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The advent of new effective therapies for relapsing-remitting (RR) multiple sclerosis (MS) has increased the expectations for disease control. This has made it crucial to use measures able to accurately evaluate the impact of therapeutic intervention, shifting the treatment paradigm of MS from partial response to remission.1
Footnotes
Author contributions: Nicola De Stefano: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval. Maria Laura Stromillo: analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data. Antonio Giorgio: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data. Marco Battaglini: analysis or interpretation of data, accepts responsibility for conduct of research and final approval. Maria Letizia Bartolozzi: study concept or design, accepts responsibility for conduct of research and final approval, acquisition of data. Maria Pia Amato: drafting/revising the manuscript, study concept or design, accepts responsibility for conduct of research and final approval, acquisition of data. Maria Pia Sormani: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, statistical analysis.
Study funding: Supported by a grant from FISM (Fondazione Italiana Sclerosi Multipla) Cod. 2010/R/15.
Disclosure: N. De Stefano has received honoraria from Schering, Biogen-Idec, Teva, Novartis, Genzyme, and Merck Serono S.A. for consulting services, speaking, and travel support. He serves on advisory boards for Merck Serono S.A. and Novartis. He has received research grant support from the Italian MS Society. M. Stromillo, A. Giorgio, M. Battaglini, and M. Bartolozzi report no disclosures relevant to the manuscript. M. Amato serves on scientific advisory boards for Biogen Idec, Merck Serono, Bayer Schering, Teva, and Sanofi Aventis and receives research support and honoraria for speaking from Biogen Idec, Merck Serono, Bayer Schering, Teva, Novartis, and Sanofi Aventis. M. Sormani has received personal compensation for consulting services and for speaking activities from Genzyme, Merck Serono, Teva, Synthon, Actelion, Novartis, and Biogen Idec. Go to Neurology.org for full disclosures.
- Received March 4, 2015.
- Accepted in final form July 13, 2015.
- © 2015 American Academy of Neurology
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