Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • COVID-19
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • Topics A-Z
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

April 18, 2017; 88 (16 Supplement) April 27, 2017

Castleman disease with follicular dendritic cell sarcoma presenting with pseudotumor cerebri and myasthenia gravis (P5.189)

Alexander Fein, Humberto Trejo Bittar, Manisha Shende, Ernest Scalzetti, Melissa Ko
First published April 17, 2017,
Alexander Fein
1SUNY Upstate Medical University Syracuse NY United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Humberto Trejo Bittar
4Pathology Pittsburgh PA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manisha Shende
5Cardiothoracic Surgery, University of Pittsburgh Medical Center Pittsburgh PA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ernest Scalzetti
2Radiology Syracuse NY United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melissa Ko
3Neurology and Ophthalmology, SUNY Upstate Medical University Syracuse NY United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Castleman disease with follicular dendritic cell sarcoma presenting with pseudotumor cerebri and myasthenia gravis (P5.189)
Alexander Fein, Humberto Trejo Bittar, Manisha Shende, Ernest Scalzetti, Melissa Ko
Neurology Apr 2017, 88 (16 Supplement) P5.189;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: This case highlights a rare combination of pseudotumor cerebri (PTC), myasthenia gravis (MG), and Castleman disease (CD).

Background: Castleman disease is a lymphoproliferative disorder that has previously been associated with PTC or MG. This is a rare case of CD with follicular dendritic cell sarcoma (FDCS) presenting with PTC and subsequently MG.

Design/Methods: Case study report.

Results: A 21-year-old woman presented with headache, blurred vision and pulsatile tinnitus in the setting of recent weight gain. On exam, she demonstrated VA: 20/20-1 OU, bilateral optic disc elevation, and noted blind spot enlargement OD. MRI brain was within normal limits. Lumbar puncture showed an elevated opening pressure of 38 cm of water with normal CSF composition and a diagnosis of pseudotumor cerebri was made. Acetazolamide was initiated along with a weight loss regimen. On follow-up, she had lost 18 lbs with resolved symptoms and papilledema. However, she reported new symptoms including facial asymmetry and fatigue with extended speech and reading. Due to worsening dysphagia and facial weakness, acetylcholine receptor antibodies were obtained and noted to be elevated. A diagnosis of myasthenia gravis was made, and pyridostigmine was initiated. A CT thorax with contrast was obtained revealing a posterior mediastinal mass. Upon resection, histology of the mass showed follicular dendritic cell sarcoma in the setting of hyaline vascular Castleman disease. The patient has been asymptomatic following treatment with IVIG, pyridostigmine and acetazolamide.

Conclusions: To our knowledge, this is the first reported case of unicentric CD with FDCS presenting with PTC and MG. A potential unifying pathophysiology could involve the elevation of interleukin-6, which has been previously described to contribute to lymphoproliferation associated with cases of CD and CD with MG. Elevated IL-6 levels in serum and CSF have been noted in PTC, which may be a linking factor to CD or an epiphenomenon.

Disclosure: Dr. Fein has nothing to disclose. Dr. Trejo Bittar has nothing to disclose. Dr. Shende has nothing to disclose. Dr. Scalzetti has nothing to disclose. Dr. Ko has nothing to disclose.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise