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March 28, 2017; 88 (13) Article

Nonpainful remote electrical stimulation alleviates episodic migraine pain

David Yarnitsky, Lana Volokh, Alon Ironi, Boaz Weller, Merav Shor, Alla Shifrin, Yelena Granovsky
First published March 1, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003760
David Yarnitsky
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Lana Volokh
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Alon Ironi
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Boaz Weller
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Merav Shor
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Alla Shifrin
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Yelena Granovsky
From Rambam Healthcare Campus and Technion Faculty of Medicine (D.Y., M.S., A.S., Y.G.), Haifa; Theranica Ltd. (L.V., A.I.), Netanya; and Bnei Zion Medical Center (B.W.), Haifa, Israel.
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Citation
Nonpainful remote electrical stimulation alleviates episodic migraine pain
David Yarnitsky, Lana Volokh, Alon Ironi, Boaz Weller, Merav Shor, Alla Shifrin, Yelena Granovsky
Neurology Mar 2017, 88 (13) 1250-1255; DOI: 10.1212/WNL.0000000000003760

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Abstract

Objective: To evaluate the efficacy of remote nonpainful electrical upper arm skin stimulation in reducing migraine attack pain.

Methods: This is a prospective, double-blinded, randomized, crossover, sham-controlled trial. Migraineurs applied skin electrodes to the upper arm soon after attack onset for 20 minutes, at various pulse widths, and refrained from medications for 2 hours. Patients were asked to use the device for up to 20 attacks.

Results: In 71 patients (299 treatments) with evaluable data, 50% pain reduction was obtained for 64% of participants based on best of 200-μs, 150-μs, and 100-μs pulse width stimuli per individual vs 26% for sham stimuli. Greater pain reduction was found for active stimulation vs placebo; for those starting at severe or moderate pain, reduction (1) to mild or no pain occurred in 58% (25/43) of participants (66/134 treatments) for the 200-μs stimulation protocol and 24% (4/17; 8/29 treatments) for placebo (p = 0.02), and (2) to no pain occurred in 30% (13/43) of participants (37/134 treatments) and 6% (1/17; 5/29 treatments), respectively (p = 0.004). Earlier application of the treatment, within 20 minutes of attack onset, yielded better results: 46.7% pain reduction as opposed to 24.9% reduction when started later (p = 0.02).

Conclusion: Nonpainful remote skin stimulation can significantly reduce migraine pain, especially when applied early in an attack. This is presumably by activating descending inhibition pathways via the conditioned pain modulation effect. This treatment may be proposed as an attractive nonpharmacologic, easy to use, adverse event free, and inexpensive tool to reduce migraine pain.

ClinicalTrials.gov identifier: NCT02453399.

Classification of evidence: This study provides Class III evidence that for patients with an acute migraine headache, remote nonpainful electrical stimulation on the upper arm skin reduces migraine pain.

GLOSSARY

ANOVA=
analysis of variance;
CPM=
conditioned pain modulation;
ITT=
intention-to-treat;
NNT=
number needed to treat;
NPS=
Numeric Pain Scale;
ONS=
occipital nerve stimulation

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received June 23, 2016.
  • Accepted in final form December 27, 2016.
  • © 2017 American Academy of Neurology
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