20174834Highwire
    Mar 201702116pmc
    Apr 20174812Highwire
    Apr 2017172330pmc
    May 20174573Highwire
    May 2017173135pmc
    Jun 20174076Highwire
    Jun 2017113846pmc
    Jul 20173432Highwire
    Jul 201793856pmc
    Aug 20173556Highwire
    Aug 2017153445pmc
    Sep 20172721Highwire
    Sep 2017104039pmc
    Oct 20176342Highwire
    Oct 2017122825pmc
    Nov 20173320Highwire
    Nov 201791823pmc
    Dec 20174431Highwire
    Jan 20185376Highwire
    Feb 20183152Highwire
    Mar 20184011Highwire
    Apr 20184100Highwire
    Apr 201831718pmc
    May 20183500Highwire
    Jun 20183421Highwire
    Jun 201871010pmc
    Jul 20182811Highwire
    Aug 20184960Highwire
    Aug 201864645pmc
    Sep 20184011Highwire
    Oct 20187113Highwire
    Nov 20186921Highwire
    Dec 20186300Highwire
    Jan 20196821Highwire
    Feb 20194712Highwire
    Mar 20194520Highwire
    Apr 20192774Highwire
    May 20192622Highwire
    Jun 20191610Highwire
    Jul 20193220Highwire
    Aug 20192711Highwire
    Sep 20191822Highwire
    Oct 20194743Highwire
    Nov 20196901Highwire
    Dec 20195211Highwire
    Jan 20205210Highwire
    Feb 20203322Highwire
    Mar 20203731Highwire
    Apr 20201900Highwire
    May 20203211Highwire
    Jun 20203731Highwire
    Jul 20204130Highwire
    Aug 20204554Highwire
    Sep 20206122Highwire
    Oct 20205931Highwire
    Nov 20204632Highwire
    Dec 20206400Highwire
    Jan 20213812Highwire
    Feb 20214811Highwire
    Mar 20214311Highwire
    Apr 20216232Highwire
    May 20215021Highwire
    Jun 20215111Highwire
    Jul 20217000Highwire
    Aug 20219033Highwire
    Sep 20216433Highwire
    Oct 20215558Highwire
    Nov 20215765Highwire
    Dec 20214001Highwire
    Jan 20226421Highwire
    Feb 20227713Highwire
    Mar 202215420Highwire
    Apr 20227700Highwire
    May 20226810Highwire

    Cited By...

    Disputes & Debates: Rapid online correspondence

    No comments have been published for this article.
    Comment

    REQUIREMENTS

    If you are uploading a letter concerning an article:
    You must have updated your disclosures within six months: http://submit.neurology.org

    Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

    If you are responding to a comment that was written about an article you originally authored:
    You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
    and apply to letter.

    Submission specifications:

    • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
    • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
    • Submit only on articles published within 6 months of issue date.
    • Do not be redundant. Read any comments already posted on the article prior to submission.
    • Submitted comments are subject to editing and editor review prior to posting.

    More guidelines and information on Disputes & Debates

    Compose Comment

    More information about text formats

    Plain text

    • No HTML tags allowed.
    • Web page addresses and e-mail addresses turn into links automatically.
    • Lines and paragraphs break automatically.
    Author Information
    NOTE: The first author must also be the corresponding author of the comment.
    First or given name, e.g. 'Peter'.
    Your last, or family, name, e.g. 'MacMoody'.
    Your email address, e.g. higgs-boson@gmail.com
    Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
    Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
    Publishing Agreement
    NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

    Vertical Tabs

    You May Also be Interested in

    Back to top
    Advertisement

    Related Articles

    Topics Discussed

    Alert Me