Low-frequency and common genetic variation in ischemic stroke
The METASTROKE collaboration
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Article Information
- Received July 28, 2015
- Accepted in final form December 14, 2015
- First Published March 2, 2016.
Article Versions
- Previous version (March 2, 2016 - 13:00).
- You are viewing the most recent version of this article.
Author Disclosures
- Rainer Malik, PhD*,
- Matthew Traylor, PhD*,
- Sara L. Pulit, BA*,
- Steve Bevan, PhD,
- Jemma C. Hopewell, PhD,
- Elizabeth G. Holliday, PhD,
- Wei Zhao, MS,
- Patricia Abrantes, PhD,
- Philippe Amouyel, MD, PhD,
- John R. Attia, MD, PhD,
- Thomas W.K. Battey, BS,
- Klaus Berger, MD,
- Giorgio B. Boncoraglio, MD,
- Ganesh Chauhan, PhD,
- Yu-Ching Cheng, PhD,
- Wei-Min Chen, PhD,
- Robert Clarke, FRCP,
- Ioana Cotlarciuc, PhD,
- Stephanie Debette, MD, PhD,
- Guido J. Falcone, MD, ScD, MPH,
- Jose M. Ferro, MD, PhD,
- Dale M. Gamble, BS,
- Andreea Ilinca, MD,
- Steven J. Kittner, MD, MPH,
- Christina E. Kourkoulis, BS,
- Robin Lemmens, MD, PhD,
- Christopher R. Levi, MBBS, PhD,
- Peter Lichtner, PhD,
- Arne Lindgren, MD, PhD,
- Jingmin Liu, MS,
- James F. Meschia, MD,
- Braxton D. Mitchell, PhD, MPH,
- Sofia A. Oliveira, PhD,
- Joana Pera, MD, PhD,
- Alex P. Reiner, MD,
- Peter M. Rothwell, MD, PhD, FMedSci,
- Pankaj Sharma, MD, PhD,
- Agnieszka Slowik, MD, PhD,
- Cathie L.M. Sudlow, MD, PhD,
- Turgut Tatlisumak, MD, PhD,
- Vincent Thijs, MD, PhD,
- Astrid M. Vicente, PhD,
- Daniel Woo, MD,
- Sudha Seshadri, MD,
- Danish Saleheen, PhD,
- Jonathan Rosand, MD, MSc,
- Hugh S. Markus, DM,
- Bradford B. Worrall, MD, MSc,
- Martin Dichgans, MD;
- For the ISGC Analysis Group;
- For the METASTROKE collaboration;
- The Wellcome Trust Case Control Consortium 2 (WTCCC2);
- The NINDS Stroke Genetics Network (SiGN)
- Rainer Malik, PhD*,
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- Matthew Traylor, PhD*,
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- Sara L. Pulit, BA*,
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(1) Illumina, honoraria for speaking at an Illumina event at the American Society of Human Genetics (2015)
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(1) Illumina, honoraria for speaking at an Illumina event at the American Society of Human Genetics (2015) (same disclosure as above)
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- Steve Bevan, PhD,
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- Jemma C. Hopewell, PhD,
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Research grants paid to my institution from pharmaceutical companies (Merck, Abbott (Solvay), AstraZeneca, Bayer Germany, Bayer US, GlaxoSmithKline, Merck & Schering) for studies conducted, analysed and reported independently of all funding sources. The CTSU has a policy of not accepting honoraria or other payments, except for reimbursement of costs to participate in scientific meetings.
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(1) British Heart Foundation (FS/14/55/30806) (2) British Heart Foundation, Centre for Research Excellence, Oxford
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- Elizabeth G. Holliday, PhD,
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Australian National Health and Medical Research Council (NHMRC), APPID 631096, Chief Investigator, 2010-2014
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- Wei Zhao, MS,
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- Patricia Abrantes, PhD,
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(1) Funda??o Para a Ci?ncia e a Tecnologia, Portugal (Grant SFRH/BPD/35737/2007).
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- Philippe Amouyel, MD, PhD,
Alzprotect SAB, start up company Takeda
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European Journal of Prevention and Cardiac Reahabilitation Alzheimer's & Dementia
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Inserm Lille university ANR Fondation Plan Alzheimer France Alzheimer
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Genoscreen
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- John R. Attia, MD, PhD,
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Chapter on Genetic association studies in UpToDate.
