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December 01, 2015; 85 (22) Article

Moderate alcohol intake reduces risk of ischemic stroke in Korea

Soo Joo Lee, Yong-Jin Cho, Jae Guk Kim, Youngchai Ko, Keun-Sik Hong, Jong-Moo Park, Kyusik Kang, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jae Kwan Cha, Dae-Hyun Kim, Jun Lee, Joon-Tae Kim, Juneyoung Lee, Ji Sung Lee, Myung Suk Jang, Moon-Ku Han, Philip B. Gorelick, Hee-Joon Bae; On behalf of the CRCS-5 Investigators
First published October 30, 2015, DOI: https://doi.org/10.1212/WNL.0000000000002165
Soo Joo Lee
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Yong-Jin Cho
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Jae Guk Kim
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Youngchai Ko
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Keun-Sik Hong
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Jong-Moo Park
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Kyusik Kang
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Tai Hwan Park
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Sang-Soon Park
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Kyung Bok Lee
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Jae Kwan Cha
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Dae-Hyun Kim
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Jun Lee
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Joon-Tae Kim
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Juneyoung Lee
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Ji Sung Lee
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Myung Suk Jang
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Moon-Ku Han
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Philip B. Gorelick
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Hee-Joon Bae
From the Department of Neurology (S.J.L., J.G.K., Y.K.), Eulji University Hospital, Daejeon; Department of Neurology (Y.-J.C., K.-S.H.), Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do; Department of Neurology (J.-M.P., K.K.), Eulji General Hospital, Seoul; Department of Neurology (T.H.P., S.-S.P.), Seoul Medical Center; Department of Neurology (K.B.L.), Soonchunhyang University Hospital Seoul; Department of Neurology (J.K.C., D.-H.K.), Dong-A University Hospital, Busan; Department of Neurology (Jun Lee), Yeungnam University Medical Center, Daegu; Department of Neurology (J.-T.K.), Chonnam National University Hospital, Gwangju; Department of Biostatistics (Juneyoung Lee), Korea University College of Medicine, Seoul; Clinical Research Center (J.S.L.), Asan Medical Center, Seoul; Department of Neurology and Cerebrovascular Center (M.S.J., M.-K.H., H.-J.B.), Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea; and Department of Translational Science & Molecular Medicine (P.B.G.), Michigan State University College of Human Medicine and Medical Director, Mercy Health Hauenstein Neurosciences, Grand Rapids, MI.
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Citation
Moderate alcohol intake reduces risk of ischemic stroke in Korea
Soo Joo Lee, Yong-Jin Cho, Jae Guk Kim, Youngchai Ko, Keun-Sik Hong, Jong-Moo Park, Kyusik Kang, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jae Kwan Cha, Dae-Hyun Kim, Jun Lee, Joon-Tae Kim, Juneyoung Lee, Ji Sung Lee, Myung Suk Jang, Moon-Ku Han, Philip B. Gorelick, Hee-Joon Bae
Neurology Dec 2015, 85 (22) 1950-1956; DOI: 10.1212/WNL.0000000000002165

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Abstract

Objective: We undertook a population-based, case-control study to examine a dose-response relationship between alcohol intake and risk of ischemic stroke in Koreans who had different alcoholic beverage type preferences than Western populations and to examine the effect modifications by sex and ischemic stroke subtypes.

Methods: Cases (n = 1,848) were recruited from patients aged 20 years or older with first-ever ischemic stroke. Stroke-free controls (n = 3,589) were from the fourth and fifth Korean National Health and Nutrition Examination Survey and were matched to the cases by age (±3 years), sex, and education level. All participants completed an interview using a structured questionnaire about alcohol intake.

Results: Light to moderate alcohol intake, 3 or 4 drinks (1 drink = 10 g ethanol) per day, was significantly associated with a lower odds of ischemic stroke after adjusting for potential confounders (no drinks: reference; <1 drink: odds ratio 0.38, 95% confidence interval 0.32–0.45; 1–2 drinks: 0.45, 0.36–0.57; and 3–4 drinks: 0.54, 0.39–0.74). The threshold of alcohol effect in women was slightly lower than that in men (up to 1–2 drinks in women vs up to 3–4 drinks in men), but this difference was not statistically significant. There was no statistical interaction between alcohol intake and the subtypes of ischemic stroke (p = 0.50). The most frequently used alcoholic beverage was one native to Korea, soju (78% of the cases), a distilled beverage with 20% ethanol by volume.

Conclusions: Our findings suggest that light to moderate distilled alcohol consumption may reduce the risk of ischemic stroke in Koreans.

GLOSSARY

CI=
confidence interval;
CRCS=
Clinical Research Center for Stroke;
KNHANES=
Korea National Health and Nutrition Examination Survey;
OR=
odds ratio

Footnotes

  • The study results were presented at the International Stroke Conference 2014, San Diego, CA, February 12–14, 2014.

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • CRCS-5 coinvestigators are listed on the Neurology® Web site at Neurology.org.

  • Supplemental data at Neurology.org

  • Received March 16, 2015.
  • Accepted in final form August 3, 2015.
  • © 2015 American Academy of Neurology
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Letters: Rapid online correspondence

  • ALDH Polymorphism, drinking habits and risk of stroke
    • Hee-Joon Bae, Professor, Seoul National University College of Medicine & Bundang Hospital, Republic of Koreabraindoc@snu.ac.kr
    • Republic of Korea
    Submitted February 17, 2016
  • Re: Moderate alcohol intake reduces risk of ischemic stroke in Korea
    • Bossng Kang, professor, Hanyang University Guri Hospital, Department of Emergency Medicine, Koreaolivertwkbs@gmail.com
    Submitted November 16, 2015
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