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April 05, 2016; 86 (16 Supplement) April 18, 2016

Military Personnel with Traumatic Stress Show Changes in Large-Scale Brain Networks after Use of a Closed-Loop Neurotechnology (I7.009)

Charles Tegeler, Catherine Tegeler, Jared Cook, Sung Lee, Hossam Shaltout, Paul Laurienti
First published April 4, 2016,
Charles Tegeler
3Wake Forest School of Medicine Winston Salem NC United States
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Catherine Tegeler
2Wake Forest Sch of Med, Neurology Winston Salem NC United States
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Jared Cook
4Neurology Wake Forest School of Medicine Winston-Salem NC United States
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Sung Lee
1Brain State Technologies, LLC Scottsdale AZ United States
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Hossam Shaltout
5Obstetrics and Gynecology, Hypertension and Vascular Research Center Wake Forest School of Medicine Winston Salem NC United States
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Paul Laurienti
6Radiology Wake Forest School of Medicine Winston Salem NC United States
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Citation
Military Personnel with Traumatic Stress Show Changes in Large-Scale Brain Networks after Use of a Closed-Loop Neurotechnology (I7.009)
Charles Tegeler, Catherine Tegeler, Jared Cook, Sung Lee, Hossam Shaltout, Paul Laurienti
Neurology Apr 2016, 86 (16 Supplement) I7.009;

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Abstract

Objective: Evaluate changes in network connectivity on fMRI associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM®), among subjects enrolled in a pilot study for symptoms of military-related traumatic stress (MTS). Background: Traumatic stress is a major concern in military populations. HIRREM is a closed-loop acoustic stimulation technology that identifies dominant brain frequencies and translates them in real time into audible tones of variable pitch and timing, to support self-optimization of brain activity. We report interim pre and post-HIRREM fMRI results in 12 subjects with symptoms of MTS. Methods: Twelve male service members (10) or Veterans (2), median age 43.5 (29-50), with symptoms of MTS lasting from 2-12 years, received 20 (17-21) HIRREM sessions over 12 days. Outcomes included resting brain MRI for network connectivity analysis. Results: Interim network analysis was performed on whole-brain, resting MRI data, with a focus on the Central Executive Network (CEN), Salience Network (SN), and Default Mode Network (DMN), community structure. Intervention-related trends are seen in all networks. Overall the DMN had the highest consistency across the group for the three sub-networks, and also exhibited intervention-related reductions in frontal connectivity and increases in posterior connectivity. The CEN showed an overall increase in connectivity throughout the network following the intervention. The SN exhibited substantial increases in the connectivity to the frontal lobes and reduced connectivity to insula. A permutation statistic showed statistical trends for changes in all three networks (DMN, p = 0.11, CEN, p = 0.059, and SN, p = 0.14). Conclusions: These interim results suggest substantial shifts in connectivity across three key large-scale brain networks associated with the use of HIRREM. Confirmation of these findings in this, and future studies, may provide important insights into functional changes associated with beneficial effects of HIRREM, as well as functional disturbances underlying MTS.

Disclosure: Dr. Tegeler has nothing to disclose. Dr. Tegeler has nothing to disclose. Dr. Cook has nothing to disclose. Dr. Lee has received personal compensation for with activities with Brain State Technologies, LLC., as an employee. Dr. Shaltout has nothing to disclose. Dr. Laurienti has nothing to disclose.

Monday, April 18 2016, 1:00 pm-5:30 pm

  • Copyright © 2016 by AAN Enterprises, Inc.

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