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Peer-reviewed project grant from the National Health and Medical Research Council (Australian government)from 2014-2018.
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- Thomas W.K. Battey, BS,
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- Klaus Berger, MD,
Non-profit organisation: Member of the Scientific Advisory Board of the Swiss Paraplegic Research Organisation <1000 $
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1) For the conduction of an epidemiologic study on migraine unrestricted research grants of equal share from Allmiral, Astra-Zeneca, Berlin-Chemie, Boehringer Ingelheim Pharma, Boots Healthcare, GlaxoSmithKline, Janssen Cilag, McNeil Pharmaceuticals, MSD Sharp & Dohme, Pfizer, PI, 2003-2006 2)For the conduction of an epidemiologic study on RLS unrestricted research grants from Boehringer Ingelheim Pharma, Mundipharma Research, Neurobiotec, UCB Germany, UCB Switzerland, Vifor Pharma, Roche Pharma (2008-2011 and 2011-2014)
1)German Ministry of Research + Education (BMBF), 01ER0816, PI, 2009-2014 2)German Ministry of Research + Education (BMBF), 01GI0814, Co-PI, 2009-2011 3)German Ministry of Research + Education (BMBF), 01ET0723, Co-PI, 2008-2010 4) German Ministry of Research + Education (BMBF), 01GI0438, PI, 2006-2008 2)German Ministry of Research + Education (BMBF), 01GI0814, Co-PI, 2009-2011
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1) For the conduction of an epidemiologic study on migraine unrestricted research grant from the German Migraine & Headache Society, PI, 2003-2006 2) For the conduction of an epidemiologic study on RLS unrestricted research grant from the German RLS Foundation, PI, 2007-2010 3) Hannelore-Kohl-Foundation, Data analyst, 2009
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- Giorgio B. Boncoraglio, MD,
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- Ganesh Chauhan, PhD,
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- Yu-Ching Cheng, PhD,
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Department of Veterans Affairs Career Development Award, (1IK2BX001823), PI, 2 years
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- Wei-Min Chen, PhD,
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- Robert Clarke, FRCP,
It is CTSU policy to decline personal compensation from any source for publications or lectures or any pharmaceutical company. While I am a member of several Scientific Advisory Boards (CARDIOGRAMplusC4D, METASTROKE, BEST-D), I have not received any payments for these roles.
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PlosONE (no payment)
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1)BHF (2012-2014) Vitamin D supplementation and markers of inflammation, immunity and arterial stiffness R Clarke, J Armitage, J Knight, J Tomson ?112K 2) BHF (2009-2017) Research Excellence Award R Collins, H Watkins*, Z Chen, R Clarke, SC Darby?8.4M shared; 3) BHF (2008-2013)Direct support for trials and epidemiological studies.R Collins, R Clarke, L Bowman, M Landray ?2.6M; 4) BHF (2012-2014);Effect of vitamin D on cardiac contractile function R Clarke, J Tomson, J Armitage ?40k MRC (2008-2013) Direct support for large epidemiological studies and collaborative overviews R Collins, R Peto, C Baigent, J Armitage, Z Chen, R Clarke ?13.8M; 5) MRC (2013-2016) Genomic and metabolomic analysis of haemorrhagic stroke in the China Kadoorie Biobank Z Chen, M Ala-Korpela*, R Clarke, Rory Collins, P Donnelly*, M Hill, L Li*, I Millwood, R Peto, C Sudlow*, R Walters ?1.3M.
