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January 03, 2017; 88 (1) Article

Effects of orthostatic hypotension on cognition in Parkinson disease

Justin Centi, Roy Freeman, Christopher H. Gibbons, Sandy Neargarder, Alexander O. Canova, Alice Cronin-Golomb
First published November 30, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003452
Justin Centi
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Roy Freeman
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Christopher H. Gibbons
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Sandy Neargarder
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Alexander O. Canova
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Alice Cronin-Golomb
From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
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Full PDF
Citation
Effects of orthostatic hypotension on cognition in Parkinson disease
Justin Centi, Roy Freeman, Christopher H. Gibbons, Sandy Neargarder, Alexander O. Canova, Alice Cronin-Golomb
Neurology Jan 2017, 88 (1) 17-24; DOI: 10.1212/WNL.0000000000003452

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Article Information

vol. 88 no. 1 17-24
DOI: 
https://doi.org/10.1212/WNL.0000000000003452
PubMed: 
27903817

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 7, 2016
  • Accepted in final form August 24, 2016
  • First Published November 30, 2016.

Article Versions

  • Previous version (November 30, 2016 - 13:00).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2016 American Academy of Neurology

Author Disclosures

    1. Justin Centi, PhD,
    2. Roy Freeman, MD*,
    3. Christopher H. Gibbons, MD,
    4. Sandy Neargarder, PhD,
    5. Alexander O. Canova, BA and
    6. Alice Cronin-Golomb, PhD*
  1. Justin Centi, PhD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. 1) Commonwealth Psychology Associates LLC; Clinical Neuropsychologist, 9/2015- 2) Harvard Medical School/Partners Consortium in Neuropsychology; Postdoctoral Fellow, 9/2013-9-2015

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NIH-NINDS Ruth L. Kirschstein National Research Service Award 1F31NS074801-01, 2010-2013

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Roy Freeman, MD*,
  4. Scientific Advisory Boards:
    1. (1) Astellas (2) Abide (3) Biogen (4) Dong A (5) Glenmark (6) Insys (7) Daiishi-Sankyo (8) Lundbeck (9) Pfizer (10) Shire (11) Spinifex (12) Nestle

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Autonomic Neuroscience - Basic and Clinical, Editor (2007-present) Clinical Autonomic Research, Editorial Board (1999-present) Clinical Journal of Pain, Assoc. Editor, 2009-2012 Clinical Journal of Pain, Editorial Board (2009-present)

    Patents:
    1. NONE

    Publishing Royalties:
    1. Royalties from UptoDate

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1.) Impeto (2) Nestle (3) Pfizer

    Research Support, Government Entities:
    1. (1) NIH (NHBLI), R01HL111465-01A1, PI 08/27/13-06/30/17 (2) NIH (NINDS), U54 NS 065736, Co-PI, 09/30/15-06/30/2020

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Multiple system atrophy consortium

    Stock/Stock Options/Board of Directors Compensation:
    1. (1) Spinifex

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Christopher H. Gibbons, MD,
  6. Scientific Advisory Boards:
    1. Served on a Scientific Advisory Board for Lundbeck. Served on a Data Safety Monitoring Board for Astellas and Janssen.

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. RJG Foundation

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Sandy Neargarder, PhD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Alexander O. Canova, BA and
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Alice Cronin-Golomb, PhD*
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. 1) Consulting editor, Behavioral Neuroscience. Served as Guest Associate Editor for a special issue of this journal in 2016.

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. 1) Professor of Psychological and Brain Sciences, Boston University, Boston MA

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. 1) Veterans Administration 1I01RX001696, Investigator 2) (NIH) R01 AG050595, Investigator 3)(NIH) R01NS067128, Principal Investigator 4)(NIH)R01 EY022229, Investigator

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. 1) American Parkinson Disease Foundation

    Stock/Stock Options/Board of Directors Compensation:
    1. Posit Science; on Scientific Advisory Board in the past (not Board of Directors)

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Psychological and Brain Sciences (J.C., S.N., A.O.C., A.C.-G.), Boston University, Boston; Department of Neurology (J.C., R.F., C.H.G.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; and Department of Psychology (S.N.), Bridgewater State University, Bridgewater, MA.
  1. Correspondence to Dr. Cronin-Golomb: alicecg{at}bu.edu
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Cited By...

  • 63 Citations
  • Google Scholar

Letters: Rapid online correspondence

  • Author response: Orthostatic hypotension, per se, can cause transient worsening of cognition
    • Justin Centi, Clinical Neuropsychologist, Boston Universitycenti@commpsych.com
    • Roy Freeman, Christopher H. Gibbons, Sandy Neargarder, Alexander O. Canova, Alice Cronin-Golomb
    Submitted August 10, 2017
  • Orthostatic hypotension, per se, can cause transient worsening of cognition
    • Pietro Guaraldi, MD, Neurology Otpatient Clinic, Department of Primary Care, Local Health Authority of Modenap.guaraldi@ausl.mo.it
    • Roberto Poda, Giovanna Calandra-Buonaura, Bologna, Italy; L Solieri; L Sambati; Roberto Gallassi, Pietro Cortelli, Bologna, Italy
    Submitted May 12, 2017
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