Abstract
In light of the published 2012 International Pediatric Multiple Sclerosis Group definitions for pediatric multiple sclerosis (MS) and related disorders and given that pediatric-onset MS is now formally included in the 2010 McDonald criteria for MS, we sought to review these criteria and summarize their application in children with acquired CNS demyelination. In addition, proposals are made for definitions of no evidence of disease activity and inadequate treatment response that are important because of new therapeutic options and trials.
GLOSSARY
- ADEM=
- acute disseminated encephalomyelitis;
- ARR=
- annualized relapse rate;
- CIS=
- clinically isolated syndrome;
- DIS=
- dissemination of inflammatory lesions in space;
- DIT=
- dissemination of inflammatory lesions in time;
- EDSS=
- Expanded Disability Status Scale;
- IPMSSG=
- International Pediatric Multiple Sclerosis Study Group;
- MOG=
- myelin oligodendroglial glycoprotein;
- MS=
- multiple sclerosis;
- NEDA=
- no evidence of disease activity;
- NMO=
- neuromyelitis optica;
- RIS=
- radiologically isolated syndrome
Footnotes
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
- Received August 19, 2015.
- Accepted in final form March 1, 2016.
- © 2016 American Academy of Neurology
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