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- Ioana Cotlarciuc, PhD,
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- Stephanie Debette, MD, PhD,
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Editorial board of Stroke
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French National Research Agency (ANR, Vascogene [PI]; JPND, BRIDGET [PI]) European Union (ERC starting grant SEWGAY [PI]; H2020 Costream [partner])
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Leducq Foundation (member of grant on small artery disease pathophysiology)
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- Guido J. Falcone, MD, ScD, MPH,
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- Jose M. Ferro, MD, PhD,
Advisory Board - Boehringer Ingelheim (BI) (2014-ongoing)
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Serve as an editorial board member of Cerebrovascular Diseases and Stroke (1991-present)
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Royalties from
Received honoraria from BI for a lecture (2014)
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- Dale M. Gamble, BS,
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- Andreea Ilinca, MD,
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(1)Lundbeck AB, Sweden, funding for travel to conference (2)Medtronic AB, Sweden, lecturing fee (
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Swedish Board of National Health and Welfare for contributions to National Treatment Guidelines for Parkinson Disease (
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(1)Region Sk?ne, Sweden (2)Lund University, Sweden (3)Sk?ne University Hospital, Sweden (4)The Swedish Parkinson Foundation (Parkinsonfonden; to
Bundy Academy, Sweden (
(1)The Swedish Heart-Lung Foundation, Sweden (2)King Gustaf V and Queen Victoria Foundation, Sweden (3)The Swedish Stroke Association, Sweden (4)The Freemasons Lodge of Instruction EOS in Lund (5)The Swedish Parkinson Academy (
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- Steven J. Kittner, MD, MPH,
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Editorial Board, Neuroepidemiology, 2000- present
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NINDS: 1U01NS069208, Co-PI, 2010-2016 NINDS: R01NS069763-01, Site PI
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Atlantic States Insurance, Review of Medical Case, 2013
- Christina E. Kourkoulis, BS,
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- Robin Lemmens, MD, PhD,
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- Christopher R. Levi, MBBS, PhD,
Apixaban Scientific Advisory Board - Pfizer National Stroke Foundation (Australia) Research Advisory Committee
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Received travel expenses and/or honoraira for lectures or educational activities not funded by industry
Advisory Board - Medicine Today, Since 2009 Associate Editor - BMC Neurology, Since 2011
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Expert External Reviewer - Stroke and Neurology Service, The Alfred Hospital, Melbourne. 2012
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NHMRC Practitioner Fellowship 2013-17 NHMRC Project and Partnership Grants 2000-2017 Australian Brain Foundation Project Grants
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National Stroke Foundation, Australia
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- Peter Lichtner, PhD,
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- Arne Lindgren, MD, PhD,
(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer (6)Bayer
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(1)Astra Zeneca (2)Bristol-Myers Squibb (3)Boehringer Ingelheim (4)Sanofi (5)Pfizer (6)Bayer
(1) Neurologi i Sverige. 2011-2014. Editorial advisory board member.
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- Jingmin Liu, MS,
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- James F. Meschia, MD,
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On the editorial boards of Mayo Clinic Proceedings, Stroke, and the European Journal of Neurology.
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Dr. Meschia receives support from the NINDS for efforts devoted to the SiGN study.
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- Braxton D. Mitchell, PhD, MPH,
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Diabetes, Associate Editor, 2009 - Diabetes/Metabolism Research and Reviews (Co-Editor, 2002-2014) Diabetes Management (Editorial Advisory board, 2011-2014)
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1. NIH P30DK072488,Co-Director, 2011 - 2019 2. NIH U01NS069208, Co-Investigator, 2010 - 2015 3. NIH R01NS073346, Co-Investigator, 2011 ? 2015
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- Sofia A. Oliveira, PhD,
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? ?Glucocerebrosidase in Parkinson?s disease: from risk factor to biomarker? Fundacao para a Ciencia e a Tecnologia Grant PTDC/DTP- PIC/0904/2012 (Participant: Oliveira SA, 2013-2015) ? ?Patients as health care innovators: An empirical investigation of treatment, therapies and medical devices (TT&MD) developed by patients of chronic diseases? Fundacao para a Ciencia e a Tecnologia Grant PTDC/IIM-GES/5015/2012 (Participant: Oliveira SA, 2013-2015) ? ?Technology, Entrepreneurship and Innovation Policy Lab? Fundacao para a Ciencia e a Tecnologia Grant CMUP-ERI/TPE/0028/2013 (Participant: Oliveira SA, 2014-2018)
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- Joana Pera, MD, PhD,
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- Alex P. Reiner, MD,
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- Peter M. Rothwell, MD, PhD, FMedSci,
Bayer - Executive Committee of ARRIVE Trial - 2006 onwards Servier - Executive Committee of PERFORM trial - 2005 -2010 Pfizer - IDMC if Rocket-AF Trial - 2006 - 2009 Biotronic - Executive Committee of device trial - 2005 - 2011
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I don't keep a record. Certainly had travel expenses paid by Sanofi-Aventis, Servier, Astra-Zeneca and Bayer in past. However, nothing relevant to this manuscript.
