April 25, 2017; 88 (17) Article
Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD
Stephanie A. Schultz, Elizabeth A. Boots, Burcu F. Darst, Henrik Zetterberg, Kaj Blennow, Dorothy F. Edwards, Rebecca L. Koscik, Cynthia M. Carlsson, Catherine L. Gallagher, Barbara B. Bendlin, Sanjay Asthana, Mark A. Sager, Kirk J. Hogan, Bruce P. Hermann, Dane B. Cook, Sterling C. Johnson, Corinne D. Engelman, Ozioma C. Okonkwo
First published March 24, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003862
Stephanie A. Schultz
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Elizabeth A. Boots
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Burcu F. Darst
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Henrik Zetterberg
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Kaj Blennow
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Dorothy F. Edwards
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Rebecca L. Koscik
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Cynthia M. Carlsson
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Catherine L. Gallagher
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Barbara B. Bendlin
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Sanjay Asthana
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Mark A. Sager
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Kirk J. Hogan
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Bruce P. Hermann
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Dane B. Cook
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Sterling C. Johnson
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Corinne D. Engelman
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Ozioma C. Okonkwo
From the Geriatric Research Education and Clinical Center (S.A.S., E.A.B., C.M.C., C.L.G., B.B.B., S.A., S.C.J., O.C.O.) and Research Service (D.B.C.), William S. Middleton Memorial VA Hospital, Madison, WI; Wisconsin Alzheimer's Disease Research Center (S.A.S., E.A.B., D.F.E., R.L.K., C.M.C., B.B.B., S.A., M.A.S., B.P.H., S.C.J., C.D.E., O.C.O.), Madison; Departments of Population Health Sciences (B.F.D., C.D.E.), Kinesiology (D.F.E., D.B.C.), Neurology (C.L.G.), and Anesthesiology (K.J.H.), University of Wisconsin School of Medicine and Public Health, Madison; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Wisconsin Alzheimer's Institute (D.F.E., C.M.C., C.L.G., B.B.B., S.A., M.A.S., K.J.H., B.P.H., S.C.J., C.D.E., O.C.O.), Madison.
Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD
Stephanie A. Schultz, Elizabeth A. Boots, Burcu F. Darst, Henrik Zetterberg, Kaj Blennow, Dorothy F. Edwards, Rebecca L. Koscik, Cynthia M. Carlsson, Catherine L. Gallagher, Barbara B. Bendlin, Sanjay Asthana, Mark A. Sager, Kirk J. Hogan, Bruce P. Hermann, Dane B. Cook, Sterling C. Johnson, Corinne D. Engelman, Ozioma C. Okonkwo
Neurology Apr 2017, 88 (17) 1650-1658; DOI: 10.1212/WNL.0000000000003862
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