Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

January 05, 2016; 86 (1) Article

Relationship of regional brain β-amyloid to gait speed

Natalia del Campo, Pierre Payoux, Adel Djilali, Julien Delrieu, Emiel O. Hoogendijk, Yves Rolland, Matteo Cesari, Michael W. Weiner, Sandrine Andrieu, Bruno Vellas, For the MAPT/DSA Study Group
First published December 7, 2015, DOI: https://doi.org/10.1212/WNL.0000000000002235
Natalia del Campo
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pierre Payoux
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adel Djilali
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julien Delrieu
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emiel O. Hoogendijk
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yves Rolland
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matteo Cesari
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael W. Weiner
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sandrine Andrieu
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruno Vellas
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
From Gérontopôle, Institute of Ageing (N.d.C., J.D., E.O.H., Y.R., M.C., B.V.), and the Department of Epidemiology and Public Health (S.A.), University Hospital Toulouse, France; the Department of Psychiatry (N.d.C.), University of Cambridge, UK; INSERM U825 (P.P., A.D.) and INSERM UMR 1027 (M.C., S.A., B.V.), University Toulouse III Paul Sabatier, France; Department of Epidemiology & Biostatistics (E.O.H.), EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; and the Departments of Radiology (M.W.W.), Medicine (M.W.W.), Psychiatry (M.W.W.), and Neurology (M.W.W.), University of California, San Francisco.
Full PDF
Citation
Relationship of regional brain β-amyloid to gait speed
Natalia del Campo, Pierre Payoux, Adel Djilali, Julien Delrieu, Emiel O. Hoogendijk, Yves Rolland, Matteo Cesari, Michael W. Weiner, Sandrine Andrieu, Bruno Vellas, For the MAPT/DSA Study Group
Neurology Jan 2016, 86 (1) 36-43; DOI: 10.1212/WNL.0000000000002235

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
478

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: To investigate in vivo the relationship of regional brain β-amyloid (Aβ) to gait speed in a group of elderly individuals at high risk for dementia.

Methods: Cross-sectional associations between brain Aβ as measured with [18F]florbetapir PET and gait speed were examined in 128 elderly participants. Subjects ranged from healthy to mildly cognitively impaired enrolled in the control arm of the multidomain intervention in the Multidomain Alzheimer Preventive Trial (MAPT). Nearly all participants presented spontaneous memory complaints. Regional [18F]florbetapir (AV45) standardized uptake volume ratios were obtained via semiautomated quantitative analysis using the cerebellum as reference region. Gait speed was measured by timing participants while they walked 4 meters. Associations were explored with linear regression, correcting for age, sex, education, body mass index (BMI), and APOE genotype.

Results: We found a significant association between Aβ in the posterior and anterior putamen, occipital cortex, precuneus, and anterior cingulate and slow gait speed (all corrected p < 0.05). A multivariate model emphasized the locations of the posterior putamen and the precuneus. Aβ burden explained up to 9% of the variance in gait speed, and significantly improved regression models already containing demographic variables, BMI, and APOE status.

Conclusions: The present PET study confirms, in vivo, previous postmortem evidence showing an association between Alzheimer disease (AD) pathology and gait speed, and provides additional evidence on potential regional effects of brain Aβ on motor function. More research is needed to elucidate the neural mechanisms underlying these regional associations, which may involve motor and sensorimotor circuits hitherto largely neglected in the pathophysiology of AD.

GLOSSARY

Aβ=
β-amyloid;
AD=
Alzheimer disease;
BMI=
body mass index;
CDR=
Clinical Dementia Rating scale;
CI=
confidence interval;
MAPT=
Multidomain Alzheimer Preventive Trial;
MCI=
mild cognitive impairment;
SUVR=
standard uptake value ratio

Footnotes

  • Coinvestigators are listed on the Neurology® Web site at Neurology.org.

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Supplemental data at Neurology.org

  • Received March 27, 2015.
  • Accepted in final form August 31, 2015.
  • © 2015 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • GLOSSARY
    • METHODS
    • RESULTS
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Disclosures
Advertisement

Topics Discussed

  • Alzheimer's disease
  • PET
  • Basal ganglia
  • Motor Control
  • MCI (mild cognitive impairment)

Alert Me

  • Alert me when eletters are published
Neurology: 96 (9)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise