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Abstract
Objective: To investigate bone resorption and formation markers as well as bone mineral density in women with restless legs syndrome (RLS).
Methods: This was a prospective cross-sectional case-control study involving drug-naive women with RLS and age- and body mass index (BMI)–matched female controls. Routine blood analyses, markers of bone formation, procollagen 1 n-terminal peptide, bone resorption, c-telopeptide of type 1 collagen (CTX), sclerostin, and bone mineral density (BMD) were compared between the 2 groups. Pregnant or breastfeeding women and individuals with comorbidities other than iron deficiency, type 2 diabetes mellitus, or hypertension were excluded.
Results: A significant increase in lumbar BMD was found among 78 women with RLS as compared to 78 age- and BMI-matched controls (p = 0.001). The proportion of patients with osteopenia as defined by a lumbar T score was significantly lower among patients with RLS (p = 0.040). CTX and sclerostin were significantly lower in patients with RLS (p = 0.006 and p = 0.011, respectively), as were the levels of 25-hydroxy vitamin D3, calcemia, and free T3 (p = 0.017, p = 0.017, and p = 0.002, respectively).
Conclusions: Despite lower 25-hydroxy vitamin D3, patients with RLS had lower bone resorption markers, higher lumbar BMD, and lower frequency of lumbar osteopenia. As patients with RLS make movements night and day to decrease the severity of their symptoms, they unconsciously perform exercise, which may potentially explain the better bone profile among patients with RLS than in controls.
GLOSSARY
- BMD=
- bone mineral density;
- BMI=
- body mass index;
- CBC=
- complete blood count;
- CTX=
- C-telopeptide of type 1 collagen;
- IRLSSG=
- International Restless Legs Syndrome Study Group;
- PINP=
- procollagen 1 N-terminal peptide;
- RLS=
- restless legs syndrome
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Editorial, page 1179
- Received July 20, 2015.
- Accepted in final form November 25, 2015.
- © 2016 American Academy of Neurology
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Disputes & Debates: Rapid online correspondence
- Author Response to Liguori et al.
- Increased bone mineral density after Restless legs syndrome dopaminergic-treatment
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