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July 12, 2016; 87 (2) Article

Autism and epilepsy

A population-based nationwide cohort study

Heléne E.K. Sundelin, Henrik Larsson, Paul Lichtenstein, Catarina Almqvist, Christina M. Hultman, Torbjörn Tomson, Jonas F. Ludvigsson
First published June 15, 2016, DOI: https://doi.org/10.1212/WNL.0000000000002836
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Article Information

vol. 87 no. 2 192-197
DOI: 
https://doi.org/10.1212/WNL.0000000000002836
PubMed: 
27306624
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received October 22, 2015
  • Accepted in final form March 3, 2016
  • First Published June 15, 2016.

Article Versions

Copyright & Usage: 
© 2016 American Academy of Neurology

Author Disclosures

    1. Heléne E.K. Sundelin, MD,
    2. Henrik Larsson, PhD,
    3. Paul Lichtenstein, PhD,
    4. Catarina Almqvist, PhD,
    5. Christina M. Hultman, PhD,
    6. Torbjörn Tomson, PhD and
    7. Jonas F. Ludvigsson, PhD
  1. Heléne E.K. Sundelin, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Cyberonics. Travel to expertmeeting 2015.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Henrik Larsson, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Dr. Larsson has served as a speaker for Eli-Lilly and Shire (both outside the submitted work).

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Paul Lichtenstein, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The Swedish Foundation for international Cooperation in Research and Higher Education (STINT): IG2012-5056: 27/06/13 to 31/12/17. Institutional Grant: Genes, environments, and the development of mental health problems Role: PI Swedish Council for Working life & Social Research: 2012-1678: 01/01/13 to 12/31/18 Programme Grant: Genes, environments and the development of mental health and behavior problems from childhood to adulthood. Support for research on development of mental health problems from childhood to adulthood in twins and families. Role:PI Swedish Research Council: 2011-2492: 01/01/12-12/31/16 Genes, environments and the development of mental health and behavior problems from childhood to adulthood Role: PI European Commission: 602768: 06/01/14-05/31/20 ACTION - Aggression in Children: Unraveling gene-environment interplay to inform Treatment and Intervention strategy Role: Partner Swedish Council for Working life and Social Research: 2014-0834: 01/01/15 to 12/31/17 Identifying environmental and genetic risks for the developmental of childhood mental health problems using a large, longitudinal and genotyped twin sample: The CATSS study. Collection of longitudinal data on psychopathology and well-being from twins and their parents at age 15. Role: PI National Institute of Health (U.S): 2 R01 HD056354-04A1: 06/01/11 to 05/31/14 Twin Studies of Marriage Benefit: Parsing Selection from Causation Role: Co-PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Catarina Almqvist, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Clinical and Experimental Allergy, associate editor, 2009-2014 (2) Acta Paediatrica, editorial committee, 2012-ongoing

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Alm J, Almqvist C, Emenius. Milj?ns betydelse f?r allergi och astma. Astma och allergi hos barn Studentlitteratur, 2014.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Swedish Research Council SIMSAM framework grant no 340-2013-5867, PI, 2014-2018

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Christina M. Hultman, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Torbjörn Tomson, PhD and
    7. Scientific Advisory Boards:

    1. UCB Pharma and Eisai, honorarium to my department

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) UCB, speaker honorarium (paid to department); (2) Eisai, Inc., speaker honorarium (paid to department)

    Editorial Boards:

    1. (1) Epilepsia, Associate Editor, 2008-2013; (2) Epilepsy Research, Editorial Board, 2007-2015; (3) Epileptic Disorders, Associate Editor, 2013-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. As chair of the central project commission of EURAP, an international antiepileptic drugs and pregnancy registry, I have on behalf of the project received research grants from Bial, Eisai, GlaxoSmithKline, Novartis, and UCB annually the past two yearsGlaxoSmithKline research support for case-control study of SUDEP

    Research Support, Government Entities:

    1. (1) ALF (Stockholm County Council) 2009-2016

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) CURE, 2010, 2015

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Jonas F. Ludvigsson, PhD
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. European Journal of Epidemiology [roughly 2013-] Alimentary Pharmacology Therapeutics [roughly 2012-]

    Patents:

    1. NONE

    Publishing Royalties:

    1. Only Swedish publishers: Books related to either pediatrics or epidemiology: 1. att b?rja forksa (Studentlitteratur), 2015 2. akutpediatrik (Liber), 2010 3. barnmedicin i ett n?tskal (Studentlitteratur), 2004

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Pediatrics (H.E.K.S.), University Hospital, Linköping; Departments of Medical Epidemiology and Biostatistics (H.L., P.L., C.A., C.M.H., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), University Hospital, Örebro, Sweden; and Division of Epidemiology and Public Health (J.F.L.), School of Medicine, University of Nottingham, UK.
  1. Correspondence to Dr. Sundelin: helene.sundelin{at}hotmail.com
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Cited By...

Disputes & Debates: Rapid online correspondence

  • Author Response to Dr. Sethi
    • Helene E.K. Sundelin, Department of Pediatrics, University Hospital, Linkoping, Sweden
    • Jonas F. Ludvigsson, Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; and Department of Pediatrics, Orebro University Hospital, Orebro University, Orebro, Sweden
    Submitted August 16, 2016
  • Austism and epilepsy: A "chicken or egg" situation
    • Nitin K. Sethi, Assistant Professor of Neurology, New York-Presbyterian Hospital, Weill Cornell Medical Center 525 East 68th Street, New York, NY 1006
    Submitted July 25, 2016
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