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January 03, 2017; 88 (1) Editorial

Orthostatic hypotension, cognition, and Parkinson disease

Dumbing down by standing up

Laura S. Boylan, Lambros Messinis
First published November 30, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003468
Laura S. Boylan
From the Department of Neurology (L.S.B.), New York University School of Medicine, New York; Department of Neurology (L.S.B.), Essentia Health, Duluth, MN; Department of Neurology (L.S.B.), Bellevue Hospital, New York, NY; and Neuropsychology Section, Department of Neurology (L.M.), University of Patras Medical School, Greece.
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Lambros Messinis
From the Department of Neurology (L.S.B.), New York University School of Medicine, New York; Department of Neurology (L.S.B.), Essentia Health, Duluth, MN; Department of Neurology (L.S.B.), Bellevue Hospital, New York, NY; and Neuropsychology Section, Department of Neurology (L.M.), University of Patras Medical School, Greece.
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Orthostatic hypotension, cognition, and Parkinson disease
Dumbing down by standing up
Laura S. Boylan, Lambros Messinis
Neurology Jan 2017, 88 (1) 11-12; DOI: 10.1212/WNL.0000000000003468

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Orthostatic hypotension (OH) is associated with cognitive impairment in otherwise healthy individuals as well as among those with neurodegenerative diseases. There is much current interest in the OH–cognitive impairment connection.1–4 OH and cognitive impairment are both common in Parkinson disease and can lower quality of life. Nonpharmacologic and pharmacologic treatments for OH are readily available, while treatments to modify the course of neurodegenerative cognitive impairment are nil. If the association between OH and cognitive impairment is causal and OH damages the brain, a promising window of therapeutic opportunity suggests itself. Alternately, OH and cognitive impairment are simply markers of a shared pathologic substrate.

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  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

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  • © 2016 American Academy of Neurology
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