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January 24, 2017; 88 (4) Article

Dose-dependent progression of parkinsonism in manganese-exposed welders

Brad A. Racette, Susan Searles Nielsen, Susan R. Criswell, Lianne Sheppard, Noah Seixas, Mark N. Warden, Harvey Checkoway
First published December 28, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003533
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Article Information

vol. 88 no. 4 344-351
DOI: 
https://doi.org/10.1212/WNL.0000000000003533
PubMed: 
28031394
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received May 10, 2016
  • Accepted in final form September 12, 2016
  • First Published December 28, 2016.

Article Versions

Copyright & Usage: 
© 2016 American Academy of Neurology

Author Disclosures

    1. Brad A. Racette, MD,
    2. Susan Searles Nielsen, PhD,
    3. Susan R. Criswell, MD, MSCI,
    4. Lianne Sheppard, PhD,
    5. Noah Seixas, PhD,
    6. Mark N. Warden, MS and
    7. Harvey Checkoway, PhD
  1. Brad A. Racette, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. All the below are multi-center clinical trials: Teva Pharmaceuticals Adamas Pharmaceuticals Auspex Pharmaceuticals Eisai Allergan Pfizer Civitas Therapeutics

    Research Support, Government Entities:

    1. NIH R01ES025991 (PI-Racette) 7/1/2015 ? 6/30/2020 ?Motor and Cognitive Health Outcomes in a Mn-Exposed African Community? R01 ES021488-01A1 1/1/2013-12/31/2017 ?Imaging Biomarkers of Neurotoxicity in Welders? K24 NS060825 (PI-Racette) 4/1/2009 ? 6/30/19 ?Epidemiology and Biomarkers of Parkinsonism in Welders? 5R21ES17504 (PI- Racette) 7/01/2014 ? 6/30/2016 ?Risk of Parkinson Disease Associated with Solvent Exposures in Finland? R01ES021488-02S1 8/28/2014-8/27/2015 ?Imaging Biomarkers of Neurotoxicity in Welders?

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Michael J. Fox Foundation American Parkinson Disease Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Cassiday Schade, LLP- consultant Ogletree, Deakins, Nash, Smoak & Stewart, P.C.- consultant

  2. Susan Searles Nielsen, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) International Journal of Molecular Epidemiology and Genetics, Associate Board Member, 2012-present.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH-NIEHS, R01ES025991, Co-Investigator, 2015-present, (2) NIH-NIEHS, R01ES021488, Data Analyst, 2014-present, (3) NIH- NIEHS, R21ES024120, 2014-2016, (4) NIH-NIEHS, R01ES017462, Data Analyst, 2013-2015, (5) NIH-NIEHS, P42ES004696, Data Analyst, 2010-2014.

    Research Support, Academic Entities:

    1. (1) University of Washington

    Research Support, Foundations and Societies:

    1. (1) Michael J. Fox Foundation, (2) American Parkinson Disease Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Susan R. Criswell, MD, MSCI,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Analysis Group

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. The following are multi-center clinical trials: (1) Merck (PI) (2) Chiltern (Sub-I) (3) TEVA (Sub-I) (4) Medivation (PI)

    Research Support, Government Entities:

    1. NIH KL2 RR024994 Mentee 7/2008-6/2011 NIH R01 ES013743-01A2 Co-Investigator Racette (PI) ?Epidemiology of Parkinsonism in Welders?

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Parkinson Disease Association

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Lianne Sheppard, PhD,
    5. Scientific Advisory Boards:

    1. EPA Clean Air Scientific Advisory Committee Health Effects Institute Review Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Epidemiology, Editorial Board, 2010-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIEHS 1T32ES015459, Principal Investigator, 2009-present NIEHS 1R25ES025503, Principal investigator, 2015-present NIEHS 1R01ES021488, co-Investigator, 2012-present NIEHS R01ES025991, co-Investigator, 2015-present EPA RD-83479601, co-Investigator, 2010-present NIEHS K24ES013195, co-Investigator, 2009-2015 NIOSH R21OH010362, co-Investigator, 2013-2015 NIEHS 5P42ES004696, co-Investigator, 2009-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Noah Seixas, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. I am the chief editor of the Annals of Occupational Hygiene, and have been for the past 3 years.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. DEOHS, MAAF Pilot Research Grant. Work, Stress and Health among low wage workers in Seattle. 9/16-6/17. TC $49,982. CEEH Pilot Project (NIH Flow-through). Metabolomics signals for Mn exposure among welders. N. Seixas, PI, 2.5%., 6/14-5/15 TC $54,075. NIEHS, Subcontract to Washington University. Metabolomics of Mn Exposure Among Welders; Supplement to NIEHS Grant, Imaging Biomarkers of Neurotoxicity in Welders, B. Racette, PI. Subcontract PI, N. Seixas, 5% FTE. TC, $92,134. Washington Dept. of Labor & Industries, N Seixas, PI. 11/1/2014-10/31/2015 0.6 calendar Addressing the Health and Safety Needs of Washington Women in the Trades, TC $199,264

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Mark N. Warden, MS and
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Michael J. Fox Foundation, (2) American Parkinson Disease Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Harvey Checkoway, PhD
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. Research Methods in Occupational Epidemiology, 2nd ed. Oxford University Press, New York, NY, published 2004

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institute of Environmental Health Sciences, R01ES017462, role: PI, 2009-2016 National Institute of Environmental Health Sciences, R01ES021488, role: co-investigator, 2012-2017 National Institute of Environmental Health Sciences, R01ES025040, role: co-investigator, 2015-2020 National Institute of Environmental Health Sciences, R01ES025792, role: co-investigator, 2015-2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Multiple Sclerosis Society, RG4475A1, role: PI, 2013-2016

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (B.A.R., S.S.N., S.R.C., M.N.W.), Washington University School of Medicine, St. Louis, MO; School of Public Health, Faculty of Health Sciences (B.A.R.), University of the Witwatersrand, Johannesburg, South Africa; Department of Environmental and Occupational Health Sciences (L.S., N.S.), University of Washington, Seattle; and Department of Family Medicine and Public Health (H.C.), University of California, San Diego.
  1. Correspondence to Dr. Racette: racetteb{at}neuro.wustl.edu
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