Editorial Board - Lancet Neurology, International Journal of Stroke
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- Pankaj Sharma, MD, PhD,
Bohringer 2009 & 2013 advisory board member 2013-14 Bayer advisory board member
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J Royal Soc Medicine Cardiovascular Disease Editor in Chief
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- Agnieszka Slowik, MD, PhD,
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- Cathie L.M. Sudlow, MD, PhD,
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(1) UK MRC, UK Biobank programme renewal, ?35 million, 2010-2017 (co-applicant) (2) UK MRC, Dementias Platform UK programme grant, ?12 million, 2014-2019 (co-applicant)
(1) British Heart Foundation 2012-2017 RESTART trial of antiplatelet treatment in ICH ( co- applicant) (2) UKBiobank 01/05/2012-ongoing Stroke Outcomes Pilot (principal applicant) (3) UK Biobank 01/09/2012-ongoing chief scientist support (principal applicant) (4) NIH via University of Maryland Stroke GWAS sub award for stroke phenotyping 01/06/2011-31/12/2013
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- Turgut Tatlisumak, MD, PhD,
Boehringer-Ingelheim Mitsubishi Pharma BrainsGate H. Lundbeck A/S Bayer Pfizer
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Professio Finland (speaker honoraria) Genzyme Oy (Finland, speaker honoraria) Congress traveling and accommodation costs: European Stroke Conference European Federation of Neurological Societies European Stroke Organisation L?ANTEL telemedicine conference (France) University of Rostock (Germany) University of Bielefeld (Germany) SITS International Boehringer Ingelheim University of Donau (Austria) Catholic University of Leuven (Belgium) Austrian Stroke Society University of Oulu (Finland) Nordic Stroke Conference Australia-NZ Stroke Association Polish Neuroscience Socitey Internal Medicine Society of Greece World Stroke Conference Thrombolysis and Thrombectomy in Acute Stroke Treatment Conference University of Tarto University of Tuebingen German Psychological Society
Stroke, 2000-2006, 2010- Current Vascular Pharmacology, 2002- Stroke Research and Treatment, 2009- BMC Journal of Experimental and Translational Stroke Medicine, 2009-2015 Frontiers in Stroke, 2010- Case Reports in Neurology (founding editor-in-chief)2009- 2012 Cerebrovascular Diseases, 2011-2014 No compensation was received for any of the above editorial duties
1. Stanniocalcin proteins and nucleic acids and methods based thereon. Application No/ Patent No: WO0130969, Publication date: 2001-05-03, requested patent: EP1233778, Inventors: Olsen HS, Zhang K, Lindsberg P, Tatlisumak T, Kaste M, Andersson LC. Human Genome Sciences Inc (US), Application number: WO2000US29432 200001026 2. New Therapeutic Uses (method to prevent brain edema and reperfusion injury), PCT/FI2004/000070. Inventors: Lindsberg PJ, Karjalainen-Lindsberg M-L, Tatlisumak T, Strbian D. Applicant: Licentia Oy. Application date: February 13, 2003. Publication 7/2003, Application number: 20030224. 3. Thrombolytic compositions (method to prevent postthrombolytic hemorrhage formation), PCT/FI2004/000071. Inventors: Lindsberg PJ, Karjalainen- Lindsberg M-L, Tatlisumak T, Strbian D, Kovanen P. Applicant: Licentia Oy. Application date: February 13, 2003. Publication: 3/2003. Application number: 20030225.
