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May 23, 2017; 88 (21) Article

Alcohol use and risk of intracerebral hemorrhage

Ching-Jen Chen, W. Mark Brown, Charles J. Moomaw, Carl D. Langefeld, Jennifer Osborne, Bradford B. Worrall, Daniel Woo, Sebastian Koch, For the ERICH Investigators
First published April 26, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003952
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Article Information

vol. 88 no. 21 2043-2051
DOI: 
https://doi.org/10.1212/WNL.0000000000003952
PubMed: 
28446657
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 1, 2016
  • Accepted in final form March 1, 2017
  • First Published April 26, 2017.

Article Versions

Copyright & Usage: 
© 2017 American Academy of Neurology

Author Disclosures

    1. Ching-Jen Chen, MD,
    2. W. Mark Brown, MA,
    3. Charles J. Moomaw, PhD,
    4. Carl D. Langefeld, PhD,
    5. Jennifer Osborne, RN, BSN,
    6. Bradford B. Worrall, MD, MSc,
    7. Daniel Woo, MD, MS,
    8. Sebastian Koch, MD;
    9. For the ERICH Investigators
  1. Ching-Jen Chen, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. W. Mark Brown, MA,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Charles J. Moomaw, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NINDS, R01NS030678, data manager, 2004-2017, (2) NINDS, R01NS036695, data manager, 2008-2013,2016-2017, (3) NINDS, R01NS039512, data manager, 2002-2012, (4) NINDS, K23NS049463, data manager, 2006-2011, (5) NINDS, U01NS069208, data manager, 2010?2014, (6) NINDS, U01NS069763, data manager, 2010-2016, (7) NINDS, U01NS086872, data analyst, 2014?2017, (8) NINDS, R01NS093878, data manager, 2016-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Carl D. Langefeld, PhD,
    5. Scientific Advisory Boards:

    1. (2) Oklahoma Medical Research Foundation, Wake Forest Nonhuman Primate Center

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. (2) NIH;

    Editorial Boards:

    1. Rheumatic Disease Clinics

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. U01 NS069763-01 08/01/2010 - 07/31/2016 NINDS Minorities with Ischemic Stroke Study (ERICH) PI of Biostatistics and Bioinformatics Center P01 AR048929 09/01/2011 ? 08/30/2016 NIH Gene Expression in Pediatric Arthritis PI of Analysis Center Subcontract P30 CA12197 02/01/2012 ? 01/31/2017 NCI Comprehensive Cancer Center of Wake Forest University- Cancer Center Support Grant Co-Investigator HG007112 -01 05/01/2012 ? 03/31/2017 NIH Exome Sequencing to Identify CVD Risk Variants in Hispanic and African Americans Co-PI R01 DK090111-01 04/01/2011 - 03/31/2017 NIDDK Mapping Diabetes Susceptibility by expression traits in African Americans Co-Investigator R01 DK071891 07/01/2005 ? 06/30/2017 NIDDK Subclinical DVD in African American Type 2 Diabetes Co-Investigator R21 DK106554 08/01/2015 ? 07/31/2017 NIH Biomarkers for Molecular-Based-Decision-Making in Diagnosis and Treatment of Interstitial Cystitis Co-Investigator R01 HL 114587 06/01/2013 ? 05/31/2018 NIH Genetic Risk for Granulomatous Interstitial Lung Disease PI of Subcontract R01 HL119962 07/01/2013 ? 06/30/2018 NHLBI The Role of Hepatocyte ABCA1 in Lipid Metabolism and Transport Co-Investigator UG1 VA189824 08/01/2014 ? 07/31/2019 NCI Wake Forest NCORP Research Base Co-Investigator R01 NS093870 02/01/2016 ? 01/31/2021 NIH Recurrence of Stroke in Minority Populations Co-Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. RILITE Foundation 12/01/2015 ? 11/30/2017 Informing Drug Repositioning and Development Through Genomics PI

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Jennifer Osborne, RN, BSN,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Ethnic/Racial Variations with Intracerebral Hemorrhage NIH-NS-069763 Genetic and Environmental Risk Factor for Hemorrhagic Stroke NIH-NS-036695

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bradford B. Worrall, MD, MSc,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology: Associate Editor 1 July 2009 - September 2015; Deputy Editor October 2015 - present Seminars in Neurology Editorial Board 2006-2014

    Patents:

    1. NONE

    Publishing Royalties:

    1. Chapter Author for Merritt's Neurology editions 10, 11, and 12.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS/NIH - R01 NS 069763 (co-investigator) 2010-2016 NINDS/NIH ? U-01 NS069208 (co-Prinicpal Investigator) 2010-2015 NHGRI/NIH ? U-01 HG005160 (co-Principal Investigator) 2009-2014

    Research Support, Academic Entities:

    1. University of Virginia - CENETERS OF EXCELLENCE CLINICAL RESEARCH GRANT SUPPORT - The UVA BRAIN AND AORTIC ANEURYSM SCREENING (BAAS) study - Principal Investigator 10/13-9/15

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Daniel Woo, MD, MS,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Stroke Research and Treatment, Associate Editor, 2010-2014.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH Funding: NS36695 (PI: 1998-Current); NS30678 (CoI: 1998-Current). NS69763 (PI: 2010-Current).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Sebastian Koch, MD;
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NINDS research support and salary support for site PI ofr 5 years U01-NS069763

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. For the ERICH Investigators
  1. From the Departments of Neurosurgery (C.-J.C.), Neurology (B.B.W.), and Public Health Sciences (B.B.W.), University of Virginia Health System, Charlottesville; Center for Public Health Genomics and Department of Biostatistical Sciences (W.M.B., C.D.L.), Wake Forest University School of Medicine, Winston-Salem, NC; Department of Neurology and Rehabilitation Medicine (C.J.M., J.O., D.W.), University of Cincinnati College of Medicine, OH; and Department of Neurology (S.K.), University of Miami Miller School of Medicine, FL. Coinvestigators are listed at Neurology.org.
  1. Correspondence to Dr. Koch: skoch{at}med.miami.edu
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