Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

April 18, 2017; 88 (16 Supplement) April 23, 2017

Increased Cysteinylated Albumin is Associated with More Favorable Outcomes in Ischemic Stroke Patients, A Reflection of Collateral Circulation? (P1.261)

Russell Bartt, Jan Leonard, Raphael Bar-Or, Leonard Rael, David Bar-Or
First published April 17, 2017,
Russell Bartt
1Blue Sky Neurosciences, LLP Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Leonard
2Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raphael Bar-Or
2Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonard Rael
2Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Bar-Or
2Swedish Medical Center Englewood CO United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Increased Cysteinylated Albumin is Associated with More Favorable Outcomes in Ischemic Stroke Patients, A Reflection of Collateral Circulation? (P1.261)
Russell Bartt, Jan Leonard, Raphael Bar-Or, Leonard Rael, David Bar-Or
Neurology Apr 2017, 88 (16 Supplement) P1.261;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: To determine whether admission albumin levels and the cysteinylation of albumin in acute ischemic stroke (AIS) patients were associated with stroke severity and outcomes.

Background: Studies have shown an association between low serum albumin and poor outcomes in AIS patients. Cysteinylation of albumin is the result of oxidation of its only free cysteine (cys34) which accounts for the majority of reductant capacity in plasma.

Design/Methods: At a Comprehensive Stroke Center, plasma samples were prospectively collected (2010–2011), and clinical data were abstracted for AIS patients (n=107). Cysteinylation of serum albumin (% of total albumin) was measured in AIS patients and healthy controls (n=12) using HPLC coupled to mass spectrometry; this was used to calculate the actual level of cysteinylated albumin (admission albumin × % cysteinylated). ANOVA or Chi-square trend tests were used to examine the association between stroke severity, outcomes (length of stay [LOS], discharge mRS≤2, in-hospital mortality) and quartile of albumin and cysteinylated albumin.

Results: Elevated levels of cysteinylated albumin were detected in AIS patients (40.7±7.8%) compared to the controls (32.3±3.5%), p<0.001. No association was found between stroke severity or LOS and albumin or cysteinylated albumin. Increasing albumin (≤3.10 mg/ml, >3.10–3.45 mg/ml, >3.45–3.85 mg/ml, >3.85 mg/ml) at admission was associated with decreasing mortality (15.6%, 12.5%, 8.3%, 0%, p = 0.047). Cysteinylated albumin was associated with discharge mRS and mortality. As the cysteinylated albumin increased (≤1.17 mg/ml, >1.17–1.37 mg/ml, >1.37–1.63 mg/ml, >1.63 mg/ml), the percent of patients with a discharge mRS≤2 increased (24.0%, 30.4%, 41.7%, 58.3%, p=0.01), while in-hospital mortality decreased (16.0%, 17.4%, 4.2%, 0%, p=0.02).

Conclusions: Increasing levels of cysteinylated albumin were associated with more favorable discharge mRS and less mortality. Cysteinylated (oxidized) albumin may reflect the presence of collateral circulation in equilibrium with the peripheral circulation from where venous blood samples were obtained for this study.

Disclosure: Dr. Bartt has nothing to disclose. Dr. Leonard has nothing to disclose. Dr. Bar-Or has nothing to disclose. Dr. Rael has nothing to disclose. Dr. Bar-Or has nothing to disclose.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Dr. Sevil Yaşar and Dr. Behnam Sabayan

► Watch

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 101 (13)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise