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November 10, 2015; 85 (19) Article

Lower physical activity is associated with higher disease burden in pediatric multiple sclerosis

Stephanie A. Grover, Berengere Aubert-Broche, Dumitru Fetco, D. Louis Collins, Douglas L. Arnold, Marcia Finlayson, Brenda L. Banwell, Robert W. Motl, E. Ann Yeh
First published August 12, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001939
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Article Information

vol. 85 no. 19 1663-1669
DOI: 
https://doi.org/10.1212/WNL.0000000000001939
PubMed: 
26268901
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 30, 2015
  • Accepted in final form June 24, 2015
  • First Published August 12, 2015.

Article Versions

Copyright & Usage: 
© 2015 American Academy of Neurology

Author Disclosures

    1. Stephanie A. Grover, MSc,
    2. Berengere Aubert-Broche, PhD,
    3. Dumitru Fetco, MD,
    4. D. Louis Collins, PhD,
    5. Douglas L. Arnold, MD,
    6. Marcia Finlayson, PhD,
    7. Brenda L. Banwell, MD,
    8. Robert W. Motl, PhD and
    9. E. Ann Yeh, MD
  1. Stephanie A. Grover, MSc,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Berengere Aubert-Broche, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Dumitru Fetco, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. D. Louis Collins, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. consultant for NeuroRx Research, Montreal

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. consultant for NeuroRx Research, Montreal

    Research Support, Government Entities:

    1. Collins (PI) 06/01/2010 ? 09/31/2011 CECR Centres of Excellence Commercialization Research Grant ($85,050 total) Validation of MRI tools to facilitate the development of drugs to treat prodromal Alzheimer?s disease (MCI) Role: PI Collins (PI) 06/01/2010 ? 09/31/2011 CECR Centre of Excellence Commercialization and Research Grant MR Venography for Image Guided Neurosurgery ($57,500 total) Role: CO-PI Collins (PI) 04/01/2009 ? 03/31/2013 CHRP Collaborative Health Research Projects (NSERC & CIHR) Computational and statistical tools for image-guided neurosurgery of brain tumours ($628,198 total) Role: PI Collins (PI) 04/01/2009 ? 03/31/2013 CIHR Operating Grant Image guided neurosurgery: Improving guidance during spinal surgery ($ 1,004,631 total) Role: PI RGPIN238739-06 Collins (PI) 04/01/2006 ? 03/31/2012 NSERC Discovery grant Image guided surgery ($230,000 total). New tools for atlas creation and patient customization for image guided neuro surgery will be developed. Role: PI MOP 84367 Arnold (PI) 05/01/2007 ? 04/31/2012 CIHR Operating grant Magnetic resonance imaging of multiple sclerosis ($564,000 total). Development of MRI acquisition and processing tools for MS. Role: co-PI STPGP 350547 Collins (PI) 10/1/2007 ? 4/31/2011 NSERC Strategic grant ($648,000 total). Tissue segmentation in MRI Development and validation of lesion classification methods from multi-site MRI data. Role: PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Douglas L. Arnold, MD,
    6. Scientific Advisory Boards:

    1. Acorda Therapeutics, Biogen Idec, Serono, Genentech, Genzyme, GSK, Hoffman LaRoche, Innate Therapetuics, MedImmune, Mitsubishi, Novartis, Receptos, Opexa Therapeutics, Receptos, Roche, Sanofi-Aventis, Teva, Xenoport

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. Method of evaluating the efficacy of drug on brain nerve cells

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Biogen Idec, Novartis

    Research Support, Government Entities:

    1. CIHR 15630 co-PI 2007 2012 CIHR 84360 co-PI 2007-2012 CIHR 84367 PI 2007-2012 CIHR 111169 coPI 2011-2014 CIHR 43871 co-PI 2010-2015

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Multiple Sclerosis Society of Canada Multiple Sclerosis Research Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NeuroRx Research, 2002-2013

    Legal Proceedings:

    1. NONE

  6. Marcia Finlayson, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (1) Consortium of MS Centres, travel and speaker honoraria, (2) Rehabilitation in MS (RIMS), travel and speaker honararia, (3) National MS Education and Training Network, travel

    Editorial Boards:

    1. (1) International Journal of MS Care, board member, 2 years

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Multiple Sclerosis Rehabilitation: From Impairment to Participation, CRC/Taylor Francis, 2012;

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Canadian Institutes of Health Research, 129594, PI, 2013-14

    Research Support, Academic Entities:

    1. (1) Queen's University

    Research Support, Foundations and Societies:

    1. (1) Consortium of MS Centres (2) Multiple Sclerosis Society of Canada, (3) National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. 1) Falls Prevention Strategies Survey, copyright owned by University of Illinois at Chicago - receive a portion of license fees; (3) Safe at Home BAASE (falls prevention program for people with MS), copyright owned by University of Illinois at Chicago - receive a portion of license fees

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Brenda L. Banwell, MD,
    8. Scientific Advisory Boards:

    1. Scientific Advisory Board, Biogen-IDEC, Sanofi, Eli Lilly, Novartis.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. I have received speaker's honoraria or travel support to speak at sponsored meetings from Biogen-IDEC, Merck- Serono, Teva Neuroscience and Bayer. I have not received this for more than 2 years.

    Editorial Boards:

    1. I serve on the Editorial Board for Neurology. I receive no financial remuneration. I also serve on the Editorial Board for a new journal, Multiple Sclerosis and Related Disorders. I receive compensation for this work .

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. I have served as a consultant to Biogen-IDEC, Eli Lilly, Sanofi.

    Speakers' Bureaus:

    1. I have spoken at an event supported by the Consortium of MS Centers

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Canadian Institutes of Health Research

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Multiple Sclerosis Society of Canada Multiple Sclerosis Scientific Research Foundation National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Robert W. Motl, PhD and
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurorehabilitation and Neural Repair, Associate Editor, 2014-2015.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Biogen IDEC, (2) Acorda Therapeutics.

    Speakers' Bureaus:

    1. (1) EMD Serono

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Bioegn Idec, (2) Acorda Therapeutics

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) NMSS, RG 4491A3/1, PI, 2011-2015; (2) NMSS, RG 5144A6/1, PI, 2014-2018; (3) NMSS, MB 0029, PI, 2014-2019; (4) NMSS, IL 0017, PI, 2014-2015.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. E. Ann Yeh, MD
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology, editorial advisory board, 2013-present.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) CIHR, Co-I. PI: Pohl 2) PCORI, Co-I, CE-1304-7079 3) CMSMS (CIHI/PHAC), MS Monitoring system pilot funding

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) National MS Society HC 0148 2) National MS Society PP2256 3) MS Society (Canada) 4) Dairy Farmers of Ontario 5) SickKids Innovation Fund 6) MS Research Foundation (Canada) 7) Rare Diseases Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Division of Neurology (S.A.G., E.A.Y.), Department of Pediatrics, Hospital for Sick Children, University of Toronto, and Program in Neurosciences and Mental Health, SickKids Research Institute, Toronto, Ontario, Canada; Montreal Neurological Institute (B.A.-B., D.F., D.L.C., D.L.A.), McGill University; the School of Rehabilitation Therapy (M.F.), Faculty of Health Sciences, Queen's University, Kingston, Canada; the Division of Neurology (B.L.B.), the Children's Hospital of Philadelphia, PA; and the Department of Kinesiology and Community Health (R.W.M.), University of Illinois at Urbana-Champaign.
  1. Correspondence to Dr. Yeh: ann.yeh{at}sickkids.ca
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