Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

April 18, 2017; 88 (16 Supplement) April 23, 2017

Apixaban for the treatment of Cerebral Venous Thrombosis: A Report of Two Cases (P1.281)

Shishir Rao, Kushak Suchdev, Claudia Hanni, Mohammad Ibrahim, Dennis Parker, Kumar Rajamani, Wazim Mohamed
First published April 17, 2017,
Shishir Rao
1Department of Neurology, Detroit Medical Center/Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kushak Suchdev
1Department of Neurology, Detroit Medical Center/Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claudia Hanni
2Department of Pharmacology, Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mohammad Ibrahim
1Department of Neurology, Detroit Medical Center/Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dennis Parker Jr.
2Department of Pharmacology, Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kumar Rajamani
1Department of Neurology, Detroit Medical Center/Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wazim Mohamed
1Department of Neurology, Detroit Medical Center/Wayne State University Detroit MI United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Apixaban for the treatment of Cerebral Venous Thrombosis: A Report of Two Cases (P1.281)
Shishir Rao, Kushak Suchdev, Claudia Hanni, Mohammad Ibrahim, Dennis Parker, Kumar Rajamani, Wazim Mohamed
Neurology Apr 2017, 88 (16 Supplement) P1.281;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: Cerebral venous sinus thrombosis (CVT) is usually treated with heparin and warfarin. Newer anticoagulants are now available but the safety and efficacy of newer drugs is not established.

Background: CVT is an uncommon, often under diagnosed and under treated neurological condition. Traditionally patients are treated with intravenous heparin followed by an oral vitamin K antagonist like warfarin. Direct oral anticoagulants (DOACs) are currently available and may offer advantages over warfarin. There is some evidence to demonstrate the effectiveness of both dabigatran and rivaroxaban. No studies have previously described the use of apixaban in CVT.

Design/Methods: Report two cases of CVT treated with apixaban, review of literature on available treatment options; efficacy and safety of novel oral anticoagulants in patients with systemic thrombosis.

Results: Two patients, a 21 year old woman and a 37 year old African American man, presented with features of cerebral venous sinus thrombosis. While the first patient presented with severe unremitting headache with papilledema due to raised intracranial pressure, the second patient presented with seizures and focal weakness due to parenchymal hemorrhage. After confirming the diagnosis of cerebral venous thrombosis, they were acutely treated with heparin, and subsequently discharged on apixaban. During follow up visits, both patients tolerated apixaban well and did not have any bleeding complications. Follow up scans at 6 weeks for both patients showed resolution of thrombosis and complete recanalization.

Conclusions: CVT is a neurological emergency and is often complicated by associated intraparenchymal hemorrhage which increases the risk of anticoagulation. When compared to both older agents like warfarin and newer oral anticoagulants, including dabigatran and rivaroxaban, apixaban has a lower risk of major bleeding and complications. Therefore, apixaban may be a safe and effective option for the treatment of CVT.

Disclosure: Dr. Rao has nothing to disclose. Dr. Suchdev has nothing to disclose. Dr. Hanni has nothing to disclose. Dr. Ibrahim has nothing to disclose. Dr. Parker Jr. has nothing to disclose. Dr. Rajamani has nothing to disclose. Dr. Mohamed has nothing to disclose.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 96 (8)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise