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Orthostatic hypotension (OH) is associated with cognitive impairment in otherwise healthy individuals as well as among those with neurodegenerative diseases. There is much current interest in the OH–cognitive impairment connection.1–4 OH and cognitive impairment are both common in Parkinson disease and can lower quality of life. Nonpharmacologic and pharmacologic treatments for OH are readily available, while treatments to modify the course of neurodegenerative cognitive impairment are nil. If the association between OH and cognitive impairment is causal and OH damages the brain, a promising window of therapeutic opportunity suggests itself. Alternately, OH and cognitive impairment are simply markers of a shared pathologic substrate.
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- © 2016 American Academy of Neurology
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