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October 18, 2016; 87 (16) Article

Calcium supplementation and risk of dementia in women with cerebrovascular disease

Jürgen Kern, Silke Kern, Kaj Blennow, Henrik Zetterberg, Margda Waern, Xinxin Guo, Anne Börjesson-Hanson, Ingmar Skoog, Svante Östling
First published August 17, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003111
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Article Information

vol. 87 no. 16 1674-1680
DOI: 
https://doi.org/10.1212/WNL.0000000000003111
PubMed: 
27534711
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 16, 2016
  • Accepted in final form July 5, 2016
  • First Published August 17, 2016.

Article Versions

Copyright & Usage: 
© 2016 American Academy of Neurology

Author Disclosures

    1. Jürgen Kern, MD, PhD*,
    2. Silke Kern, MD, PhD*,
    3. Kaj Blennow, MD, PhD,
    4. Henrik Zetterberg, MD, PhD,
    5. Margda Waern, MD, PhD,
    6. Xinxin Guo, MD, PhD,
    7. Anne Börjesson-Hanson, MD, PhD,
    8. Ingmar Skoog, MD, PhD‡ and
    9. Svante Östling, MD, PhD‡
  1. Jürgen Kern, MD, PhD*,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Silke Kern, MD, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor of Journal of Alzheimer's disease since 2016 without compensation.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Kaj Blennow, MD, PhD,
    4. Scientific Advisory Boards:

    1. Dr Blennow has served at advisory boards or as a consultant for Eli Lilly, IBL International, and Roche Diagnostics.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Fujirebio Europe

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Novartis

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The Research Council, Sweden (project # 14002) and LUA/ALF project, V?stra G?talandsregionen, Sweden (project # ALFGBG-11019)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Torsten S?derberg Foundation at the royal Swedish Academy of Sciences, the Alzheimer Foundation, Sweden, the Stiftelsen f?r Gamla Tj?narinnor, Stockholm, Sweden and Hj?rnfonden, Sweden.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Henrik Zetterberg, MD, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer's Disease, Associate Editor Alzheimer's & Dementia, Associate Editor DADM, Associate Senior Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. HZ is co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) The Swedish Research Council (K2010-63P-21562-01-4, K2011-61X-20401-05-6); (2) Swedish State Support for Clinical Research (ALFGBG-144341); (3) VINNOVA; (4) the Knut and Alice Wallenberg Foundation; (5) the European Research Council; and (6) Frimurarestiftelsen

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Margda Waern, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Den suicidn?ra patienten (The suicidal patient). Studentlitteratur. receipt of royalties 2012-2016.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Swedish Council for working life and social research Suicidal thoughts and attempts in women followed from mid- to late life. Grant number 2012-1138. PI. 2013-2014. Suicidality in suicide attempters. Swedish Research Council. grant number 2013-2699. PI 2014-2016. Suicidality in older women. King Gustaf V and Queen Victoria's Freemason Foundation. 2014-16. SCREAM: Acute suicidal episodes. Gothenburg Center for Person-centered Care. 2014. Suicidality in suicide attempters. Swedish Research Council. grant number 2011-299. PI 2012-2014. Sahlgrenska Studies on suicide. Swedish Research Council. grant number 2008-3139 Swedish Council for working life and social research A 41 year longitudinal population study on dementia and other disorders in women. Grant number 2008-1229.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Xinxin Guo, MD, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Anne Börjesson-Hanson, MD, PhD,
    8. Scientific Advisory Boards:

    1. Served on advisory board or DSMB for Kyowa Hakko Kirin and Ionis

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant for Pfizer, Janssen-Cilag, Lundbeck, Novartis

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. Serve as investigator for clinical trials sponsored by Lilly, Novartis, Pfizer, ACImmune, Sanofiaentis

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Ingmar Skoog, MD, PhD‡ and
    9. Scientific Advisory Boards:

    1. Takeda

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Takeda Novartis

    Editorial Boards:

    1. American Journal of Geriatric psychiatry. Triage-Editor 2010- European Journal of Psychiatry. Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. Dementia textbook Sweden 2003. Liber Text book in acute psychiatri. Studentlitteratur

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Takeda

    Speakers' Bureaus:

    1. Takeda

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)The Swedish Research Council 11267, 825-2012-5041, 2013-8717, 2015-02830 PI 1994 until now (2) Swedish Research Council for Health, Working Life and Wellfare (2012-1138, 2013-1202, 2013-2300, 2013-2496, 2006-1506)PI, 1999 until now (3) Swedish Brain Power co-PI, 2005 until now

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Alzheimer's Association Zenith Award (ZEN-01-3151) The Alzheimer's Association Stephanie B. Overstreet Scholars (IIRG-00-2159) The Alzheimer's Association (IIRG-03-6168) The Bank of Sweden Tercentenary Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Svante Östling, MD, PhD‡
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. FAS 2013-0475 1.500.000 swedish kr

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 220.000 swedish kr. S?derstr?m K?nigska projektanslag

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neuropsychiatric Epidemiology (J.K., S.K., M.W., X.G., A.B.-H., I.S., S.O.) and Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology (S.K., K.B., H.Z.), Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and UCL Institute of Neurology (H.Z.), London, UK.
  1. Correspondence to Dr. S. Kern: silke.kern{at}neuro.gu.se
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Cited By...

Letters: Rapid online correspondence

  • Author response to Dr. Beale
    • Silke Kern, MD, PhD, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska A
    • J. Kern; K. Blennow; H. Zetterberg; M. Waern; X. Guo; A. B?rjesson-Hanson; I. Skoog; S. ?stling
    Submitted October 28, 2016
  • Methodology leads to unreliable results
    • David J. Beale, Clinical Pharmacist, CVS Health
    Submitted October 21, 2016
  • Author Response to Dr. Rosenberg
    • Silke Kern, MD, PhD, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska A
    • J. Kern, K. Blennow, H. Zetterberg, M. Waern, X. Guo, A. Borjesson-Hanson, I. Skoog, S. Ostling
    Submitted September 28, 2016
  • Calcium-associated dementia risk
    • Gilad Rosenberg, Medical Director, Clal Biotechnology Industries
    Submitted September 23, 2016
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