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January 03, 2017; 88 (1) Editorial

A gestational dose of vitamin D per day keeps the MS doctor away

Ruth Ann Marrie, Martin Daumer
First published November 30, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003469
Ruth Ann Marrie
From the Departments of Internal Medicine and Community Health Sciences (R.A.M.), University of Manitoba, Winnipeg, Canada; and Sylvia Lawry Centre for Multiple Sclerosis Research eV–The Human Motion Institute (M.D.), Munich, Germany.
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Martin Daumer
From the Departments of Internal Medicine and Community Health Sciences (R.A.M.), University of Manitoba, Winnipeg, Canada; and Sylvia Lawry Centre for Multiple Sclerosis Research eV–The Human Motion Institute (M.D.), Munich, Germany.
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A gestational dose of vitamin D per day keeps the MS doctor away
Ruth Ann Marrie, Martin Daumer
Neurology Jan 2017, 88 (1) 13-14; DOI: 10.1212/WNL.0000000000003469

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Interest in identifying the cause of multiple sclerosis (MS) remains intense. Two nested case-control studies showed that in young, predominantly white adults in whom samples were collected before clinical disease onset, higher serum levels of 25(OH)D were associated with a reduced risk of developing MS.1,2 In the Nurses' Health Study cohorts, higher dietary intake of vitamin D was associated with a lower risk of developing MS among American nurses; supplemental intake of more than 400 IU daily was associated with a 40% reduced risk. A more recent mendelian randomization study, which included 14,498 MS cases and 24,091 healthy controls with European ancestry, showed that alleles related to lower vitamin D levels were associated with increased MS risk.2,3 This study design increases the confidence that the preceding observations reflect a causal association rather than confounding. However, the time period when vitamin D exposure is relevant to reducing MS risk remains uncertain, including whether early-life exposure to vitamin D influences MS risk.2,4

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  • © 2016 American Academy of Neurology
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