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March 28, 2017; 88 (13) Article

Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease

Gregory S. Day, Tae Sung Lim, Jason Hassenstab, Alison M. Goate, Elizabeth A. Grant, Catherine M. Roe, Nigel J. Cairns, John C. Morris
First published February 24, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003770
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Article Information

vol. 88 no. 13 1273-1281
DOI: 
https://doi.org/10.1212/WNL.0000000000003770
PubMed: 
28235814
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 29, 2016
  • Accepted in final form January 3, 2017
  • First Published February 24, 2017.

Article Versions

Copyright & Usage: 
© 2017 American Academy of Neurology

Author Disclosures

    1. Gregory S. Day, MD, MSc*,
    2. Tae Sung Lim, MD, PhD*,
    3. Jason Hassenstab, PhD,
    4. Alison M. Goate, PhD,
    5. Elizabeth A. Grant, PhD,
    6. Catherine M. Roe, PhD,
    7. Nigel J. Cairns, PhD, FRCPath‡ and
    8. John C. Morris, MD‡
  1. Gregory S. Day, MD, MSc*,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Avid Pharmaceuticals (provision of radiotracer for ongoing research study).

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. American Brain Foundation, Clinical Research Training Fellowship (2016-17) 2. Eugene M Johnson Jr, Weston Brain Institute Postdoctoral Fellowship (2015 Recipient)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. 1) Hold stocks (>$10,000) in ANI Pharmaceuticals (a generic pharmaceutical company; 2015 onward).

    Legal Proceedings:

    1. NONE

  2. Tae Sung Lim, MD, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Jason Hassenstab, PhD,
    4. Scientific Advisory Boards:

    1. Scientific advisory board: Biogen

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Clinical and Experimental Neuropsychology, Associate Editor, 2014-present Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Associate Editor, 2015-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant for Biogen

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH, K23DK094982, PI, 2012-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Alison M. Goate, PhD,
    5. Scientific Advisory Boards:

    1. (1) Denali Therapeutics

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Rainwater Foundation 2014-2016 travel to attend meeting Indiana University 2015, 2016

    Editorial Boards:

    1. eLife

    Patents:

    1. PSEN mutations in AD Tau mutations in FTD TDP43 mutations in ALS\FTD

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Cognition Therapeutics 2015 AbbVie 2016

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. F Prime

    Research Support, Government Entities:

    1. 1. NIA 1R01AG035083- (Goate) PI 9/1/10-8/31/15 2. NIA 1U01AG032984-01 (Schellenberg\Goate) Co- Investigator/Core Director 4/1/09-3/31/14 3. NIA U01 AG049508-01 Goate (PI) 6/11/14-5/31/18 4. NIA R01 AGO41797-03 Goate Site PI 4/1/12-3/13/17 5. NIA U01 AG052411 Goate (PI) 8/1/2016-7/31/2020 6. NIA RF1AG05401 Goate (PI) 08/01/16-06/30/21 7. NIA 5U01AG032438-07 (Morris) Co-Investigator/Core Director 9/15/08-6/30/19 8. NIAAA 5U10AA08401-25 (Goate/ site PI) Co-Investigator 9/29/89-8/31/19

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. Rainwater Charitable Foundation 2. JPB Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Taconic Industries for tau mutation patent

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Elizabeth A. Grant, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIA, P01AG003991, salary/research support 2) NIA, P50AG005681, salary/research support 3) NIA, P01AG026276, salary/research support 4) NIA, U01AG016976, salary support 5) NIA, U24AG026395, salary support

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Catherine M. Roe, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) BMC Neurology, Associate Editor (2) Journal of Alzheimer's Disease

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Salary support from NIH/NIA (R01 AG04343401, R01 AG15928- 02, P50-AG05681, P50-AG0568129 and P01- AG03991), the Washington University Strategic Research Alliance, from the Charles and Joanne Knight Alzheimer Research Initiative of the Knight Alzheimer?s Disease Research Center, The Farrell Family Research Fund, and The generous support of F Simmons and O Mohan.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Salary support from NIH/NIA (R01 AG04343401, R01 AG15928- 02, P50-AG05681, P50-AG0568129 and P01- AG03991),

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Charles and Joanne Knight Alzheimer Research Initiative of the Knight Alzheimer?s Disease Research Center, the Washington University Strategic Research Alliance, The Farrell Family Research Fund, and The generous support of F Simmons and O Mohan

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Nigel J. Cairns, PhD, FRCPath‡ and
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. I am on the editorial board of Brain Pathology.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. Support for this work was provided by grants from the NIH (National Institute on Aging, P50-AG05681 and P01- AG03991), and the Charles Knight Fund.

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. John C. Morris, MD‡
    9. Scientific Advisory Boards:

    1. Lilly USA; Takeda Pharmaceuticals

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Serves on the editorial advisory board of JAMA Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. 1. Blackwell Publishing, 2009, for Burns J and Morris JC, “Mild Cognitive Impairment and Early Alzheimer's Disease”, copyright 2008 by John Wiley and Sons, Ltd 2. Taylor & Francis 2008; “Handbook of Dementing Illnesses, 2 Ed”, Morris JC, Galvin JE, Holtzman DM, Eds, copyright 2006

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Receives research support from Eli Lilly/Avid Radiopharmaceuticals

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Charles F. and Joanne Knight Alzheimer Disease Research Center (G.S.D., T.S.L., J.H., A.M.G., E.A.G., C.M.R., N.J.C., J.C.M.), Department of Neurology (G.S.D., T.S.L., J.H., C.M.R., N.J.C., J.C.C.), Division of Biostatistics (E.A.G.), and Department of Pathology and Immunology (N.J.C.), Washington University School of Medicine (G.S.D., T.S.L., J.H., A.M.G., E.A.G., C.M.R., N.J.C., J.C.M.), St. Louis, MO; Ajou University School of Medicine (T.S.L.), Suwon, Republic of Korea; and Icahn School of Medicine at Mount Sinai (A.M.G.), New York, NY.
  1. Correspondence to Dr. Morris: jcmorris{at}wustl.edu
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