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Boehringer Ingelheim, BrainsGate, H. Lundbeck A/S, Bayer, Pfizer
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Helsinki University Central Hospital Research Funds, PI European Union, EU FP7 202213, 2008-2012, PI Biocentrum Finland, 2010-2012 Biocentrum Helsinki, 2011, 2012, 2013, PI Finnish Academy of Sciences, 2012-2014, PI National Institutes of Health University of Gothenburg Research Funds, PI Sahlgrenska University Hospital Reserach Funds, PI
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Sigrid Juselius Foundation, 2010,2014, and 2015 PI Maire Taponen Foundation, 2012 and 2014 Liv och H?lsa 2012
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- Vincent Thijs, MD, PhD,
(1)Sygnis Ax200 steering committee (2) Boehringer Ingelheim Belgium advisory board (3) Boehringer Ingelheim international advisory board (4) Medtronic steering committee of the REACT-AF trial
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(1) Medtronic (2) Boehringer Ingelheim (3) Pfizer (4) Bayer
Acta Neurologica Belgica, Associate Editor, ongoing Stroke Editorial board member, ongoing European Journal of Emergency Medicine, Editorial Board member, ongoing
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(1) Boehringer Ingelheim (2) Pfizer (3) Bayer (4) Astra Zeneca (5) Medtronic
Pfizer Inc Boehringer Ingelheim Medtronic
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SYGNIS AG, Medtronic, Inc., Pfizer Inc., AstraZeneca, Boehringer Ingelheim, Astra Zeneca
VIB Flanders Research Fund (FWO)
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Flanders Research Fund (FWO)
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- Astrid M. Vicente, PhD,
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Autism Spectrum Disorder in Europe (ASDEU). Funded by the Directorate-General of Health and Consumers of the European Commission (DG-SANCO) (Partner). 2015-2018 Joint Action on Chronic Disorders (CHRODIS-JA). Funded by the Health Programme of the European Union (Associated partner). 2014-2017 Identifying the early signs of Autism Spectrum Disorder - integration of behavioral and genetic information for early autism detection in an at-risk population. Funded by Funda??o para a Ci?ncia e Tecnologia,Portugal, PTDC/SAU- SAP/119161/2010 (Principal Investigator). 2012-2015.
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- Daniel Woo, MD,
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(1) Stroke Research and Treatment, Associate Editor, 2010-2014.
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NIH Funding: NS36695 (PI: 1998-Current); NS30678 (CoI: 1998-Current). NS69763 (PI: 2010-Current).
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- Sudha Seshadri, MD,
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Journal of Alzheimer's Disease, Associate Editor since 2005. Stroke: Editorial Board since 2010. Neurology: Editorial Board since 2011.
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NIA AG008122, AG033040, AG049505, AG033193, AG049607
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- Danish Saleheen, PhD,
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- Jonathan Rosand, MD, MSc,
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Lancet Neurology, editorial board member Stroke, editorial board member
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Boehringer Ingelheim
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NINDS, R01NS059727 NINDS, R01NS073344 NINDS, U01NS069208 NINDS, U01NS069763
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Boehringer Ingelheim, consultant
- Hugh S. Markus, DM,
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Section editor International Journal of stroke editorial board Clin Neurology and Neurosurgery and BMC Medicine
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Stroke Medicine OUP. 2010
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Wellcome Trust the WTCCC2 study
Stroke Association, EU, Wellcome Trust, The British Heart Foundation, Alzheimer Research for peer reviewed research grants
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- Bradford B. Worrall, MD, MSc,
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Neurology: Associate Editor 1 July 2009 - September 2015; Deputy Editor October 2015 - present Seminars in Neurology Editorial Board 2006-2014
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Chapter Author for Merritt's Neurology editions 10, 11, and 12.
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NINDS/NIH - R01 NS 069763 (co-investigator) 2010-2016 NINDS/NIH ? U-01 NS069208 (co-Prinicpal Investigator) 2010-2015 NHGRI/NIH ? U-01 HG005160 (co-Principal Investigator) 2009-2014
University of Virginia - CENETERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Principal Investigator 10/13-9/15
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- Martin Dichgans, MD;
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(1) Bayer Vital, (2) Boehringer Ingelheim, (3) Bristol- Meyer Squibb, (4) Daiichi Sankyo
(1) Stroke the International Journal of Stroke, editor, (2) Cerebrovascular diseases, editorial board member, (3) Journal of Neurochemistry, editor
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(1) Bayer Vital, (2) Boehringer Ingelheim, (3) Bristol- Meyer Squibb, (4) Daiichi Sankyo
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(1) Wellcometrust, 03/08 following, (2) European Union (EU FP 7), investigator, 10/13-09/16, (3) German Federal Ministry of Education and Research (BMBF), investigator, 12/13-11/16, (4) European Union (EU FP 6), investigator, 03/12-02/15
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(1) Vascular Dementia Research Foundation, (2) Corona Foundation
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- For the ISGC Analysis Group;
- For the METASTROKE collaboration;
- The Wellcome Trust Case Control Consortium 2 (WTCCC2);
- The NINDS Stroke Genetics Network (SiGN)
- Correspondence to Dr. Dichgans: martin.dichgans{at}med.uni-muenchen.de
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