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August 30, 2016; 87 (9 Supplement 2) Article

Pediatric multiple sclerosis

Conventional first-line treatment and general management

Angelo Ghezzi, Maria Pia Amato, Naila Makhani, Teri Shreiner, Jutta Gärtner, Silvia Tenembaum
First published August 29, 2016, DOI: https://doi.org/10.1212/WNL.0000000000002823
Angelo Ghezzi
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Maria Pia Amato
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Naila Makhani
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Teri Shreiner
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Jutta Gärtner
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Silvia Tenembaum
From the Divisione di Neurologia 2–Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate; Department NEUROFARBA (M.P.A.), Section of Neurosciences, University of Florence, Italy; Division of Neurology (N.M.), Department of Pediatrics and Neurology, Yale School of Medicine, New Haven, CT; Department of Neurology (T.S.), University of Colorado Denver Anschutz Medical Campus, Aurora; Department of Pediatrics and Pediatric Neurology and German Center for Multiple Sclerosis in Childhood and Adolescence (J.G.), University Medicine Göttingen, Germany; and Department of Neurology (S.T.), National Pediatric Hospital Dr. Juan P. Garrahan, Buenos Aires, Argentina.
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Citation
Pediatric multiple sclerosis
Conventional first-line treatment and general management
Angelo Ghezzi, Maria Pia Amato, Naila Makhani, Teri Shreiner, Jutta Gärtner, Silvia Tenembaum
Neurology Aug 2016, 87 (9 Supplement 2) S97-S102; DOI: 10.1212/WNL.0000000000002823

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This article has a correction. Please see:

  • Pediatric multiple sclerosis: Conventional first-line treatment and general management - November 08, 2016
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Abstract

Many disease-modifying therapies are currently available for adults with relapsing-remitting multiple sclerosis (MS) but none of them has been tested in pediatric MS in randomized placebo-controlled trials. At present, as suggested by observational studies and experts' guidelines, interferon-β and glatiramer acetate continue to be the standard first-line treatments for pediatric MS. Observational studies and some controlled unblinded trials have shown a positive effect of these meditations in reducing relapse rate and delaying disease progression, with an acceptable safety profile. The goal of this article is to provide an overview of current knowledge with regard to safety, tolerability, and efficacy of first-line treatment options for MS in the pediatric age group, with the aim of providing guidance for planning first-line treatment of MS in children and adolescents.

GLOSSARY

DMT=
disease-modifying therapies;
GA=
glatiramer acetate;
IFN-β=
interferon-β;
MS=
multiple sclerosis;
NAb=
neutralizing antibodies;
RRMS=
relapsing-remitting multiple sclerosis

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received August 19, 2015.
  • Accepted in final form January 19, 2016.
  • © 2016 American Academy of Neurology
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  • Article
    • Abstract
    • GLOSSARY
    • CURRENT VIEWS OF FIRST-LINE TREATMENT IN PEDIATRIC MS
    • RESULTS IN YOUNG CHILDREN VS ADOLESCENTS
    • DMT IN CLINICAL PRACTICE
    • DISCUSSION
    • AUTHOR CONTRIBUTIONS
    • STUDY FUNDING
    • DISCLOSURE
    • Footnotes
    • REFERENCES
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