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October 18, 2016; 87 (16) Article

Thyroid function and the risk of dementia

The Rotterdam Study

Layal Chaker, Frank J. Wolters, Daniel Bos, Tim I.M. Korevaar, Albert Hofman, Aad van der Lugt, Peter J. Koudstaal, Oscar H. Franco, Abbas Dehghan, Meike W. Vernooij, Robin P. Peeters, M. Arfan Ikram
First published September 16, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003227
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Article Information

vol. 87 no. 16 1688-1695
DOI: 
https://doi.org/10.1212/WNL.0000000000003227
PubMed: 
27638924
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 3, 2016
  • Accepted in final form July 5, 2016
  • First Published September 16, 2016.

Article Versions

Copyright & Usage: 
© 2016 American Academy of Neurology

Author Disclosures

    1. Layal Chaker, MD,
    2. Frank J. Wolters, MD,
    3. Daniel Bos, MD, PhD,
    4. Tim I.M. Korevaar, MD,
    5. Albert Hofman, MD, PhD,
    6. Aad van der Lugt, MD, PhD,
    7. Peter J. Koudstaal, MD, PhD,
    8. Oscar H. Franco, MD, PhD,
    9. Abbas Dehghan, MD, PhD,
    10. Meike W. Vernooij, MD, PhD,
    11. Robin P. Peeters, MD, PhD and
    12. M. Arfan Ikram, MD, PhD
  1. Layal Chaker, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Frank J. Wolters, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Dutch Heart Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Daniel Bos, MD, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Tim I.M. Korevaar, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Albert Hofman, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editor Eur J Epidemiol from 2000 onwards

    Patents:

    1. NONE

    Publishing Royalties:

    1. Royalties two Dutch books on epidemiology: Grondslagen der Epidemiologie, Elsevier 2008 Klinische Epidemiologie Elsevier 2000 Investigating neurological disease, Cambridge University press 1996

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Aad van der Lugt, MD, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. GE Healthcare travel /speaker honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. My institution (Erasmus MC) has received unrestricted grants from AngioCare BV, Medtronic/Covidien/EV3?, MEDAC Gmbh/LAMEPRO, Penumbra Inc., Stryker?, and Top Medical/Concentric for the MR CLEAN study. My institution has received research support from GE Healthcare

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Dutch Heart Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Peter J. Koudstaal, MD, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Neurologie. Reed Elsevier. 2006

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Oscar H. Franco, MD, PhD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. BMC publich health associate editor since January 2012 European Journal of Epidemiology associate editor since January 2014

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Dr. Oscar H. Franco works in ErasmusAGE, a centre for ageing research across the life course funded by Nestl? Nutrition (Nestec Ltd.), Metagenics Inc. and AXA. Nestl? Nutrition (Nestec Ltd.), Metagenics Inc. and AXA had no role in design and conduct of the study and preparation, review or approval of the manuscript.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Pfizer nutrition, Nestle, Metagenics

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Abbas Dehghan, MD, PhD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Abbas Dehghan has received travel honoraria from Metagenics Inc. (outside the scope of submitted work).

    Editorial Boards:

    1. BMC cardiovascular disorders, associate editor, 2011

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Abbas Dehghan has received consultancy from Metagenics Inc. (outside the scope of submitted work).

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Meike W. Vernooij, MD, PhD,
    11. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) research fellowship from the Erasmus MC University Medical Center, Rotterdam, the Netherlands (2) a Netherlands Organization of Scientific Research (NWO)/ZonMW clinical fellowship (90700435)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Robin P. Peeters, MD, PhD and
    12. Scientific Advisory Boards:

    1. Scientific Advisory Board of 2 commercial entities: - Genzyme Europe Bv - EISAI

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Lecture fees from commercial entities: - Genzyme - Ipsen - GoodLife Fertility BV

    Editorial Boards:

    1. Editorial Board memberships: * Editorial board of Mol Cell Endocrinol (IF: 4.219) (2014-present) * Editorial Board of the Journal of Endocrinological investigation (IF: 1.448) (2013-present) * Editorial Board of three new scientific journals (European Thyroid Journal, Frontiers in Thyroid Endocrinology and Frontiers in Cancer Endocrinology) (2011-present)

    Patents:

    1. The invention involves a pre-pregnancy test to predict thyroid disease during pregnancy

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Veracyte

    Research Support, Government Entities:

    1. - ZonMW TOP Grant (nr. 40-00812-98-12044): (unraveling clinical syndrome of TH resistance0 - ZonMW Clinical Fellowship (nr. 90700412): (thyroid and pregnancy) - ZonMW Priorities Medicine Rare Disease (nr: 40-41900-98- 248): (triac as a treatment for patients with a defect in thyroid hormone transporter MCT8)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. - Sherman Foundation (Triac Trial goes global; 2015): (triac as a treatment for patients with a defect in thyroid hormone transporter MCT8)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  12. M. Arfan Ikram, MD, PhD
    13. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Kaizo ltd, speaker honorarium

    Editorial Boards:

    1. (1) Neuroepidemiology, Editorial Board Member, 2011-2016, (2) PLoS One, Academic Editor, 2013-2016, (3) Journal of Alzheimer Disease, Academic Editor, 2016

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Janssen Prevention Center

    Research Support, Government Entities:

    1. (1) Netherlands Organization for Health Research and Development, ZonMW: 916.13.054, PI, 2012-2016, (2) European Research Council, PI, 2016-2020, (3) Joint Programme in Neurodegenerative Diseases, PI, 2014-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) the Netherlands Heart Foundation (2009B102 and 2012T008), (2) Internationaal Parkinson Fonds, (3) Internationale Stichting Alzheimer Onderzoek (#12533), (4) Alzheimer Association, (5) Alzheimer Nederland, (6) Institute for Scientific Information on Coffee

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Rotterdam Thyroid Center (L.C., T.I.M.K., R.P.P.) and Departments of Internal Medicine (L.C., T.I.M.K., R.P.P.), Epidemiology (L.C., F.J.W., D.B., T.I.M.K., A.H., O.H.F., A.D., M.W.V., R.P.P., M.A.I.), Neurology (F.J.W., P.J.K., M.A.I.), and Radiology (D.B., A.v.d.L., M.W.V., M.A.I.), Erasmus University Medical Center, Rotterdam, the Netherlands; and Department of Epidemiology (A.H.), Harvard T.H. Chan School of Public Health, Boston, MA.
  1. Correspondence to Dr. Peeters: r.peeters{at}erasmusmc.nl
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