Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
    • Without Borders
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
    • Article CME
    • Podcast CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
    • Without Borders
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
    • Article CME
    • Podcast CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

August 04, 2015; 85 (5) Article

Cognitive correlates of white matter lesion load and brain atrophy

The Northern Manhattan Study

Chuanhui Dong, Nooshin Nabizadeh, Michelle Caunca, Ying Kuen Cheung, Tatjana Rundek, Mitchell S.V. Elkind, Charles DeCarli, Ralph L. Sacco, Yaakov Stern, Clinton B. Wright
First published July 8, 2015, DOI: https://doi.org/10.1212/WNL.0000000000001716
Chuanhui Dong
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nooshin Nabizadeh
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michelle Caunca
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Kuen Cheung
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tatjana Rundek
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mitchell S.V. Elkind
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles DeCarli
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph L. Sacco
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yaakov Stern
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Clinton B. Wright
From the Evelyn F. McKnight Brain Institute (C. Dong, N.N., M.C., T.R., R.L.S., C.B.W.); Departments of Neurology (R.L.S., C.D., N.N., T.R., C.B.W.), Human Genetics (R.L.S.), and Epidemiology and Public Health Sciences (T.R., R.L.S., C.B.W.); and Neuroscience Program (R.L.S., C.B.W.), Miller School of Medicine, University of Miami, Miami, FL; Departments of Biostatistics (Y.K.C.) and Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (M.S.V.E.) and Psychiatry (Y.S.), the Gertrude H. Sergievsky Center (M.S.V.E., Y.S.), and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Y.S.), Columbia University College of Physicians and Surgeons, New York, NY; and Department of Neurology and the Center for Neuroscience (C. DeCarli), University of California at Davis, Sacramento, CA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Cognitive correlates of white matter lesion load and brain atrophy
Chuanhui Dong, Nooshin Nabizadeh, Michelle Caunca, Ying Kuen Cheung, Tatjana Rundek, Mitchell S.V. Elkind, Charles DeCarli, Ralph L. Sacco, Yaakov Stern, Clinton B. Wright
Neurology Aug 2015, 85 (5) 441-449; DOI: 10.1212/WNL.0000000000001716

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
330

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number)

Non-AAN Member subscribers: Sign in with subscriber credentials

Log in using your username and password

Forgot your user name or password?

Purchase access

AAN members must change their passwords on the AAN site

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Topics Discussed

  • MRI
  • Cohort studies
  • Risk factors in epidemiology
  • Cognitive aging
  • Volumetric MRI

Alert Me

  • Alert me when this article is cited
  • Alert me if a correction is posted
  • Alert me when eletters are published
Neurology: 93 (24)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2019 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise