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March 07, 2017; 88 (10) Editorial

Neurofilament light

A heavyweight diagnostic biomarker in neurodegenerative parkinsonism?

Guido Alves, Laura Bonanni
First published February 8, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003699
Guido Alves
From The Norwegian Centre for Movement Disorders (G.A.) and Department of Neurology (G.A.), Stavanger University Hospital, Norway; and the Department of Neuroscience Imaging and Clinical Sciences (L.B.), University G. d'Annunzio of Chieti-Pescara, Italy.
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Laura Bonanni
From The Norwegian Centre for Movement Disorders (G.A.) and Department of Neurology (G.A.), Stavanger University Hospital, Norway; and the Department of Neuroscience Imaging and Clinical Sciences (L.B.), University G. d'Annunzio of Chieti-Pescara, Italy.
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Neurofilament light
A heavyweight diagnostic biomarker in neurodegenerative parkinsonism?
Guido Alves, Laura Bonanni
Neurology Mar 2017, 88 (10) 922-923; DOI: 10.1212/WNL.0000000000003699

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Neurodegenerative parkinsonian disorders were historically divided into 2 major groups based on their clinical picture, treatment response, and prognosis. One group encompassed Parkinson disease (PD), characterized at onset by usually asymmetrical extrapyramidal motor symptoms showing a marked and sustained response to levodopa, and subsequent slow motor decline over time. The other group included the much rarer atypical parkinsonian disorders (APDs), including multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), with features signaling early autonomous, pyramidal, or cortical involvement, poor motor response to levodopa, and a much more rapid functional decline and higher mortality than usually seen in PD.1

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  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the author, if any, are provided at the end of the editorial.

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  • © 2017 American Academy of Neurology
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